Entity Details

Primary name WN10B_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO00744
EntryNameWN10B_HUMAN
FullNameProtein Wnt-10b
TaxID9606
Evidenceevidence at protein level
Length389
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesWNT10B

GO terms

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GOName
GO:0000086 G2/M transition of mitotic cell cycle
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0002062 chondrocyte differentiation
GO:0005109 frizzled binding
GO:0005125 cytokine activity
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0006629 lipid metabolic process
GO:0007224 smoothened signaling pathway
GO:0008284 positive regulation of cell population proliferation
GO:0010971 positive regulation of G2/M transition of mitotic cell cycle
GO:0014835 myoblast differentiation involved in skeletal muscle regeneration
GO:0016055 Wnt signaling pathway
GO:0030182 neuron differentiation
GO:0030501 positive regulation of bone mineralization
GO:0030858 positive regulation of epithelial cell differentiation
GO:0032434 regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0043065 positive regulation of apoptotic process
GO:0045165 cell fate commitment
GO:0045599 negative regulation of fat cell differentiation
GO:0045669 positive regulation of osteoblast differentiation
GO:0045899 positive regulation of RNA polymerase II transcription preinitiation complex assembly
GO:0048018 receptor ligand activity
GO:0048641 regulation of skeletal muscle tissue development
GO:0048741 skeletal muscle fiber development
GO:0050680 negative regulation of epithelial cell proliferation
GO:0050821 protein stabilization
GO:0050909 sensory perception of taste
GO:0051091 positive regulation of DNA-binding transcription factor activity
GO:0051885 positive regulation of timing of anagen
GO:0060070 canonical Wnt signaling pathway
GO:0060346 bone trabecula formation
GO:0061196 fungiform papilla development
GO:0071300 cellular response to retinoic acid
GO:0071320 cellular response to cAMP
GO:0071374 cellular response to parathyroid hormone stimulus
GO:0071425 hematopoietic stem cell proliferation
GO:0090263 positive regulation of canonical Wnt signaling pathway
GO:0120163 negative regulation of cold-induced thermogenesis

Subcellular Location

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Subcellular Location
Secreted

Domains

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DomainNameCategoryType
IPR005817 WntFamilyFamily
IPR013302 Wnt-10 proteinFamilyFamily
IPR018161 Wnt protein, conserved siteSiteConserved site
IPR043158 Wnt, C-terminal domainFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
225300 OMIMSplit-hand/foot malformation 6 (SHFM6)A limb malformation involving the central rays of the autopod and presenting with syndactyly, median clefts of the hands and feet, and aplasia and/or hypoplasia of the phalanges, metacarpals, and metatarsals. Some patients have been found to have mental retardation, ectodermal and craniofacial findings, and orofacial clefting. The disease is caused by variants affecting the gene represented in this entry.
617073 OMIMTooth agenesis, selective, 8 (STHAG8)A form of selective tooth agenesis, a common anomaly characterized by the congenital absence of one or more teeth. Selective tooth agenesis without associated systemic disorders has sometimes been divided into 2 types: oligodontia, defined as agenesis of 6 or more permanent teeth, and hypodontia, defined as agenesis of less than 6 teeth. The number in both cases does not include absence of third molars (wisdom teeth). STHAG8 inheritance is autosomal dominant. The disease is caused by variants affecting the gene represented in this entry. Potential genotype-phenotype correlation between variants and the positions of missing teeth.

Interactions

3 interactions