Entity Details

Primary name DYH5_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ8TE73
EntryNameDYH5_HUMAN
FullNameDynein axonemal heavy chain 5
TaxID9606
Evidenceevidence at protein level
Length4624
SequenceStatuscomplete
DateCreated2004-08-16
DateModified2021-06-02

Ontological Relatives

GenesDNAH5

GO terms

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GOName
GO:0003341 cilium movement
GO:0003351 epithelial cilium movement involved in extracellular fluid movement
GO:0005524 ATP binding
GO:0005576 extracellular region
GO:0005737 cytoplasm
GO:0005874 microtubule
GO:0005930 axoneme
GO:0007018 microtubule-based movement
GO:0007368 determination of left/right symmetry
GO:0007507 heart development
GO:0008569 minus-end-directed microtubule motor activity
GO:0021670 lateral ventricle development
GO:0030286 dynein complex
GO:0030317 flagellated sperm motility
GO:0031514 motile cilium
GO:0036157 outer dynein arm
GO:0036158 outer dynein arm assembly
GO:0045505 dynein intermediate chain binding
GO:0051649 establishment of localization in cell
GO:0051959 dynein light intermediate chain binding
GO:0060271 cilium assembly
GO:0097729 9+2 motile cilium

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR003593 AAA+ ATPase domainDomainDomain
IPR004273 Dynein heavy chain region D6 P-loop domainDomainDomain
IPR013594 Dynein heavy chain, tailDomainDomain
IPR013602 Dynein heavy chain, linkerDomainDomain
IPR024317 Dynein heavy chain, AAA module D4DomainDomain
IPR024743 Dynein heavy chain, coiled coil stalkDomainDomain
IPR026983 Dynein heavy chainFamilyFamily
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily
IPR035699 Dynein heavy chain, hydrolytic ATP-binding dynein motor regionDomainDomain
IPR035706 Dynein heavy chain, ATP-binding dynein motor regionDomainDomain
IPR041228 Dynein heavy chain, C-terminal domainDomainDomain
IPR041466 Dynein heavy chain, AAA 5 extension domainDomainDomain
IPR041589 Dynein heavy chain 3, AAA+ lid domainDomainDomain
IPR041658 Dynein heavy chain AAA lid domainDomainDomain
IPR042219 Dynein heavy chain AAA lid domain superfamilyFamilyHomologous superfamily
IPR042222 Dynein heavy chain, domain 2, N-terminalFamilyHomologous superfamily
IPR042228 Dynein heavy chain, linker, subdomain 3FamilyHomologous superfamily
IPR043157 Dynein heavy chain, AAA1 domain, small subdomainFamilyHomologous superfamily
IPR043160 Dynein heavy chain, C-terminal domain, barrel regionFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
608644 OMIMCiliary dyskinesia, primary, 3 (CILD3)A disorder characterized by abnormalities of motile cilia. Respiratory infections leading to chronic inflammation and bronchiectasis are recurrent, due to defects in the respiratory cilia; reduced fertility is often observed in male patients due to abnormalities of sperm tails. Half of the patients exhibit randomization of left-right body asymmetry and situs inversus, due to dysfunction of monocilia at the embryonic node. Primary ciliary dyskinesia associated with situs inversus is referred to as Kartagener syndrome. The disease is caused by variants affecting the gene represented in this entry.

Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
DYH5_HUMANIF4A2_HUMANIntAct17353931 details