Entity Details

Primary name LPIN2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ92539
EntryNameLPIN2_HUMAN
FullNamePhosphatidate phosphatase LPIN2
TaxID9606
Evidenceevidence at protein level
Length896
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesLPIN2

GO terms

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GOName
GO:0003713 transcription coactivator activity
GO:0005634 nucleus
GO:0005789 endoplasmic reticulum membrane
GO:0005829 cytosol
GO:0006629 lipid metabolic process
GO:0006646 phosphatidylethanolamine biosynthetic process
GO:0006656 phosphatidylcholine biosynthetic process
GO:0008195 phosphatidate phosphatase activity
GO:0009062 fatty acid catabolic process
GO:0019432 triglyceride biosynthetic process
GO:0032869 cellular response to insulin stimulus
GO:0044255 cellular lipid metabolic process
GO:0045944 positive regulation of transcription by RNA polymerase II

Subcellular Location

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Subcellular Location
Cytoplasm
Endoplasmic reticulum membrane
Nucleus

Domains

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DomainNameCategoryType
IPR007651 Lipin, N-terminalDomainDomain
IPR013209 Lipin/Ned1/Smp2 (LNS2)DomainDomain
IPR026058 LIPIN familyFamilyFamily
IPR031315 LNS2/PITPDomainDomain
IPR031703 Lipin, middle domainDomainDomain
IPR036412 HAD-like superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
609628 OMIMMajeed syndrome (MJDS)An autosomal recessive syndrome characterized by chronic recurrent multifocal osteomyelitis that is of early onset with a lifelong course, congenital dyserythropoietic anemia that presents as hypochromic, microcytic anemia during the first year of life and ranges from mild to transfusion-dependent, and transient inflammatory dermatosis, often manifesting as Sweet syndrome (neutrophilic skin infiltration). The disease is caused by variants affecting the gene represented in this entry.

Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
LPIN2_HUMANPP1A_HUMANBioGRID, IntAct22321011 details