Entity Details

Primary name SL9A6_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ92581
EntryNameSL9A6_HUMAN
FullNameSodium/hydrogen exchanger 6
TaxID9606
Evidenceevidence at protein level
Length669
SequenceStatuscomplete
DateCreated2000-05-30
DateModified2021-06-02

Ontological Relatives

GenesSLC9A6

GO terms

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GOName
GO:0005789 endoplasmic reticulum membrane
GO:0005886 plasma membrane
GO:0006811 ion transport
GO:0015385 sodium:proton antiporter activity
GO:0015386 potassium:proton antiporter activity
GO:0016021 integral component of membrane
GO:0031901 early endosome membrane
GO:0043231 intracellular membrane-bounded organelle
GO:0048675 axon extension
GO:0048812 neuron projection morphogenesis
GO:0051453 regulation of intracellular pH
GO:0055037 recycling endosome
GO:0055038 recycling endosome membrane
GO:0071805 potassium ion transmembrane transport
GO:0097484 dendrite extension
GO:0098719 sodium ion import across plasma membrane

Subcellular Location

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Subcellular Location
Endosome membrane
Recycling endosome membrane

Domains

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DomainNameCategoryType
IPR002090 Na+/H+ exchanger, isoform 6/7/9FamilyFamily
IPR004709 Na+/H+ exchangerFamilyFamily
IPR006153 Cation/H+ exchangerDomainDomain
IPR018422 Cation/H+ exchanger, CPA1 familyFamilyFamily

Diseases

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Disease IDSourceNameDescription
300243 OMIMMental retardation, X-linked, syndromic, Christianson type (MRXSCH)A syndrome characterized by profound mental retardation, epilepsy, ataxia, and microcephaly. It shows phenotypic overlap with Angelman syndrome. The disease is caused by variants affecting the gene represented in this entry.

Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
SL9A6_HUMANINGR1_HUMANBioGRID, IntAct28514442 32296183 details
SL9A6_HUMANCFTR_HUMANHPRD11707463 details