Entity Details

Primary name GHSR_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ92847
EntryNameGHSR_HUMAN
FullNameGrowth hormone secretagogue receptor type 1
TaxID9606
Evidenceevidence at protein level
Length366
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesGHSR

GO terms

Show/Hide Table
GOName
GO:0001616 growth hormone secretagogue receptor activity
GO:0004930 G protein-coupled receptor activity
GO:0005886 plasma membrane
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007283 spermatogenesis
GO:0007611 learning or memory
GO:0008154 actin polymerization or depolymerization
GO:0008343 adult feeding behavior
GO:0009725 response to hormone
GO:0009755 hormone-mediated signaling pathway
GO:0009986 cell surface
GO:0010700 negative regulation of norepinephrine secretion
GO:0016520 growth hormone-releasing hormone receptor activity
GO:0017046 peptide hormone binding
GO:0030252 growth hormone secretion
GO:0032094 response to food
GO:0032099 negative regulation of appetite
GO:0032100 positive regulation of appetite
GO:0032354 response to follicle-stimulating hormone
GO:0032355 response to estradiol
GO:0032691 negative regulation of interleukin-1 beta production
GO:0032715 negative regulation of interleukin-6 production
GO:0032720 negative regulation of tumor necrosis factor production
GO:0032869 cellular response to insulin stimulus
GO:0036321 ghrelin secretion
GO:0040018 positive regulation of multicellular organism growth
GO:0042802 identical protein binding
GO:0043005 neuron projection
GO:0043134 regulation of hindgut contraction
GO:0043568 positive regulation of insulin-like growth factor receptor signaling pathway
GO:0045121 membrane raft
GO:0045923 positive regulation of fatty acid metabolic process
GO:0046676 negative regulation of insulin secretion
GO:0046697 decidualization
GO:0050728 negative regulation of inflammatory response
GO:0051963 regulation of synapse assembly
GO:0051969 regulation of transmission of nerve impulse
GO:0060123 regulation of growth hormone secretion
GO:0060416 response to growth hormone
GO:0071222 cellular response to lipopolysaccharide
GO:0071548 response to dexamethasone
GO:0090327 negative regulation of locomotion involved in locomotory behavior
GO:0097067 cellular response to thyroid hormone stimulus
GO:0098685 Schaffer collateral - CA1 synapse
GO:0098696 regulation of neurotransmitter receptor localization to postsynaptic specialization membrane
GO:0098794 postsynapse
GO:0098978 glutamatergic synapse
GO:0099170 postsynaptic modulation of chemical synaptic transmission
GO:0099175 regulation of postsynapse organization
GO:0099699 integral component of synaptic membrane
GO:0120058 positive regulation of small intestinal transit
GO:1903672 positive regulation of sprouting angiogenesis
GO:1904000 positive regulation of eating behavior
GO:1904008 response to monosodium glutamate
GO:1904349 positive regulation of small intestine smooth muscle contraction
GO:1905333 regulation of gastric motility
GO:1905564 positive regulation of vascular endothelial cell proliferation
GO:1990314 cellular response to insulin-like growth factor stimulus
GO:2000110 negative regulation of macrophage apoptotic process

Subcellular Location

Show/Hide Table
Subcellular Location
Cell membrane

Domains

Show/Hide Table
DomainNameCategoryType
IPR000276 G protein-coupled receptor, rhodopsin-likeFamilyFamily
IPR003905 Growth hormone secretagogue receptor/motilin receptorFamilyFamily
IPR017452 GPCR, rhodopsin-like, 7TMDomainDomain
IPR039129 Growth hormone secretagogue receptorFamilyFamily

Diseases

Show/Hide Table
Disease IDSourceNameDescription
615925 OMIMGrowth hormone deficiency, isolated partial (GHDP)A disorder characterized by partial growth hormone deficiency resulting in growth delay and short stature, sometimes associated with recurrent episodes of abdominal pain, vomiting, ketosis and hypoglycemia. The disease is caused by variants affecting the gene represented in this entry.

Drugs

Show/Hide Table
DrugNameSourceType
DB12128 UlimorelinDrugbanksmall molecule
DB13074 MacimorelinDrugbanksmall molecule
DB15488 EchinacosideDrugbanksmall molecule