Entity Details
| Primary name |
PRG4_HUMAN |
| Entity type |
UniProt |
| Source |
Source Link |
Details
| Accession | Q92954 |
| EntryName | PRG4_HUMAN |
| FullName | Proteoglycan 4 |
| TaxID | 9606 |
| Evidence | evidence at protein level |
| Length | 1404 |
| SequenceStatus | complete |
| DateCreated | 2005-12-06 |
| DateModified | 2021-06-02 |
Subcellular Location
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| Subcellular Location |
| Secreted |
Domains
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| Domain | Name | Category | Type |
| IPR000585 | Hemopexin-like domain | Domain | Domain |
| IPR001212 | Somatomedin B domain | Domain | Domain |
| IPR018486 | Hemopexin, conserved site | Site | Conserved site |
| IPR018487 | Hemopexin-like repeats | Repeat | Repeat |
| IPR020436 | Somatomedin B, chordata | Domain | Domain |
| IPR036024 | Somatomedin B-like domain superfamily | Family | Homologous superfamily |
| IPR036375 | Hemopexin-like domain superfamily | Family | Homologous superfamily |
Diseases
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| Disease ID | Source | Name | Description |
| 208250 | OMIM | Camptodactyly-arthropathy-coxa vara-pericarditis syndrome (CACP) | An autosomal recessive disorder characterized by the association of congenital or early-onset camptodactyly and non-inflammatory arthropathy with synovial hyperplasia. Individuals with CACP have normal appearing joints at birth but with advancing age develop joint failure, non-inflammatory synoviocyte hyperplasia and subintimal fibrosis of the synovial capsule. Some patients also manifest progressive coxa vara deformity and/or non-inflammatory pericardial or pleural effusions. The disease is caused by variants affecting the gene represented in this entry. |
Interactions
1 interaction