Entity Details

Primary name AT2A3_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ93084
EntryNameAT2A3_HUMAN
FullNameSarcoplasmic/endoplasmic reticulum calcium ATPase 3
TaxID9606
Evidenceevidence at protein level
Length999
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesATP2A3

GO terms

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GOName
GO:0005388 P-type calcium transporter activity
GO:0005524 ATP binding
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0006816 calcium ion transport
GO:0006874 cellular calcium ion homeostasis
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0008553 P-type proton-exporting transporter activity
GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process
GO:0015085 calcium ion transmembrane transporter activity
GO:0016021 integral component of membrane
GO:0016529 sarcoplasmic reticulum
GO:0016887 ATP hydrolysis activity
GO:0030899 calcium-dependent ATPase activity
GO:0031090 organelle membrane
GO:0031095 platelet dense tubular network membrane
GO:0031965 nuclear membrane
GO:0033017 sarcoplasmic reticulum membrane
GO:0034220 ion transmembrane transport
GO:0044325 transmembrane transporter binding
GO:0046872 metal ion binding
GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0070588 calcium ion transmembrane transport
GO:0150104 transport across blood-brain barrier
GO:1900121 negative regulation of receptor binding
GO:1903515 calcium ion transport from cytosol to endoplasmic reticulum
GO:1903779 regulation of cardiac conduction

Subcellular Location

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Subcellular Location
Endoplasmic reticulum membrane
Nucleus membrane
Sarcoplasmic reticulum membrane

Domains

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DomainNameCategoryType
IPR001757 P-type ATPaseFamilyFamily
IPR004014 Cation-transporting P-type ATPase, N-terminalDomainDomain
IPR005782 P-type ATPase, subfamily IIA, SERCA-typeFamilyFamily
IPR006068 Cation-transporting P-type ATPase, C-terminalDomainDomain
IPR008250 P-type ATPase, A domain superfamilyFamilyHomologous superfamily
IPR018303 P-type ATPase, phosphorylation sitePTMPTM
IPR023214 HAD superfamilyFamilyHomologous superfamily
IPR023298 P-type ATPase, transmembrane domain superfamilyFamilyHomologous superfamily
IPR023299 P-type ATPase, cytoplasmic domain NFamilyHomologous superfamily
IPR036412 HAD-like superfamilyFamilyHomologous superfamily
IPR044492 P-type ATPase, haloacid dehalogenase domainDomainDomain

Diseases

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