Entity Details

Primary name CR3L1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ96BA8
EntryNameCR3L1_HUMAN
FullNameCyclic AMP-responsive element-binding protein 3-like protein 1
TaxID9606
Evidenceevidence at protein level
Length519
SequenceStatuscomplete
DateCreated2007-05-29
DateModified2021-06-02

Ontological Relatives

GenesCREB3L1

GO terms

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GOName
GO:0000785 chromatin
GO:0000976 transcription cis-regulatory region binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0001649 osteoblast differentiation
GO:0003682 chromatin binding
GO:0005634 nucleus
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0006357 regulation of transcription by RNA polymerase II
GO:0007275 multicellular organism development
GO:0010629 negative regulation of gene expression
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016032 viral process
GO:0030968 endoplasmic reticulum unfolded protein response
GO:0032967 positive regulation of collagen biosynthetic process
GO:0035497 cAMP response element binding
GO:0040037 negative regulation of fibroblast growth factor receptor signaling pathway
GO:0045892 negative regulation of transcription, DNA-templated
GO:0046332 SMAD binding
GO:0070278 extracellular matrix constituent secretion
GO:1902236 negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
GO:1903671 negative regulation of sprouting angiogenesis
GO:1990440 positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
GO:1990837 sequence-specific double-stranded DNA binding

Subcellular Location

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Subcellular Location
Endoplasmic reticulum membrane
Nucleus

Domains

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DomainNameCategoryType
IPR004827 Basic-leucine zipper domainDomainDomain
IPR029805 cAMP-responsive element-binding protein 3-like protein 1FamilyFamily

Diseases

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Disease IDSourceNameDescription
616229 OMIMOsteogenesis imperfecta 16 (OI16)An autosomal recessive form of osteogenesis imperfecta, a connective tissue disorder characterized by low bone mass, bone fragility and susceptibility to fractures after minimal trauma. Disease severity ranges from very mild forms without fractures to intrauterine fractures and perinatal lethality. Extraskeletal manifestations, which affect a variable number of patients, are dentinogenesis imperfecta, hearing loss, and blue sclerae. OI16 is a severe form. The disease may be caused by variants affecting the gene represented in this entry. OI16 affected patients show a genomic deletion encompassing CREB3L1 and the first exon of DGKZ. The absence of this exon does not affect all DGKZ isoforms, some are still produced at normal level. It cannot be ruled out that DGKZ could contribute to the phenotype, but in view of its role in bone formation, CREB3L1 is a strong OI16-causing candidate (PubMed:24079343). This hypothesis is corroborated by the observation of CREB3L1 knockout mice which exhibit features reminiscent of severe human osteogenesis imperfecta.

Interactions

199 interactions

InteractorPartnerSourcesPublicationsLink
CR3L1_HUMANCR3L1_HUMANBioGRID, HPRD, MINT, UniProt12805554 23661758 details
CR3L1_HUMANFXYD3_HUMANBioGRID, IntAct, MINT21516116 32296183 details
CR3L1_HUMANTMM11_HUMANBioGRID, IntAct, MINT21516116 32296183 details
CR3L1_HUMANTM218_HUMANBioGRID, IntAct25416956 29892012 32296183 details
CR3L1_HUMANGPR25_HUMANBioGRID, IntAct25416956 31515488 32296183 details
CR3L1_HUMANAAKB2_HUMANBioGRID, IntAct24722188 25416956 details
CR3L1_HUMANCO5_HUMANBioGRID, IntAct25416956 details
CR3L1_HUMANTSPO_HUMANBioGRID, IntAct25416956 31515488 32296183 details
CR3L1_HUMANMTG8_HUMANBioGRID, IntAct25416956 details
CR3L1_HUMANMFSD5_HUMANBioGRID, IntAct21516116 25416956 32296183 details
CR3L1_HUMANZNT8_HUMANBioGRID, IntAct25416956 25910212 32296183 details
CR3L1_HUMANNRM_HUMANBioGRID, IntAct25416956 details
CR3L1_HUMANJAGN1_HUMANBioGRID, IntAct25416956 details
CR3L1_HUMANTM234_HUMANBioGRID, IntAct25416956 details
CR3L1_HUMANFAM3C_HUMANBioGRID, IntAct25416956 31515488 details
CR3L1_HUMANS35B4_HUMANBioGRID, IntAct25416956 32296183 details
CR3L1_HUMANTM147_HUMANBioGRID, IntAct25416956 31515488 32296183 details
CR3L1_HUMANFXYD6_HUMANBioGRID, IntAct25416956 32296183 details
CR3L1_HUMANPGAP2_HUMANBioGRID, IntAct26871637 32296183 details
CR3L1_HUMANMYPR_HUMANBioGRID, IntAct25910212 26871637 32296183 details
CR3L1_HUMANPLPP6_HUMANBioGRID, IntAct32296183 details
CR3L1_HUMANLPAR3_HUMANBioGRID, IntAct32296183 details
CR3L1_HUMANAOC3_HUMANBioGRID, IntAct32296183 details
CR3L1_HUMANVAMP1_HUMANBioGRID, IntAct32296183 details
CR3L1_HUMANM4A13_HUMANBioGRID, IntAct32296183 details
CR3L1_HUMANRNS10_HUMANBioGRID, IntAct32296183 details
CR3L1_HUMANKCNK1_HUMANBioGRID, IntAct32296183 details
CR3L1_HUMANPMP22_HUMANBioGRID, IntAct32296183 details
CR3L1_HUMANBI1_HUMANBioGRID, IntAct32296183 details
CR3L1_HUMANCNIH2_HUMANBioGRID, IntAct32296183 details
CR3L1_HUMANTM14C_HUMANBioGRID, IntAct32296183 details
CR3L1_HUMANGIMA5_HUMANBioGRID, IntAct32296183 details
CR3L1_HUMANVKOR1_HUMANBioGRID, IntAct32296183 details
CR3L1_HUMANT229B_HUMANBioGRID, IntAct32296183 details
CR3L1_HUMANMAL_HUMANBioGRID, IntAct32296183 details
CR3L1_HUMANPLCE_HUMANBioGRID, IntAct32296183 details
CR3L1_HUMANSTX3_HUMANBioGRID, IntAct32296183 details
CR3L1_HUMANSAC1_HUMANBioGRID, IntAct32296183 details
CR3L1_HUMANTIM23_HUMANBioGRID, IntAct32296183 details
CR3L1_HUMANTECR_HUMANBioGRID, IntAct32296183 details
CR3L1_HUMANGOT1B_HUMANBioGRID, IntAct32296183 details
CR3L1_HUMANCKLF7_HUMANBioGRID, IntAct32296183 details
CR3L1_HUMANSC61G_HUMANBioGRID, IntAct32296183 details
CR3L1_HUMANBNIP3_HUMANBioGRID, IntAct32296183 details
CR3L1_HUMANCKLF3_HUMANBioGRID, IntAct32296183 details
CR3L1_HUMANSMCO4_HUMANBioGRID, IntAct32296183 details
CR3L1_HUMANCOMT_HUMANBioGRID, IntAct32296183 details
CR3L1_HUMANSMIM1_HUMANBioGRID, IntAct32296183 details
CR3L1_HUMANSEM4G_HUMANBioGRID, IntAct32296183 details
CR3L1_HUMANFA2H_HUMANBioGRID, IntAct32296183 details
CR3L1_HUMANCTXN3_HUMANBioGRID, IntAct32296183 details
CR3L1_HUMANPLCC_HUMANBioGRID, IntAct32296183 details
CR3L1_HUMANTM14A_HUMANBioGRID, IntAct32296183 details
CR3L1_HUMANVAMP2_HUMANBioGRID, IntAct32296183 details
CR3L1_HUMANAPOD_HUMANBioGRID, IntAct32296183 details
CR3L1_HUMANCIA2A_HUMANBioGRID, IntAct32296183 details
CR3L1_HUMANCD20_HUMANBioGRID, IntAct32296183 details
CR3L1_HUMANENTP3_HUMANBioGRID, IntAct32296183 details
CR3L1_HUMANSTX8_HUMANBioGRID, IntAct32296183 details
CR3L1_HUMANPLPR2_HUMANBioGRID, IntAct32296183 details
CR3L1_HUMANTM86A_HUMANBioGRID, IntAct32296183 details
CR3L1_HUMANCD72_HUMANBioGRID, IntAct32296183 details
CR3L1_HUMANPLP2_HUMANBioGRID, IntAct32296183 details
CR3L1_HUMANPTN9_HUMANBioGRID, IntAct32296183 details
CR3L1_HUMANRUSF1_HUMANBioGRID, IntAct32296183 details
CR3L1_HUMANARV1_HUMANBioGRID, IntAct32296183 details
CR3L1_HUMANLERL1_HUMANBioGRID, IntAct32296183 details
CR3L1_HUMANNINJ2_HUMANBioGRID, IntAct32296183 details
CR3L1_HUMANGTR3_HUMANBioGRID, IntAct32296183 details
CR3L1_HUMANS35B1_HUMANBioGRID, IntAct32296183 details
CR3L1_HUMANALG8_HUMANBioGRID, IntAct32296183 details
CR3L1_HUMANPEX16_HUMANBioGRID, IntAct32296183 details
CR3L1_HUMANEBP_HUMANBioGRID, IntAct32296183 details
CR3L1_HUMANLHPL5_HUMANBioGRID, IntAct32296183 details
CR3L1_HUMANTM14B_HUMANBioGRID, IntAct32296183 details
CR3L1_HUMANS52A1_HUMANBioGRID, IntAct32296183 details
CR3L1_HUMANINSI2_HUMANBioGRID, IntAct32296183 details
CR3L1_HUMANPLCD_HUMANBioGRID, IntAct32296183 details
CR3L1_HUMANTM239_HUMANBioGRID, IntAct32296183 details
CR3L1_HUMANSNAB_HUMANBioGRID, IntAct32296183 details
CR3L1_HUMANOLFM4_HUMANBioGRID, IntAct32296183 details
CR3L1_HUMANMA2B2_HUMANBioGRID, IntAct32296183 details
CR3L1_HUMANANR46_HUMANBioGRID, IntAct32296183 details
CR3L1_HUMANORML1_HUMANBioGRID, IntAct32296183 details
CR3L1_HUMANS35A4_HUMANBioGRID, IntAct32296183 details
CR3L1_HUMANMGA_HUMANBioGRID, IntAct32296183 details
CR3L1_HUMANSL7A1_HUMANBioGRID, IntAct32296183 details
CR3L1_HUMANZDH15_HUMANBioGRID, IntAct32296183 details
CR3L1_HUMANZFPL1_HUMANBioGRID, IntAct32296183 details
CR3L1_HUMANPAQRA_HUMANBioGRID, IntAct32296183 details
CR3L1_HUMANS35B2_HUMANBioGRID, IntAct32296183 details
CR3L1_HUMANILRL1_HUMANBioGRID, IntAct32296183 details
CR3L1_HUMANCP4F2_HUMANBioGRID, IntAct32296183 details
CR3L1_HUMANZDH22_HUMANBioGRID, IntAct32296183 details
CR3L1_HUMANGOSR2_HUMANBioGRID, IntAct32296183 details
CR3L1_HUMANEMP3_HUMANBioGRID, IntAct32296183 details
CR3L1_HUMANCD53_HUMANBioGRID, IntAct32296183 details
CR3L1_HUMANSFXN5_HUMANBioGRID, IntAct32296183 details
CR3L1_HUMANS13A2_HUMANBioGRID, IntAct32296183 details
CR3L1_HUMANPAQR6_HUMANBioGRID, IntAct32296183 details
CR3L1_HUMANCOX20_HUMANBioGRID, IntAct32296183 details
CR3L1_HUMANRFT1_HUMANBioGRID, IntAct32296183 details
CR3L1_HUMANNINJ1_HUMANBioGRID, IntAct32296183 details
CR3L1_HUMANLTC4S_HUMANBioGRID, IntAct32296183 details
CR3L1_HUMANUN93B_HUMANBioGRID, IntAct32296183 details
CR3L1_HUMANYIPF6_HUMANBioGRID, IntAct32296183 details
CR3L1_HUMANTMM19_HUMANBioGRID, IntAct32296183 details
CR3L1_HUMANORML2_HUMANBioGRID, IntAct32296183 details
CR3L1_HUMANFXDC2_HUMANBioGRID, IntAct32296183 details
CR3L1_HUMANMOT13_HUMANBioGRID, IntAct32296183 details
CR3L1_HUMANMALL_HUMANBioGRID, IntAct32296183 details
CR3L1_HUMANS39A2_HUMANBioGRID, IntAct32296183 details
CR3L1_HUMANNEUR1_HUMANBioGRID, IntAct32296183 details
CR3L1_HUMANTSPO2_HUMANBioGRID, IntAct32296183 details
CR3L1_HUMANTNFA_HUMANBioGRID, IntAct32296183 details
CR3L1_HUMANNAT8_HUMANBioGRID, IntAct32296183 details
CR3L1_HUMANAQP2_HUMANBioGRID, IntAct32296183 details
CR3L1_HUMANMAL2_HUMANBioGRID, IntAct32296183 details
CR3L1_HUMANDOLK_HUMANBioGRID, IntAct32296183 details
CR3L1_HUMANSG1D1_HUMANBioGRID, IntAct32296183 details
CR3L1_HUMANSNG1_HUMANBioGRID, IntAct32296183 details
CR3L1_HUMANBMP10_HUMANBioGRID, IntAct32296183 details
CR3L1_HUMANITAM_HUMANBioGRID, IntAct32296183 details
CR3L1_HUMANCLN6_HUMANBioGRID, IntAct32296183 details
CR3L1_HUMANFETUB_HUMANBioGRID, IntAct32296183 details
CR3L1_HUMANERMP1_HUMANBioGRID, IntAct32296183 details
CR3L1_HUMANGP151_HUMANBioGRID, IntAct32296183 details
CR3L1_HUMANTNMD_HUMANBioGRID, IntAct32296183 details
CR3L1_HUMANTIDC1_HUMANBioGRID, IntAct32296183 details
CR3L1_HUMANCK024_HUMANBioGRID, IntAct32296183 details
CR3L1_HUMANTFR1_HUMANBioGRID, IntAct32296183 details
CR3L1_HUMANAQP10_HUMANBioGRID, IntAct32296183 details
CR3L1_HUMANTM50B_HUMANBioGRID, IntAct32296183 details
CR3L1_HUMANADIPO_HUMANBioGRID, IntAct32296183 details
CR3L1_HUMANMARH2_HUMANBioGRID, IntAct32296183 details
CR3L1_HUMANMGST3_HUMANBioGRID, IntAct32296183 details
CR3L1_HUMANSTX7_HUMANBioGRID, IntAct32296183 details
CR3L1_HUMANPLPP4_HUMANBioGRID, IntAct32296183 details
CR3L1_HUMANGAST_HUMANBioGRID, IntAct32296183 details
CR3L1_HUMANTM203_HUMANBioGRID, IntAct32296183 details
CR3L1_HUMANERG28_HUMANBioGRID, IntAct32296183 details
CR3L1_HUMANBRID5_HUMANBioGRID, IntAct32296183 details
CR3L1_HUMANTSN2_HUMANBioGRID, IntAct32296183 details
CR3L1_HUMANBET1_HUMANBioGRID, IntAct32296183 details
CR3L1_HUMANFHR5_HUMANBioGRID, IntAct25910212 32296183 details
CR3L1_HUMANMGST2_HUMANBioGRID, IntAct32296183 details
CR3L1_HUMANT120B_HUMANBioGRID, IntAct32296183 details
CR3L1_HUMANTLCD1_HUMANBioGRID, IntAct32296183 details
CR3L1_HUMANTM222_HUMANBioGRID, IntAct32296183 details
CR3L1_HUMANSC22A_HUMANBioGRID, IntAct32296183 details
CR3L1_HUMANGIMA1_HUMANBioGRID, IntAct32296183 details
CR3L1_HUMANCD003_HUMANBioGRID, IntAct32296183 details
CR3L1_HUMANTR10C_HUMANBioGRID, IntAct32296183 details
CR3L1_HUMANNSG1_HUMANBioGRID, IntAct32296183 details
CR3L1_HUMANS13A3_HUMANBioGRID, IntAct32296183 details
CR3L1_HUMANSREC_HUMANBioGRID, IntAct32296183 details
CR3L1_HUMANTX264_HUMANBioGRID, IntAct32296183 details
CR3L1_HUMANO10AG_HUMANBioGRID, IntAct32296183 details
CR3L1_HUMANS39A9_HUMANBioGRID, IntAct32296183 details
CR3L1_HUMANRHBL4_HUMANBioGRID, IntAct32296183 details
CR3L1_HUMANSC22B_HUMANBioGRID, IntAct32296183 details
CR3L1_HUMANCC4L_HUMANBioGRID, IntAct32296183 details
CR3L1_HUMANAGRE2_HUMANBioGRID, IntAct32296183 details
CR3L1_HUMANASGR1_HUMANBioGRID, IntAct32296183 details
CR3L1_HUMANSYJ2B_HUMANBioGRID, IntAct32296183 details
CR3L1_HUMANG37L1_HUMANBioGRID, IntAct32296183 details
CR3L1_HUMANCGAT2_HUMANBioGRID, IntAct32296183 details
CR3L1_HUMANTR1L1_HUMANBioGRID, IntAct32296183 details
CR3L1_HUMANERG1_HUMANBioGRID, IntAct32296183 details
CR3L1_HUMANS35C2_HUMANBioGRID, IntAct32296183 details
CR3L1_HUMANTICN1_HUMANBioGRID, IntAct32296183 details
CR3L1_HUMANRHD_HUMANBioGRID, IntAct32296183 details
CR3L1_HUMANWFDC2_HUMANBioGRID, IntAct32296183 details
CR3L1_HUMANC56D2_HUMANBioGRID, IntAct32296183 details
CR3L1_HUMANTM208_HUMANBioGRID, IntAct32296183 details
CR3L1_HUMANUBIA1_HUMANBioGRID, IntAct32296183 details
CR3L1_HUMANHACD2_HUMANBioGRID, IntAct32296183 details
CR3L1_HUMANSCD_HUMANBioGRID, IntAct32296183 details
CR3L1_HUMANPPLA_HUMANBioGRID, IntAct25910212 details
CR3L1_HUMANCR3L3_HUMANBioGRID, HPRD, UniProt12805554 23661758 details
CR3L1_HUMANDDIT3_HUMANBioGRID, UniProt23661758 details
CR3L1_HUMANCREB3_HUMANBioGRID23661758 details
CR3L1_HUMANTSPOB_HUMANBioGRID25416956 32296183 details
CR3L1_HUMANPGRC1_HUMANBioGRID25416956 details
CR3L1_HUMANCYBC1_HUMANBioGRID21516116 details
CR3L1_HUMANTM128_HUMANBioGRID21516116 details
CR3L1_HUMANHIF1A_HUMANBioGRID26558437 details
CR3L1_HUMANC99L2_HUMANBioGRID26871637 details
CR3L1_HUMANVEZA_HUMANBioGRID32296183 details
CR3L1_HUMANPPGB_HUMANBioGRID32296183 details
CR3L1_HUMANPDES1_HUMANBioGRID32296183 details
CR3L1_HUMANUB2V1_HUMANBioGRID32296183 details
CR3L1_HUMANADA33_HUMANBioGRID32296183 details
CR3L1_HUMANCXL16_HUMANBioGRID32296183 details
CR3L1_HUMANCO8A2_HUMANBioGRID32296183 details
CR3L1_HUMANS35U4_HUMANBioGRID32296183 details
CR3L1_HUMANTMIE_HUMANBioGRID32296183 details
CR3L1_HUMANEPAS1_HUMANBioGRID26558437 details
CR3L1_HUMANCREM_HUMANHPRD12805554 details