Entity Details

Primary name MP2K7_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO14733
EntryNameMP2K7_HUMAN
FullNameDual specificity mitogen-activated protein kinase kinase 7
TaxID9606
Evidenceevidence at protein level
Length419
SequenceStatuscomplete
DateCreated2000-05-30
DateModified2021-06-02

Ontological Relatives

GenesMAP2K7

GO terms

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GOName
GO:0000187 obsolete activation of MAPK activity
GO:0000287 magnesium ion binding
GO:0004708 MAP kinase kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006915 apoptotic process
GO:0006970 response to osmotic stress
GO:0007165 signal transduction
GO:0007254 JNK cascade
GO:0007257 obsolete activation of JUN kinase activity
GO:0008545 JUN kinase kinase activity
GO:0009408 response to heat
GO:0009411 response to UV
GO:0019899 enzyme binding
GO:0019901 protein kinase binding
GO:0019903 protein phosphatase binding
GO:0032212 positive regulation of telomere maintenance via telomerase
GO:0034612 response to tumor necrosis factor
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0045893 positive regulation of transcription, DNA-templated
GO:0051403 stress-activated MAPK cascade
GO:0051973 positive regulation of telomerase activity
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:1904355 positive regulation of telomere capping

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

44 interactions

InteractorPartnerSourcesPublicationsLink
MP2K7_HUMANARRC_HUMANHPRD, IntAct16169070 details
MP2K7_HUMANMK08_HUMANBioGRID, HPRD, IntAct10713157 11062067 12821118 13130464 16533805 24975362 25241761 25284480 26364603 9207092 details
MP2K7_HUMANM3K1_HUMANBioGRID, MINT14500727 15866172 17110930 details
MP2K7_HUMANJIP1_HUMANBioGRID, HPRD, IntAct, MINT10490659 16456539 16840345 18286207 details
MP2K7_HUMANATF4_HUMANBioGRID, IntAct21988832 details
MP2K7_HUMANRL30_HUMANBioGRID, IntAct21988832 details
MP2K7_HUMANLPXN_HUMANBioGRID, IntAct21988832 details
MP2K7_HUMANLRRK2_HUMANBioGRID, IntAct19302196 20067578 details
MP2K7_HUMANGA45B_HUMANBioGRID, HPRD, IntAct14743220 25314077 details
MP2K7_HUMANJIP2_HUMANBioGRID, HPRD10490659 10756100 details
MP2K7_HUMANDUS19_HUMANBioGRID, HPRD11959861 11959862 details
MP2K7_HUMANJIP3_HUMANBioGRID, HPRD10629060 12189133 32427938 details
MP2K7_HUMANM3K11_HUMANBioGRID, HPRD10187804 15001580 details
MP2K7_HUMANM3K12_HUMANBioGRID, HPRD10187804 details
MP2K7_HUMANM3K13_HUMANBioGRID11726277 details
MP2K7_HUMANMK14_HUMANBioGRID9207092 details
MP2K7_HUMANM3K2_HUMANBioGRID, HPRD10713157 24975362 9372971 details
MP2K7_HUMANM3K4_HUMANBioGRID15866172 details
MP2K7_HUMANMK09_HUMANBioGRID, HPRD11062067 12821118 16533805 details
MP2K7_HUMANMK01_HUMANBioGRID15192046 16533805 7499408 details
MP2K7_HUMANJUN_HUMANBioGRID13130464 details
MP2K7_HUMANM3K3_HUMANBioGRID24975362 details
MP2K7_HUMANBRAF_HUMANBioGRID27034005 30082909 details
MP2K7_HUMANRBP2_HUMANBioGRID26364603 details
MP2K7_HUMANTAU_HUMANBioGRID9614189 details
MP2K7_HUMANTRIB3_HUMANIntAct15299019 details
MP2K7_HUMANCFLAR_HUMANHPRD, MINT17110930 details
MP2K7_HUMANM3K5_HUMANBioGRID, HPRD, MINT11959862 17110930 details
MP2K7_HUMANM3K7_HUMANBioGRID, IntAct, MINT17110930 17709393 25241761 details
MP2K7_HUMANVRK2_HUMANBioGRID, HPRD, IntAct18286207 details
MP2K7_HUMANHS90B_HUMANIntAct22939624 details
MP2K7_HUMANM3K20_HUMANBioGRID, HPRD11836244 15465036 details
MP2K7_HUMANALK_HUMANBioGRID14968112 details
MP2K7_HUMANMP2K4_HUMANBioGRID13130464 details
MP2K7_HUMANWDR6_HUMANBioGRID19910486 details
MP2K7_HUMANBCL10_HUMANBioGRID17189706 details
MP2K7_HUMANHS90A_HUMANBioGRID22939624 details
MP2K7_HUMANRASN_HUMANBioGRID7499408 details
MP2K7_HUMANSH3R3_HUMANBioGRID32427938 details
MP2K7_HUMANMP2K7_HUMANHPRD10629060 12189133 15465036 details
MP2K7_HUMANTRIB1_HUMANHPRD15299019 details
MP2K7_HUMANDUS22_HUMANHPRD12138158 details
MP2K7_HUMANCNKR1_HUMANHPRD15753034 details
MP2K7_HUMANTRAF6_HUMANHPRD16313339 details