Entity Details

Primary name NHRF1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO14745
EntryNameNHRF1_HUMAN
FullNameNa(+)/H(+) exchange regulatory cofactor NHE-RF1
TaxID9606
Evidenceevidence at protein level
Length358
SequenceStatuscomplete
DateCreated2004-02-02
DateModified2021-06-02

Ontological Relatives

GenesSLC9A3R1

GO terms

Show/Hide Table
GOName
GO:0001726 ruffle
GO:0002009 morphogenesis of an epithelium
GO:0003096 renal sodium ion transport
GO:0005102 signaling receptor binding
GO:0005737 cytoplasm
GO:0005902 microvillus
GO:0007009 plasma membrane organization
GO:0007097 nuclear migration
GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway
GO:0007605 sensory perception of sound
GO:0008013 beta-catenin binding
GO:0008285 negative regulation of cell population proliferation
GO:0008360 regulation of cell shape
GO:0008361 regulation of cell size
GO:0010642 negative regulation of platelet-derived growth factor receptor signaling pathway
GO:0012505 endomembrane system
GO:0014067 negative regulation of phosphatidylinositol 3-kinase signaling
GO:0015185 gamma-aminobutyric acid transmembrane transporter activity
GO:0015629 actin cytoskeleton
GO:0016020 membrane
GO:0016055 Wnt signaling pathway
GO:0016324 apical plasma membrane
GO:0017081 chloride channel regulator activity
GO:0019902 phosphatase binding
GO:0019933 cAMP-mediated signaling
GO:0022612 gland morphogenesis
GO:0030033 microvillus assembly
GO:0030036 actin cytoskeleton organization
GO:0030165 PDZ domain binding
GO:0030175 filopodium
GO:0030336 negative regulation of cell migration
GO:0030643 cellular phosphate ion homeostasis
GO:0031526 brush border membrane
GO:0031528 microvillus membrane
GO:0031698 beta-2 adrenergic receptor binding
GO:0031799 type 2 metabotropic glutamate receptor binding
GO:0031800 type 3 metabotropic glutamate receptor binding
GO:0031982 vesicle
GO:0032415 regulation of sodium:proton antiporter activity
GO:0032416 negative regulation of sodium:proton antiporter activity
GO:0032426 stereocilium tip
GO:0032782 bile acid secretion
GO:0034635 glutathione transport
GO:0034767 positive regulation of ion transmembrane transport
GO:0043495 protein-membrane adaptor activity
GO:0043621 protein self-association
GO:0044062 regulation of excretion
GO:0044782 cilium organization
GO:0044877 protein-containing complex binding
GO:0045121 membrane raft
GO:0045159 myosin II binding
GO:0045198 establishment of epithelial cell apical/basal polarity
GO:0045199 maintenance of epithelial cell apical/basal polarity
GO:0045859 regulation of protein kinase activity
GO:0045930 negative regulation of mitotic cell cycle
GO:0047485 protein N-terminus binding
GO:0048471 perinuclear region of cytoplasm
GO:0050780 dopamine receptor binding
GO:0051683 establishment of Golgi localization
GO:0051898 negative regulation of protein kinase B signaling
GO:0051939 gamma-aminobutyric acid import
GO:0060088 auditory receptor cell stereocilium organization
GO:0060158 phospholipase C-activating dopamine receptor signaling pathway
GO:0065003 protein-containing complex assembly
GO:0070062 extracellular exosome
GO:0070293 renal absorption
GO:0070373 negative regulation of ERK1 and ERK2 cascade
GO:0070851 growth factor receptor binding
GO:0071944 cell periphery
GO:0072659 protein localization to plasma membrane
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0090660 cerebrospinal fluid circulation
GO:0097225 sperm midpiece
GO:0097291 renal phosphate ion absorption
GO:0098739 import across plasma membrane
GO:0098797 plasma membrane protein complex
GO:0150104 transport across blood-brain barrier
GO:2001244 positive regulation of intrinsic apoptotic signaling pathway

Subcellular Location

Show/Hide Table
Subcellular Location
Apical cell membrane
Cell projection
Cytoplasm
Endomembrane system

Domains

Show/Hide Table
DomainNameCategoryType
IPR001478 PDZ domainDomainDomain
IPR015098 EBP50, C-terminalDomainDomain
IPR017300 Na(+)/H(+) exchange regulatory cofactor NHERF-1/2FamilyFamily
IPR031199 Na(+)/H(+) exchange regulatory cofactor NHERF-1FamilyFamily
IPR036034 PDZ superfamilyFamilyHomologous superfamily
IPR041489 PDZ domain 6DomainDomain

Diseases

Show/Hide Table
Disease IDSourceNameDescription
612287 OMIMNephrolithiasis/osteoporosis, hypophosphatemic, 2 (NPHLOP2)A disease characterized by decreased renal phosphate absorption, renal phosphate wasting, hypophosphatemia, hyperphosphaturia, hypercalciuria, nephrolithiasis and osteoporosis. The disease is caused by variants affecting the gene represented in this entry.

Interactions

79 interactions

InteractorPartnerSourcesPublicationsLink
NHRF1_HUMANPHAG1_HUMANBioGRID, HPRD, MINT11684085 details
NHRF1_HUMANCLCN3_HUMANBioGRID, HPRD, IntAct11967229 12471024 details
NHRF1_HUMANCFTR_HUMANBioGRID, DIP, HPRD, IntAct, MINT10852925 11158634 12403779 12471024 12615054 15553237 17110338 17244609 19446522 26618866 28360110 9613608 9671706 9677412 details
NHRF1_HUMANMOES_HUMANBioGRID, HPRD, IntAct15020681 9430655 details
NHRF1_HUMANEZRI_HUMANBioGRID, HPRD, IntAct, MINT11285285 11684085 15020681 20937695 23414517 26344197 29568061 34079125 9314537 details
NHRF1_HUMANOPRK_HUMANBioGRID, HPRD, MINT12004055 15070904 details
NHRF1_HUMANYAP1_HUMANBioGRID, HPRD, MINT10562288 details
NHRF1_HUMANYES_HUMANBioGRID, MINT10562288 details
NHRF1_HUMANTB10A_HUMANBioGRID, HPRD, IntAct, MINT11285285 20937695 details
NHRF1_HUMANRHG17_HUMANMINT11285285 details
NHRF1_HUMANADRB2_HUMANBioGRID, HPRD, MINT11526121 11882663 9560162 9671706 details
NHRF1_HUMANP2RY2_HUMANMINT9671706 details
NHRF1_HUMANP2RY1_HUMANBioGRID, HPRD, MINT9671706 details
NHRF1_HUMANPTEN_HUMANBioGRID, HPRD, MINT, UniProt16456542 21804599 21990315 23118026 24012959 26531778 30631154 details
NHRF1_HUMANPGFRB_HUMANBioGRID, HPRD, IntAct, MINT11046132 16456542 23397142 24012959 details
NHRF1_HUMANMERL_HUMANBioGRID, HPRD, IntAct15467741 26045165 9430655 details
NHRF1_HUMANPHLP2_HUMANBioGRID, IntAct, UniProt19615732 21804599 27880917 details
NHRF1_HUMANFZD4_HUMANI2D20802536 details
NHRF1_HUMANBCL10_HUMANBioGRID, IntAct21988832 details
NHRF1_HUMANZN468_HUMANBioGRID, IntAct21988832 details
NHRF1_HUMANPHLP1_HUMANBioGRID, UniProt21804599 details
NHRF1_HUMANB2LA1_HUMANBioGRID, IntAct27107012 details
NHRF1_HUMANS26A6_HUMANIntAct12444019 details
NHRF1_HUMANAPBP2_HUMANBioGRID, IntAct32296183 details
NHRF1_HUMANDLGP4_HUMANBioGRID, IntAct32296183 details
NHRF1_HUMANRABP1_HUMANBioGRID, IntAct32296183 details
NHRF1_HUMANFA20C_HUMANIntAct22582013 details
NHRF1_HUMANNHRF1_HUMANBioGRID, DIP11046132 15070904 19446522 details
NHRF1_HUMANKCNJ1_HUMANBioGRID, HPRD14604981 details
NHRF1_HUMANSL9A3_HUMANBioGRID, HPRD14580213 details
NHRF1_HUMANNHRF3_HUMANBioGRID14531806 details
NHRF1_HUMANCTNB1_HUMANBioGRID, HPRD12830000 details
NHRF1_HUMANMRP2_HUMANBioGRID, HPRD12615054 25163515 details
NHRF1_HUMANS4A8_HUMANBioGRID, HPRD12444018 details
NHRF1_HUMANNOS2_HUMANBioGRID, HPRD12080081 details
NHRF1_HUMANPTH1R_HUMANBioGRID, HPRD12075354 details
NHRF1_HUMANPGFRA_HUMANBioGRID, HPRD11046132 11882663 details
NHRF1_HUMANSCN4A_HUMANBioGRID9677412 details
NHRF1_HUMANMRP4_HUMANBioGRID18045536 18559527 details
NHRF1_HUMANGNA11_HUMANBioGRID12193606 details
NHRF1_HUMANSKP2_HUMANBioGRID25492869 details
NHRF1_HUMANAKT1_HUMANBioGRID25492869 details
NHRF1_HUMANS4A7_HUMANBioGRID12403779 details
NHRF1_HUMANKPCA_HUMANBioGRID12954600 details
NHRF1_HUMANS13A1_HUMANBioGRID18407958 details
NHRF1_HUMANGRM2_HUMANBioGRID28392297 details
NHRF1_HUMANGRM3_HUMANBioGRID28392297 details
NHRF1_HUMANOGT1_HUMANBioGRID32994395 details
NHRF1_HUMANCNGA2_HUMANHPRD14604981 details
NHRF1_HUMANS22AB_HUMANHPRD16236806 details
NHRF1_HUMANS22A4_HUMANHPRD15553237 details
NHRF1_HUMANS22A5_HUMANHPRD15553237 details
NHRF1_HUMANS22A9_HUMANHPRD15553237 details
NHRF1_HUMANSO1A2_HUMANHPRD15553237 details
NHRF1_HUMANSO3A1_HUMANHPRD15553237 details
NHRF1_HUMANPLCB3_HUMANMINT11285285 details
NHRF1_HUMANCAN6_HUMANMINT11285285 details
NHRF1_HUMANPTPRQ_HUMANIntActunassigned1312 details
NHRF1_HUMANPLCB1_HUMANBioGRID, HPRD10980202 12193606 details
NHRF1_HUMANRACK1_HUMANBioGRID11956211 details
NHRF1_HUMANEPHB1_HUMANBioGRID23118026 details
NHRF1_HUMANU2AF2_HUMANBioGRID26641092 details
NHRF1_HUMANMK01_HUMANBioGRID20736378 details
NHRF1_HUMANCADH2_HUMANBioGRID20736378 details
NHRF1_HUMANRADI_HUMANHPRD12499563 9430655 details
NHRF1_HUMANVATB1_HUMANHPRD10748165 details
NHRF1_HUMANVATE1_HUMANHPRD10748165 details
NHRF1_HUMANTRPC5_HUMANHPRD10980202 details
NHRF1_HUMANGRK6_HUMANHPRD10446210 details
NHRF1_HUMANGNAQ_HUMANHPRD12193606 details
NHRF1_HUMANPLCB2_HUMANHPRD10980202 details
NHRF1_HUMANAKA10_HUMANHPRD14531806 details
NHRF1_HUMANNPT2A_HUMANHPRD11099500 details
NHRF1_HUMANTRPC4_HUMANHPRD10980202 details
NHRF1_HUMANLSHR_HUMANHPRD14507927 details
NHRF1_HUMANRLBP1_HUMANHPRD14744877 details
NHRF1_HUMANS26A3_HUMANHPRD12369822 details
NHRF1_HUMANEGFR_HUMANHPRD16456542 details
NHRF1_HUMANLPAR2_HUMANHPRD16203867 details