Entity Details

Primary name TR10B_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO14763
EntryNameTR10B_HUMAN
FullNameTumor necrosis factor receptor superfamily member 10B
TaxID9606
Evidenceevidence at protein level
Length440
SequenceStatuscomplete
DateCreated2001-09-26
DateModified2021-06-02

Ontological Relatives

GenesTNFRSF10B

GO terms

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GOName
GO:0005886 plasma membrane
GO:0006915 apoptotic process
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007166 cell surface receptor signaling pathway
GO:0007250 activation of NF-kappaB-inducing kinase activity
GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors
GO:0009986 cell surface
GO:0016021 integral component of membrane
GO:0034976 response to endoplasmic reticulum stress
GO:0036462 TRAIL-activated apoptotic signaling pathway
GO:0036463 TRAIL receptor activity
GO:0038023 signaling receptor activity
GO:0042981 regulation of apoptotic process
GO:0043065 positive regulation of apoptotic process
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045569 TRAIL binding
GO:0050900 leukocyte migration
GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0071260 cellular response to mechanical stimulus
GO:1902041 regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors

Subcellular Location

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Subcellular Location
Membrane

Domains

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DomainNameCategoryType
IPR000488 Death domainDomainDomain
IPR001368 TNFR/NGFR cysteine-rich regionDomainDomain
IPR011029 Death-like domain superfamilyFamilyHomologous superfamily
IPR020465 Tumour necrosis factor receptor 10FamilyFamily
IPR034024 Tumor necrosis factor receptor 10, N-terminalDomainDomain
IPR034029 Tumour necrosis factor receptor 10A/B, death domainDomainDomain

Diseases

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Disease IDSourceNameDescription
275355 OMIMSquamous cell carcinoma of the head and neck (HNSCC)A non-melanoma skin cancer affecting the head and neck. The hallmark of cutaneous SCC is malignant transformation of normal epidermal keratinocytes. The disease may be caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB05895 HGS-TR2JDrugbankbiotech
DB06599 LexatumumabDrugbankbiotech

Interactions

39 interactions

InteractorPartnerSourcesPublicationsLink
TR10B_HUMANTNF10_HUMANBioGRID, HPRD, IntAct, MINT10542098 10549288 10894160 11094155 16554480 19427028 19432816 20097879 20103630 21459798 21525171 21822306 22266862 22585859 23678861 25551360 9311998 9325248 details
TR10B_HUMANCASP8_HUMANBioGRID, HPRD, IntAct11940602 12218097 15388581 15659383 17047155 19343040 19432816 20103630 23142077 25043603 26186194 28514442 28972304 31443721 32313199 9325248 details
TR10B_HUMANASPH_HUMANBioGRID, IntAct32296183 details
TR10B_HUMANMUC1_HUMANBioGRID, IntAct32296183 details
TR10B_HUMANZDH15_HUMANBioGRID, IntAct32296183 details
TR10B_HUMANTIM50_HUMANBioGRID15044455 details
TR10B_HUMANTMM31_HUMANBioGRID32296183 details
TR10B_HUMANCDC42_HUMANBioGRID31478661 details
TR10B_HUMANARAP1_HUMANIntAct18165900 details
TR10B_HUMANTR10A_HUMANBioGRID, HPRD, IntAct15388581 16319225 19427028 28514442 29795330 9430228 details
TR10B_HUMANFADD_HUMANBioGRID, HPRD, IntAct11940602 15388581 15659383 23142077 25043603 26186194 28514442 28972304 31443721 32313199 9430227 details
TR10B_HUMANRAC1_HUMANIntAct25843002 details
TR10B_HUMANBID_HUMANBioGRID15659383 details
TR10B_HUMANEZRI_HUMANBioGRID15659383 details
TR10B_HUMANTNR6_HUMANBioGRID15659383 details
TR10B_HUMANTNFL6_HUMANBioGRID15659383 details
TR10B_HUMANMK08_HUMANBioGRID15659383 details
TR10B_HUMANMOES_HUMANBioGRID15659383 details
TR10B_HUMANCASPA_HUMANBioGRID15659383 9325248 details
TR10B_HUMANRHOA_HUMANBioGRID15659383 details
TR10B_HUMANGDIR1_HUMANBioGRID15659383 details
TR10B_HUMANTNR1A_HUMANBioGRID15659383 details
TR10B_HUMANCFLAR_HUMANBioGRID, HPRD11193041 11940602 19343040 23142077 32313199 9325248 details
TR10B_HUMANTRADD_HUMANBioGRID, HPRD9430227 details
TR10B_HUMANRIPK1_HUMANBioGRID, HPRD22585859 32313199 9430227 details
TR10B_HUMANCBL_HUMANBioGRID19932172 28972304 details
TR10B_HUMANITCH_HUMANBioGRID19808964 details
TR10B_HUMANTNAP3_HUMANBioGRID22585859 details
TR10B_HUMANTRAF2_HUMANBioGRID22585859 23142077 32313199 details
TR10B_HUMANCUL3_HUMANBioGRID23142077 32313199 details
TR10B_HUMANCBLB_HUMANBioGRID28972304 details
TR10B_HUMANCAV1_HUMANBioGRID19432816 details
TR10B_HUMANRN183_HUMANBioGRID31889078 details
TR10B_HUMANCUL1_HUMANBioGRID32313199 details
TR10B_HUMANSKP2_HUMANBioGRID32313199 details
TR10B_HUMANSKP1_HUMANBioGRID32313199 details
TR10B_HUMANRBX1_HUMANBioGRID32313199 details
TR10B_HUMANMADD_HUMANHPRD15208670 details
TR10B_HUMANTR10D_HUMANHPRD16319225 details