Entity Details

Primary name I17RA_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ96F46
EntryNameI17RA_HUMAN
FullNameInterleukin-17 receptor A
TaxID9606
Evidenceevidence at protein level
Length866
SequenceStatuscomplete
DateCreated2002-05-02
DateModified2021-06-02

Ontological Relatives

GenesIL17RA

GO terms

Show/Hide Table
GOName
GO:0002250 adaptive immune response
GO:0005576 extracellular region
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006954 inflammatory response
GO:0007166 cell surface receptor signaling pathway
GO:0030368 interleukin-17 receptor activity
GO:0032747 positive regulation of interleukin-23 production
GO:0032755 positive regulation of interleukin-6 production
GO:0045087 innate immune response
GO:0072537 fibroblast activation
GO:0097400 interleukin-17-mediated signaling pathway
GO:2000340 positive regulation of chemokine (C-X-C motif) ligand 1 production

Subcellular Location

Show/Hide Table
Subcellular Location
Cell membrane
Secreted

Domains

Show/Hide Table
DomainNameCategoryType
IPR013568 SEFIR domainDomainDomain
IPR032356 Interleukin-17 receptor, fibronectin-III-like domain 1DomainDomain
IPR038683 Interleukin-17 receptor A/B, FnIII-like domain 1 superfamilyFamilyHomologous superfamily
IPR039465 Interleukin-17 receptor-likeFamilyFamily
IPR043046 Interleukin-17 receptor A/B, FnIII-like domain 2 superfamilyFamilyHomologous superfamily

Diseases

Show/Hide Table
Disease IDSourceNameDescription
613953 OMIMImmunodeficiency 51 (IMD51)A primary immunodeficiency disorder with altered immune responses and impaired clearance of fungal infections, selective against Candida. It is characterized by persistent and/or recurrent infections of the skin, nails and mucous membranes caused by organisms of the genus Candida, mainly Candida albicans. The disease is caused by variants affecting the gene represented in this entry.