Entity Details

Primary name GDF8_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO14793
EntryNameGDF8_HUMAN
FullNameGrowth/differentiation factor 8
TaxID9606
Evidenceevidence at protein level
Length375
SequenceStatuscomplete
DateCreated1999-07-15
DateModified2021-06-02

Ontological Relatives

GenesMSTN

GO terms

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GOName
GO:0005102 signaling receptor binding
GO:0005125 cytokine activity
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007517 muscle organ development
GO:0008083 growth factor activity
GO:0008201 heparin binding
GO:0009408 response to heat
GO:0009629 response to gravity
GO:0010592 positive regulation of lamellipodium assembly
GO:0010759 positive regulation of macrophage chemotaxis
GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0014732 skeletal muscle atrophy
GO:0014741 negative regulation of muscle hypertrophy
GO:0014839 myoblast migration involved in skeletal muscle regeneration
GO:0014850 response to muscle activity
GO:0022602 ovulation cycle process
GO:0033574 response to testosterone
GO:0033673 negative regulation of kinase activity
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0043627 response to estrogen
GO:0045471 response to ethanol
GO:0045662 negative regulation of myoblast differentiation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0046627 negative regulation of insulin receptor signaling pathway
GO:0046716 muscle cell cellular homeostasis
GO:0048632 negative regulation of skeletal muscle tissue growth
GO:0051602 response to electrical stimulus
GO:0051898 negative regulation of protein kinase B signaling
GO:0060395 SMAD protein signal transduction
GO:0071549 cellular response to dexamethasone stimulus
GO:1902723 negative regulation of skeletal muscle satellite cell proliferation
GO:1902725 negative regulation of satellite cell differentiation
GO:2000818 negative regulation of myoblast proliferation

Subcellular Location

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Subcellular Location
Secreted

Domains

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DomainNameCategoryType
IPR001111 TGF-beta, propeptideDomainDomain
IPR001839 Transforming growth factor-beta, C-terminalDomainDomain
IPR015615 Transforming growth factor-beta-relatedFamilyFamily
IPR015616 Growth/differentiation factor 8FamilyFamily
IPR017948 Transforming growth factor beta, conserved siteSiteConserved site
IPR029034 Cystine-knot cytokineFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
614160 OMIMMuscle hypertrophy (MSLHP)A condition characterized by increased muscle bulk and strength. Affected individuals are exceptionally strong. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB05915 MYO-029Drugbankbiotech