Entity Details

Primary name WNK4_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ96J92
EntryNameWNK4_HUMAN
FullNameSerine/threonine-protein kinase WNK4
TaxID9606
Evidenceevidence at protein level
Length1243
SequenceStatuscomplete
DateCreated2004-02-02
DateModified2021-06-02

Ontological Relatives

GenesWNK4

GO terms

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GOName
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005923 bicellular tight junction
GO:0006468 protein phosphorylation
GO:0006811 ion transport
GO:0006821 chloride transport
GO:0008104 protein localization
GO:0010766 negative regulation of sodium ion transport
GO:0016020 membrane
GO:0019869 chloride channel inhibitor activity
GO:0019870 potassium channel inhibitor activity
GO:0035556 intracellular signal transduction
GO:0050794 regulation of cellular process
GO:0050801 ion homeostasis
GO:0070294 renal sodium ion absorption
GO:0072156 distal tubule morphogenesis
GO:0090188 negative regulation of pancreatic juice secretion
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:1903288 positive regulation of potassium ion import across plasma membrane
GO:2000651 positive regulation of sodium ion transmembrane transporter activity

Subcellular Location

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Subcellular Location
Cell junction

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR024678 Serine/threonine-protein kinase OSR1/WNK, CCT domainDomainDomain

Diseases

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Disease IDSourceNameDescription
614491 OMIMPseudohypoaldosteronism 2B (PHA2B)An autosomal dominant disorder characterized by hypertension, hyperkalemia, hyperchloremia, mild hyperchloremic metabolic acidosis, and correction of physiologic abnormalities by thiazide diuretics. The disease is caused by variants affecting the gene represented in this entry.