Entity Details

Primary name NED4L_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ96PU5
EntryNameNED4L_HUMAN
FullNameE3 ubiquitin-protein ligase NEDD4-like
TaxID9606
Evidenceevidence at protein level
Length975
SequenceStatuscomplete
DateCreated2005-08-30
DateModified2021-06-02

Ontological Relatives

GenesNEDD4L

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000209 protein polyubiquitination
GO:0003254 regulation of membrane depolarization
GO:0004842 ubiquitin-protein transferase activity
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005771 multivesicular body
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0006814 sodium ion transport
GO:0006883 cellular sodium ion homeostasis
GO:0007588 excretion
GO:0010038 response to metal ion
GO:0015459 potassium channel regulator activity
GO:0016567 protein ubiquitination
GO:0017080 sodium channel regulator activity
GO:0019058 viral life cycle
GO:0019870 potassium channel inhibitor activity
GO:0019871 sodium channel inhibitor activity
GO:0030104 water homeostasis
GO:0030154 cell differentiation
GO:0031647 regulation of protein stability
GO:0034220 ion transmembrane transport
GO:0034765 regulation of ion transmembrane transport
GO:0042176 regulation of protein catabolic process
GO:0042391 regulation of membrane potential
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0044325 transmembrane transporter binding
GO:0045732 positive regulation of protein catabolic process
GO:0045807 positive regulation of endocytosis
GO:0048814 regulation of dendrite morphogenesis
GO:0060306 regulation of membrane repolarization
GO:0061630 ubiquitin protein ligase activity
GO:0070062 extracellular exosome
GO:0070936 protein K48-linked ubiquitination
GO:0086005 ventricular cardiac muscle cell action potential
GO:1901016 regulation of potassium ion transmembrane transporter activity
GO:1901017 negative regulation of potassium ion transmembrane transporter activity
GO:1901380 negative regulation of potassium ion transmembrane transport
GO:1902306 negative regulation of sodium ion transmembrane transport
GO:1903861 positive regulation of dendrite extension
GO:2000009 negative regulation of protein localization to cell surface
GO:2000650 negative regulation of sodium ion transmembrane transporter activity
GO:2001288 positive regulation of caveolin-mediated endocytosis

Subcellular Location

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Subcellular Location
Cytoplasm
Endosome
Golgi apparatus

Domains

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DomainNameCategoryType
IPR000008 C2 domainDomainDomain
IPR000569 HECT domainDomainDomain
IPR001202 WW domainDomainDomain
IPR024928 E3 ubiquitin-protein ligase, SMURF1 typeFamilyFamily
IPR035892 C2 domain superfamilyFamilyHomologous superfamily
IPR035983 HECT, E3 ligase catalytic domainFamilyHomologous superfamily
IPR036020 WW domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
617201 OMIMPeriventricular nodular heterotopia 7 (PVNH7)A form of periventricular nodular heterotopia, a disorder resulting from a defect in the pattern of neuronal migration in which ectopic collections of neurons lie along the lateral ventricles of the brain or just beneath, contiguously or in isolated patches. PVNH7 is an autosomal dominant disease characterized by delayed psychomotor development, intellectual disability, and seizures in some patients. Additional features include cleft palate and toe syndactyly. The disease is caused by variants affecting the gene represented in this entry.

Interactions

188 interactions

InteractorPartnerSourcesPublicationsLink
NED4L_HUMANRNF11_HUMANBioGRID, HPRD, MINT15231748 28292929 details
NED4L_HUMANSMAD2_HUMANBioGRID, MINT15231748 19917253 26555259 details
NED4L_HUMANLAPM5_HUMANBioGRID, HPRD, MINT15231748 details
NED4L_HUMANGDIR1_HUMANBioGRID, HPRD, IntAct16169070 details
NED4L_HUMAN1433Z_HUMANBioGRID, MINT15161933 20936779 details
NED4L_HUMANMED28_HUMANBioGRID, MINT16964398 details
NED4L_HUMANUBC_HUMANBioGRID, MINT19343052 20064473 22496338 23644597 25752577 28461335 29964046 details
NED4L_HUMANAMOT_HUMANBioGRID, IntAct, MINT19615732 24981860 25633977 details
NED4L_HUMAN1433G_HUMANBioGRID, IntAct20936779 28514442 details
NED4L_HUMANWNK1_HUMANBioGRID, IntAct20525693 20936779 26241057 details
NED4L_HUMANAATF_HUMANBioGRID, IntAct21988832 details
NED4L_HUMANGORAB_HUMANBioGRID, IntAct21988832 details
NED4L_HUMANRPGF2_HUMANMINT21765395 details
NED4L_HUMANSCNNB_HUMANBioGRID, HPRD, MINT11244092 11802777 12876068 15328345 15814530 16416336 16844684 18322022 18498246 19380724 21765395 details
NED4L_HUMANDAZP2_HUMANBioGRID, IntAct25416956 32296183 details
NED4L_HUMANARRD3_HUMANBioGRID, IntAct23236378 28514442 29416926 32296183 details
NED4L_HUMANSMAD3_HUMANBioGRID, DIP19917253 22921829 24071738 26555259 details
NED4L_HUMANSMAD7_HUMANBioGRID, DIP22773947 22921829 details
NED4L_HUMANGCR_HUMANBioGRID9649342 details
NED4L_HUMANSCNNA_HUMANBioGRID, HPRD11244092 11802777 12876068 14556380 15328345 16416336 16844684 17502380 18322022 18498246 18701608 26651153 details
NED4L_HUMANSCNNG_HUMANBioGRID, HPRD11244092 11802777 12876068 15328345 16416336 16716084 16844684 18322022 18498246 details
NED4L_HUMANNED4L_HUMANBioGRID, HPRD17719543 18498246 18656546 19153599 20542005 21396940 22496338 23695783 25527291 26949039 28972136 30021006 30587574 details
NED4L_HUMANPSMD4_HUMANBioGRID20542005 details
NED4L_HUMANACK1_HUMANBioGRID19144635 23686771 details
NED4L_HUMANKCNB1_HUMANBioGRID19953087 details
NED4L_HUMANMAPK3_HUMANBioGRID19953087 details
NED4L_HUMANCLIC2_HUMANBioGRID19953087 details
NED4L_HUMANFBLN4_HUMANBioGRID19953087 details
NED4L_HUMANHGS_HUMANBioGRID19953087 20675381 details
NED4L_HUMANNFIP2_HUMANBioGRID, HPRD12050153 15252135 19953087 details
NED4L_HUMANM3K3_HUMANBioGRID19953087 details
NED4L_HUMANVDAC2_HUMANBioGRID19953087 details
NED4L_HUMANZDHC3_HUMANBioGRID19953087 details
NED4L_HUMANKCC1D_HUMANBioGRID19953087 details
NED4L_HUMANRBP10_HUMANBioGRID19953087 details
NED4L_HUMANCDK5_HUMANBioGRID19953087 details
NED4L_HUMANABL1_HUMANBioGRID19953087 details
NED4L_HUMANMAGB1_HUMANBioGRID19953087 details
NED4L_HUMANDEMA_HUMANBioGRID19953087 details
NED4L_HUMANAICDA_HUMANBioGRID19953087 details
NED4L_HUMANMARK2_HUMANBioGRID19953087 details
NED4L_HUMANKCAB1_HUMANBioGRID19953087 details
NED4L_HUMANFKBP3_HUMANBioGRID19953087 details
NED4L_HUMANDAPK3_HUMANBioGRID19953087 details
NED4L_HUMANBRAF_HUMANBioGRID19953087 31015455 details
NED4L_HUMANM3K5_HUMANBioGRID19953087 details
NED4L_HUMANDDX54_HUMANBioGRID19953087 details
NED4L_HUMANM3K20_HUMANBioGRID19953087 details
NED4L_HUMANKCAB3_HUMANBioGRID19953087 details
NED4L_HUMANNTRK1_HUMANBioGRID, HPRD16701206 19953087 details
NED4L_HUMANCUED1_HUMANBioGRID19953087 details
NED4L_HUMANKS6B2_HUMANBioGRID19953087 details
NED4L_HUMANABL2_HUMANBioGRID19953087 details
NED4L_HUMANCACB1_HUMANBioGRID19953087 details
NED4L_HUMANTYY1_HUMANBioGRID19953087 details
NED4L_HUMANM3K2_HUMANBioGRID19953087 details
NED4L_HUMANBBX_HUMANBioGRID19953087 details
NED4L_HUMANPRKX_HUMANBioGRID19953087 details
NED4L_HUMANACV1B_HUMANBioGRID19953087 details
NED4L_HUMANADAP2_HUMANBioGRID19953087 details
NED4L_HUMANBMR1A_HUMANBioGRID19953087 details
NED4L_HUMANAKT3_HUMANBioGRID19953087 details
NED4L_HUMANMINK1_HUMANBioGRID19953087 details
NED4L_HUMANAURKC_HUMANBioGRID19953087 details
NED4L_HUMANNSRP1_HUMANBioGRID19953087 details
NED4L_HUMANPYM1_HUMANBioGRID19953087 details
NED4L_HUMANSGK2_HUMANBioGRID19953087 details
NED4L_HUMANUBAC1_HUMANBioGRID19953087 details
NED4L_HUMANRL30_HUMANBioGRID19953087 details
NED4L_HUMANMERTK_HUMANBioGRID19953087 details
NED4L_HUMANSRMS_HUMANBioGRID19953087 details
NED4L_HUMANPEDF_HUMANBioGRID19953087 details
NED4L_HUMANDYRK3_HUMANBioGRID19953087 details
NED4L_HUMANIFRD2_HUMANBioGRID19953087 details
NED4L_HUMANSCD_HUMANBioGRID19953087 details
NED4L_HUMANROBO3_HUMANBioGRID19953087 details
NED4L_HUMANTRI41_HUMANBioGRID19953087 details
NED4L_HUMANTMA16_HUMANBioGRID19953087 details
NED4L_HUMANTAF1B_HUMANBioGRID19953087 details
NED4L_HUMANSPAG8_HUMANBioGRID19953087 details
NED4L_HUMANSTAC_HUMANBioGRID19953087 details
NED4L_HUMANH10_HUMANBioGRID19953087 details
NED4L_HUMANLARGN_HUMANBioGRID19953087 details
NED4L_HUMANKIFC3_HUMANBioGRID19953087 details
NED4L_HUMANRSLAB_HUMANBioGRID19953087 details
NED4L_HUMANTMG1_HUMANBioGRID19953087 details
NED4L_HUMANCDK3_HUMANBioGRID19953087 details
NED4L_HUMANKCAB2_HUMANBioGRID19953087 details
NED4L_HUMANFGF12_HUMANBioGRID19953087 details
NED4L_HUMANRBX2_HUMANBioGRID19953087 details
NED4L_HUMANAPEX2_HUMANBioGRID19953087 details
NED4L_HUMANRM19_HUMANBioGRID19953087 details
NED4L_HUMANTGFI1_HUMANBioGRID19953087 details
NED4L_HUMANTBCD7_HUMANBioGRID19953087 details
NED4L_HUMANNHP2_HUMANBioGRID19953087 details
NED4L_HUMANPP4P2_HUMANBioGRID19953087 details
NED4L_HUMANCP26B_HUMANBioGRID19953087 details
NED4L_HUMANDECR2_HUMANBioGRID19953087 details
NED4L_HUMANSENP2_HUMANBioGRID19953087 details
NED4L_HUMANSIVA_HUMANBioGRID19953087 details
NED4L_HUMANRSLBB_HUMANBioGRID19953087 details
NED4L_HUMANMTAP2_HUMANBioGRID19953087 details
NED4L_HUMANSTK40_HUMANBioGRID19953087 details
NED4L_HUMANTIRR_HUMANBioGRID19953087 details
NED4L_HUMANCG050_HUMANBioGRID19953087 details
NED4L_HUMANTCAL2_HUMANBioGRID19953087 details
NED4L_HUMANZCCHL_HUMANBioGRID19953087 details
NED4L_HUMANMOB3A_HUMANBioGRID19953087 details
NED4L_HUMANTRBP2_HUMANBioGRID19953087 details
NED4L_HUMANPTGR3_HUMANBioGRID19953087 details
NED4L_HUMANWBP2_HUMANBioGRID19953087 27182664 27578003 details
NED4L_HUMANSGK1_HUMANBioGRID, HPRD11742982 12729930 12911626 16006511 16716084 19917253 20525693 20730100 23589291 details
NED4L_HUMANWNK4_HUMANBioGRID20525693 details
NED4L_HUMANIKKB_HUMANBioGRID18981174 details
NED4L_HUMANUB2D2_HUMANBioGRID19953087 20064473 20542005 22496338 23695783 27182664 27932573 28972136 29643511 33282879 details
NED4L_HUMANNPC2_HUMANBioGRID19664597 details
NED4L_HUMANMT2_HUMANBioGRID19664597 details
NED4L_HUMANAT1B1_HUMANBioGRID19664597 details
NED4L_HUMANCYBR1_HUMANBioGRID19664597 details
NED4L_HUMANYLAT1_HUMANBioGRID19664597 details
NED4L_HUMANPBX1_HUMANBioGRID19664597 details
NED4L_HUMANACY3_HUMANBioGRID19664597 details
NED4L_HUMANHAX1_HUMANBioGRID19664597 details
NED4L_HUMANKIF3B_HUMANBioGRID19664597 details
NED4L_HUMANUB2L3_HUMANBioGRID, HPRD18498246 23695783 25527291 25752577 26949039 27182664 29643511 30587574 33282879 8576257 9575161 details
NED4L_HUMANUBE2K_HUMANBioGRID17429078 22496338 details
NED4L_HUMANUB2D1_HUMANBioGRID21396940 24071738 28972136 33282879 9575161 details
NED4L_HUMANUB2E3_HUMANBioGRID22496338 23695783 28972136 details
NED4L_HUMANUB2J2_HUMANBioGRID22496338 details
NED4L_HUMANUB2R1_HUMANBioGRID22496338 details
NED4L_HUMANUB2D3_HUMANBioGRID23644597 23695783 27339899 28972136 30021006 33282879 details
NED4L_HUMANUBE2N_HUMANBioGRID24071738 details
NED4L_HUMANSYUA_HUMANBioGRID24831002 30021006 details
NED4L_HUMANRHOB_HUMANBioGRID26949039 details
NED4L_HUMANULK1_HUMANBioGRID27932573 31959741 details
NED4L_HUMANGRIA1_HUMANBioGRID28212375 details
NED4L_HUMANSCN5A_HUMANBioGRID, HPRD15217910 15548568 28296171 31900993 details
NED4L_HUMANUB2E1_HUMANBioGRID, HPRD28972136 33282879 8576257 details
NED4L_HUMANUB2E2_HUMANBioGRID28972136 details
NED4L_HUMANUB2L6_HUMANBioGRID28972136 details
NED4L_HUMANPK3CA_HUMANBioGRID27339899 details
NED4L_HUMANBEST1_HUMANBioGRID31036321 details
NED4L_HUMANFOXO1_HUMANBioGRID31844113 details
NED4L_HUMANPINK1_HUMANBioGRID32140098 details
NED4L_HUMANTMG4_HUMANBioGRID23873930 details
NED4L_HUMANTMG2_HUMANBioGRID23873930 details
NED4L_HUMANSP1_HUMANBioGRID32724456 details
NED4L_HUMANOGG1_HUMANBioGRID33282879 details
NED4L_HUMAN1433S_HUMANBioGRID, MINT15778465 details
NED4L_HUMANSTIP1_HUMANMINT15778465 details
NED4L_HUMAN1433F_HUMANBioGRID, IntAct, MINT15677482 16716084 28514442 details
NED4L_HUMANFXL15_HUMANBioGRID, MINT21572392 details
NED4L_HUMANLITAF_HUMANBioGRID, IntAct25963657 28514442 details
NED4L_HUMANOCLN_HUMANBioGRID, IntAct20504882 28514442 details
NED4L_HUMANNRAM2_HUMANDIP19706893 details
NED4L_HUMAN1433B_HUMANBioGRID20338996 details
NED4L_HUMANAPBB1_HUMANBioGRID19381069 details
NED4L_HUMANNFIP1_HUMANBioGRID22213801 details
NED4L_HUMANRAF1_HUMANBioGRID19380724 details
NED4L_HUMANT22D3_HUMANBioGRID19380724 details
NED4L_HUMANAMOL1_HUMANBioGRID22558212 33058421 details
NED4L_HUMAN1433T_HUMANBioGRID21900244 23444366 details
NED4L_HUMANKCNH2_HUMANBioGRID22879586 24688054 details
NED4L_HUMANCAV3_HUMANBioGRID22879586 details
NED4L_HUMANKCNQ1_HUMANBioGRID23529131 26405101 32173736 details
NED4L_HUMANSGK3_HUMANBioGRID23589291 details
NED4L_HUMANNOTC1_HUMANBioGRID23886940 details
NED4L_HUMANHCN1_HUMANBioGRID24451387 details
NED4L_HUMANSMAD6_HUMANBioGRID24850914 details
NED4L_HUMANSL9A3_HUMANBioGRID24831004 details
NED4L_HUMANWNK3_HUMANBioGRID24920754 details
NED4L_HUMANPTC1_HUMANBioGRID25092867 details
NED4L_HUMANS22AB_HUMANBioGRID26740304 30453017 details
NED4L_HUMANS22A8_HUMANBioGRID26651153 details
NED4L_HUMANCRYAB_HUMANBioGRID26961874 details
NED4L_HUMANGRB10_HUMANBioGRID27146988 27742835 details
NED4L_HUMANKCNA3_HUMANBioGRID27146988 details
NED4L_HUMANERBB3_HUMANBioGRID27793840 details
NED4L_HUMANFAK2_HUMANBioGRID27793840 details
NED4L_HUMANLPAR1_HUMANBioGRID27448760 details
NED4L_HUMANS22A6_HUMANBioGRID28572241 details
NED4L_HUMANIL2RG_HUMANBioGRID27742835 details
NED4L_HUMANIL4RA_HUMANBioGRID27742835 details
NED4L_HUMANPKHD1_HUMANBioGRID28798345 details
NED4L_HUMANCRTC3_HUMANBioGRID29505301 details
NED4L_HUMANMERL_HUMANBioGRID33058421 details
NED4L_HUMANSTK35_HUMANBioGRID33117809 details
NED4L_HUMANSCAM3_HUMANHPRD19158374 details