Entity Details

Primary name MYPT1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO14974
EntryNameMYPT1_HUMAN
FullNameProtein phosphatase 1 regulatory subunit 12A
TaxID9606
Evidenceevidence at protein level
Length1030
SequenceStatuscomplete
DateCreated2004-01-16
DateModified2021-06-02

Ontological Relatives

GenesPPP1R12A

GO terms

Show/Hide Table
GOName
GO:0000086 G2/M transition of mitotic cell cycle
GO:0000278 mitotic cell cycle
GO:0000776 kinetochore
GO:0004857 enzyme inhibitor activity
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005925 focal adhesion
GO:0006470 protein dephosphorylation
GO:0007098 centrosome cycle
GO:0007165 signal transduction
GO:0015629 actin cytoskeleton
GO:0019208 phosphatase regulator activity
GO:0019901 protein kinase binding
GO:0030018 Z disc
GO:0030155 regulation of cell adhesion
GO:0031672 A band
GO:0035507 regulation of myosin-light-chain-phosphatase activity
GO:0035508 positive regulation of myosin-light-chain-phosphatase activity
GO:0035690 cellular response to drug
GO:0043086 negative regulation of catalytic activity
GO:0043292 contractile fiber
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046822 regulation of nucleocytoplasmic transport
GO:0071889 14-3-3 protein binding
GO:0072357 PTW/PP1 phosphatase complex

Subcellular Location

Show/Hide Table
Subcellular Location
Cytoplasm

Domains

Show/Hide Table
DomainNameCategoryType
IPR002110 Ankyrin repeatRepeatRepeat
IPR017401 Protein phosphatase 1 regulatory subunit 12A/B/CFamilyFamily
IPR020683 Ankyrin repeat-containing domainDomainDomain
IPR031775 cGMP-dependent protein kinase, interacting domainDomainDomain
IPR036770 Ankyrin repeat-containing domain superfamilyFamilyHomologous superfamily

Diseases

Show/Hide Table
Disease IDSourceNameDescription
618820 OMIMGenitourinary and/or brain malformation syndrome (GUBS)An autosomal dominant syndrome characterized by multiple congenital anomalies including urogenital malformations and brain abnormalities ranging from agenesis of the corpus callosum to anencephaly. The disease is caused by variants affecting the gene represented in this entry.

Interactions

35 interactions

InteractorPartnerSourcesPublicationsLink
MYPT1_HUMANDMPK_HUMANHPRD, MINT10601309 11287000 11931630 12220642 12600888 21457715 details
MYPT1_HUMANMPRIP_HUMANHPRD, MINT15545284 16243315 details
MYPT1_HUMANFYN_HUMANIntAct17474147 details
MYPT1_HUMANPTPRJ_HUMANIntAct19167335 details
MYPT1_HUMANHIF1N_HUMANDIP17003112 details
MYPT1_HUMANATX10_HUMANBioGRID, IntAct16498633 32814053 details
MYPT1_HUMANIL16_HUMANBioGRID, HPRD12923170 details
MYPT1_HUMANKGP1_HUMANBioGRID, HPRD10567269 details
MYPT1_HUMANKDM1A_HUMANBioGRID21115810 details
MYPT1_HUMANSETD7_HUMANBioGRID21115810 details
MYPT1_HUMANSIAH2_HUMANBioGRID19744480 details
MYPT1_HUMANLATS1_HUMANBioGRID22641346 details
MYPT1_HUMANCDKN3_HUMANBioGRID24704824 details
MYPT1_HUMANM3K3_HUMANIntAct14743216 details
MYPT1_HUMANRIPK3_HUMANIntAct14743216 details
MYPT1_HUMANPP1B_HUMANBioGRID, IntAct17353931 26496610 27173435 28330616 unassigned1312 details
MYPT1_HUMANFOS_HUMANBioGRID, IntAct, MINT20195357 25609649 details
MYPT1_HUMANKAP0_HUMANIntAct20195357 details
MYPT1_HUMAN1433Z_HUMANMINT18094049 details
MYPT1_HUMANRHOA_HUMANBioGRID, HPRD, MINT15545284 22939629 9354661 details
MYPT1_HUMANRAN_HUMANIntAct24855949 details
MYPT1_HUMANDAPK3_HUMANUniProt15292222 details
MYPT1_HUMAN1433G_HUMANHPRD, IntAct15324660 28514442 details
MYPT1_HUMANHDAC7_HUMANBioGRID17369396 details
MYPT1_HUMANNUAK1_HUMANBioGRID24785407 details
MYPT1_HUMANCASR_HUMANBioGRID19245366 details
MYPT1_HUMANPP1G_HUMANBioGRID30344098 details
MYPT1_HUMANSOX2_HUMANBioGRID21280222 details
MYPT1_HUMANNACA_HUMANBioGRID30948508 details
MYPT1_HUMANNACAM_HUMANBioGRID30948508 details
MYPT1_HUMANKIF23_HUMANBioGRID31586073 details
MYPT1_HUMANISG15_HUMANBioGRID33024031 details
MYPT1_HUMANROCK1_HUMANHPRD10601309 11931630 12220642 12563012 12600888 9354661 details
MYPT1_HUMANILK_HUMANHPRD10601309 11931630 12220642 12600888 details
MYPT1_HUMANROCK2_HUMANHPRD10601309 11931630 12220642 12563012 12600888 details