Entity Details

Primary name S26A8_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ96RN1
EntryNameS26A8_HUMAN
FullNameTestis anion transporter 1
TaxID9606
Evidenceevidence at protein level
Length970
SequenceStatuscomplete
DateCreated2008-02-26
DateModified2021-06-02

Ontological Relatives

GenesSLC26A8

GO terms

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GOName
GO:0005254 chloride channel activity
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006820 anion transport
GO:0006821 chloride transport
GO:0007275 multicellular organism development
GO:0008271 secondary active sulfate transmembrane transporter activity
GO:0008272 sulfate transport
GO:0015106 bicarbonate transmembrane transporter activity
GO:0015108 chloride transmembrane transporter activity
GO:0015116 sulfate transmembrane transporter activity
GO:0015301 anion:anion antiporter activity
GO:0019531 oxalate transmembrane transporter activity
GO:0019532 oxalate transport
GO:0030317 flagellated sperm motility
GO:0048240 sperm capacitation
GO:0051321 meiotic cell cycle

Subcellular Location

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Subcellular Location
Membrane

Domains

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DomainNameCategoryType
IPR001902 SLC26A/SulP transporterFamilyFamily
IPR002645 STAS domainDomainDomain
IPR011547 SLC26A/SulP transporter domainDomainDomain
IPR030303 Solute carrier family 26 member 8 (testis anion transporter 1)FamilyFamily
IPR036513 STAS domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
606766 OMIMSpermatogenic failure 3 (SPGF3)A disorder characterized by primary infertility, sperm morphologic abnormalities, and moderate to severe asthenozoospermia, condition in which the percentage of progressively motile sperm is abnormally low. The disease is caused by variants affecting the gene represented in this entry.

Interactions

3 interactions

InteractorPartnerSourcesPublicationsLink
S26A8_HUMANRGAP1_HUMANBioGRID, HPRD, IntAct11278976 details
S26A8_HUMANCFTR_HUMANUniProt22121115 details
S26A8_HUMANNXF1_HUMANBioGRID7707528 details