Entity Details

Primary name EFGM_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ96RP9
EntryNameEFGM_HUMAN
FullNameElongation factor G, mitochondrial
TaxID9606
Evidenceevidence at protein level
Length751
SequenceStatuscomplete
DateCreated2003-01-27
DateModified2021-06-02

Ontological Relatives

GenesGFM1

GO terms

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GOName
GO:0003723 RNA binding
GO:0003746 translation elongation factor activity
GO:0003924 GTPase activity
GO:0005525 GTP binding
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0070125 mitochondrial translational elongation

Subcellular Location

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Subcellular Location
Mitochondrion

Domains

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DomainNameCategoryType
IPR000640 Elongation factor EFG, domain V-likeDomainDomain
IPR000795 Translational (tr)-type GTP-binding domainDomainDomain
IPR004161 Translation elongation factor EFTu-like, domain 2DomainDomain
IPR004540 Translation elongation factor EFG/EF2FamilyFamily
IPR005225 Small GTP-binding protein domainDomainDomain
IPR005517 Translation elongation factor EFG/EF2, domain IVDomainDomain
IPR009000 Translation protein, beta-barrel domain superfamilyFamilyHomologous superfamily
IPR009022 Elongation factor G, domain IIIDomainDomain
IPR014721 Ribosomal protein S5 domain 2-type fold, subgroupFamilyHomologous superfamily
IPR020568 Ribosomal protein S5 domain 2-type foldFamilyHomologous superfamily
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily
IPR031157 Tr-type G domain, conserved siteSiteConserved site
IPR035647 EF-G domain III/V-likeFamilyHomologous superfamily
IPR035649 EFG, domain VDomainDomain
IPR041095 Elongation Factor G, domain IIDomainDomain

Diseases

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Disease IDSourceNameDescription
609060 OMIMCombined oxidative phosphorylation deficiency 1 (COXPD1)A mitochondrial disease resulting in early rapidly progressive hepatoencephalopathy. The disease is caused by variants affecting the gene represented in this entry.

Interactions

3 interactions

InteractorPartnerSourcesPublicationsLink
EFGM_HUMANTRI63_HUMANBioGRID, MINT18157088 details
EFGM_HUMANTRI55_HUMANBioGRID, MINT18157088 details
EFGM_HUMANSMUF2_HUMANMINT18157088 details