Entity Details

Primary name S22AC_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ96S37
EntryNameS22AC_HUMAN
FullNameSolute carrier family 22 member 12
TaxID9606
Evidenceevidence at protein level
Length553
SequenceStatuscomplete
DateCreated2007-10-23
DateModified2021-06-02

Ontological Relatives

GenesSLC22A12

GO terms

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GOName
GO:0005886 plasma membrane
GO:0015143 urate transmembrane transporter activity
GO:0015711 organic anion transport
GO:0015747 urate transport
GO:0016021 integral component of membrane
GO:0016324 apical plasma membrane
GO:0019725 cellular homeostasis
GO:0030165 PDZ domain binding
GO:0031526 brush border membrane
GO:0042493 response to drug
GO:0046415 urate metabolic process
GO:0070062 extracellular exosome

Subcellular Location

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Subcellular Location
Apical cell membrane
Cell membrane

Domains

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DomainNameCategoryType
IPR005828 Major facilitator, sugar transporter-likeFamilyFamily
IPR020846 Major facilitator superfamily domainDomainDomain
IPR036259 MFS transporter superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
220150 OMIMHypouricemia renal 1 (RHUC1)A disorder characterized by impaired uric acid reabsorption at the apical membrane of proximal renal tubule cells, and high urinary urate excretion. Patients often appear asymptomatic, but may be subject to exercise-induced acute renal failure, chronic renal dysfunction and nephrolithiasis. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB00678 LosartanDrugbanksmall molecule
DB00870 SuprofenDrugbanksmall molecule
DB01032 ProbenecidDrugbanksmall molecule
DB01138 SulfinpyrazoneDrugbanksmall molecule
DB11560 LesinuradDrugbanksmall molecule
DB12466 FavipiravirDrugbanksmall molecule

Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
S22AC_HUMANNHRF3_HUMANBioGRID, HPRD14531806 details