Entity Details

Primary name NOTC4_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ99466
EntryNameNOTC4_HUMAN
FullNameNeurogenic locus notch homolog protein 4
TaxID9606
Evidenceevidence at protein level
Length2003
SequenceStatuscomplete
DateCreated2002-03-27
DateModified2021-06-02

Ontological Relatives

GenesNOTCH4

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000139 Golgi membrane
GO:0001569 branching involved in blood vessel morphogenesis
GO:0001709 cell fate determination
GO:0001763 morphogenesis of a branching structure
GO:0001837 epithelial to mesenchymal transition
GO:0001886 endothelial cell morphogenesis
GO:0001944 vasculature development
GO:0005112 Notch binding
GO:0005509 calcium ion binding
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005789 endoplasmic reticulum membrane
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0007221 positive regulation of transcription of Notch receptor target
GO:0009986 cell surface
GO:0030097 hemopoiesis
GO:0030154 cell differentiation
GO:0030879 mammary gland development
GO:0035278 miRNA mediated inhibition of translation
GO:0038023 signaling receptor activity
GO:0042060 wound healing
GO:0045596 negative regulation of cell differentiation
GO:0045602 negative regulation of endothelial cell differentiation
GO:0045747 positive regulation of Notch signaling pathway
GO:0045893 positive regulation of transcription, DNA-templated
GO:0060354 negative regulation of cell adhesion molecule production
GO:2000048 negative regulation of cell-cell adhesion mediated by cadherin

Subcellular Location

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Subcellular Location
Cell membrane
Nucleus

Domains

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DomainNameCategoryType
IPR000152 EGF-type aspartate/asparagine hydroxylation sitePTMPTM
IPR000742 EGF-like domainDomainDomain
IPR000800 Notch domainDomainDomain
IPR001881 EGF-like calcium-binding domainDomainDomain
IPR002110 Ankyrin repeatRepeatRepeat
IPR008297 NotchFamilyFamily
IPR009030 Growth factor receptor cysteine-rich domain superfamilyFamilyHomologous superfamily
IPR010660 Notch, NOD domainDomainDomain
IPR011656 Notch, NODP domainDomainDomain
IPR013032 EGF-like, conserved siteSiteConserved site
IPR018097 EGF-like calcium-binding, conserved siteSiteConserved site
IPR020683 Ankyrin repeat-containing domainDomainDomain
IPR022355 Neurogenic locus Notch 4FamilyFamily
IPR035993 Notch-like domain superfamilyFamilyHomologous superfamily
IPR036770 Ankyrin repeat-containing domain superfamilyFamilyHomologous superfamily

Diseases

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