Entity Details

Primary name CHP1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ99653
EntryNameCHP1_HUMAN
FullNameCalcineurin B homologous protein 1
TaxID9606
Evidenceevidence at protein level
Length195
SequenceStatuscomplete
DateCreated1998-07-15
DateModified2021-06-02

Ontological Relatives

GenesCHP1

GO terms

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GOName
GO:0000139 Golgi membrane
GO:0001578 microtubule bundle formation
GO:0001933 negative regulation of protein phosphorylation
GO:0004860 protein kinase inhibitor activity
GO:0005509 calcium ion binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005793 endoplasmic reticulum-Golgi intermediate compartment
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005925 focal adhesion
GO:0006469 negative regulation of protein kinase activity
GO:0006611 protein export from nucleus
GO:0006813 potassium ion transport
GO:0006903 vesicle targeting
GO:0006906 vesicle fusion
GO:0007264 small GTPase mediated signal transduction
GO:0008017 microtubule binding
GO:0010923 negative regulation of phosphatase activity
GO:0015459 potassium channel regulator activity
GO:0015630 microtubule cytoskeleton
GO:0019900 kinase binding
GO:0022406 membrane docking
GO:0030133 transport vesicle
GO:0030214 hyaluronan catabolic process
GO:0031122 cytoplasmic microtubule organization
GO:0031397 negative regulation of protein ubiquitination
GO:0031953 negative regulation of protein autophosphorylation
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0032417 positive regulation of sodium:proton antiporter activity
GO:0042308 negative regulation of protein import into nucleus
GO:0048306 calcium-dependent protein binding
GO:0050821 protein stabilization
GO:0051222 positive regulation of protein transport
GO:0051259 protein complex oligomerization
GO:0051453 regulation of intracellular pH
GO:0060050 positive regulation of protein glycosylation
GO:0061024 membrane organization
GO:0061025 membrane fusion
GO:0070062 extracellular exosome
GO:0070885 negative regulation of calcineurin-NFAT signaling cascade
GO:0071073 positive regulation of phospholipid biosynthetic process
GO:0071468 cellular response to acidic pH
GO:0090314 positive regulation of protein targeting to membrane
GO:1901214 regulation of neuron death

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasm
Endomembrane system
Endoplasmic reticulum
Endoplasmic reticulum-Golgi intermediate compartment
Membrane
Nucleus

Domains

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DomainNameCategoryType
IPR002048 EF-hand domainDomainDomain
IPR011992 EF-hand domain pairFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
618438 OMIMSpastic ataxia 9, autosomal recessive (SPAX9)An autosomal recessive disorder characterized by onset of spastic ataxia in the first years of life. Clinical features include motor neuropathy, cerebellar atrophy, spastic paraparesis, intellectual disability, slow ocular saccades, axial hypotonia, distal muscle weakness and atrophy, and pyramidal symptoms, including hyperreflexia and extensor plantar responses. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB11093 Calcium citrateDrugbanksmall molecule
DB11348 Calcium PhosphateDrugbanksmall molecule
DB14481 Calcium phosphate dihydrateDrugbanksmall molecule