Entity Details

Primary name M3K5_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ99683
EntryNameM3K5_HUMAN
FullNameMitogen-activated protein kinase kinase kinase 5
TaxID9606
Evidenceevidence at protein level
Length1374
SequenceStatuscomplete
DateCreated2000-05-30
DateModified2021-06-02

Ontological Relatives

GenesMAP3K5

GO terms

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GOName
GO:0000165 MAPK cascade
GO:0000186 obsolete activation of MAPKK activity
GO:0000287 magnesium ion binding
GO:0002931 response to ischemia
GO:0004672 protein kinase activity
GO:0004709 MAP kinase kinase kinase activity
GO:0005524 ATP binding
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006468 protein phosphorylation
GO:0007254 JNK cascade
GO:0007257 obsolete activation of JUN kinase activity
GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress
GO:0009897 external side of plasma membrane
GO:0010666 positive regulation of cardiac muscle cell apoptotic process
GO:0016032 viral process
GO:0019901 protein kinase binding
GO:0019903 protein phosphatase binding
GO:0019904 protein domain specific binding
GO:0032991 protein-containing complex
GO:0034198 cellular response to amino acid starvation
GO:0034976 response to endoplasmic reticulum stress
GO:0038066 p38MAPK cascade
GO:0042060 wound healing
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0043065 positive regulation of apoptotic process
GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043507 positive regulation of JUN kinase activity
GO:0045087 innate immune response
GO:0045663 positive regulation of myoblast differentiation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0046330 positive regulation of JNK cascade
GO:0051403 stress-activated MAPK cascade
GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0070301 cellular response to hydrogen peroxide
GO:0071356 cellular response to tumor necrosis factor
GO:0072577 endothelial cell apoptotic process
GO:0097190 apoptotic signaling pathway
GO:0097300 programmed necrotic cell death
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:1900745 positive regulation of p38MAPK cascade
GO:1901216 positive regulation of neuron death
GO:1902170 cellular response to reactive nitrogen species
GO:1902911 protein kinase complex
GO:1904707 positive regulation of vascular associated smooth muscle cell proliferation
GO:1990604 IRE1-TRAF2-ASK1 complex

Subcellular Location

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Subcellular Location
Cytoplasm
Endoplasmic reticulum

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR013761 Sterile alpha motif/pointed domain superfamilyFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR025136 MAP3K, TRAFs-binding domainDomainDomain
IPR043969 MAP3K, PH domainDomainDomain

Diseases

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Interactions

129 interactions

InteractorPartnerSourcesPublicationsLink
M3K5_HUMAN1433Z_HUMANBioGRID, HPRD, IntAct, MINT10411906 11336675 15023544 16449798 25852190 29227477 details
M3K5_HUMAN1433S_HUMANHPRD, IntAct15023544 details
M3K5_HUMAN1433B_HUMANIntAct15023544 21771788 details
M3K5_HUMAN1433T_HUMANBioGRID, HPRD, IntAct15023544 17389591 details
M3K5_HUMAN1433F_HUMANHPRD, IntAct, MINT15023544 17700517 28514442 details
M3K5_HUMAN1433E_HUMANBioGRID, HPRD, IntAct15023544 31980649 details
M3K5_HUMANM3K5_HUMANBioGRID, DIP, HPRD, IntAct11336675 11416155 11689443 11920685 12624112 16142216 17541429 17724081 17937911 19805025 20213747 25098452 28205554 31077413 9743501 details
M3K5_HUMANTRAF2_HUMANBioGRID, DIP, HPRD, IntAct10523862 15310755 16636664 17015619 17724081 18776134 19805025 25098452 32445435 9774977 details
M3K5_HUMANAKT1_HUMANBioGRID, HPRD, IntAct11154276 details
M3K5_HUMANM3K6_HUMANBioGRID, HPRD, IntAct11689443 17210579 25852190 9875215 details
M3K5_HUMANARRB2_HUMANBioGRID, HPRD, MINT11090355 11356842 19306926 19782076 details
M3K5_HUMANARRB1_HUMANBioGRID, MINT19306926 19782076 32445435 details
M3K5_HUMANSOCS1_HUMANBioGRID, MINT16407264 18776134 29991678 details
M3K5_HUMANCBP_HUMANBioGRID, IntAct20936779 details
M3K5_HUMANDMD_HUMANBioGRID, IntAct20936779 details
M3K5_HUMANEP300_HUMANBioGRID, IntAct20936779 details
M3K5_HUMANSMN_HUMANBioGRID, MINT21496457 details
M3K5_HUMANTHIO_HUMANBioGRID, DIP, HPRD, IntAct10843682 11689443 12089063 15696199 17331951 17724081 19018770 19805025 20385180 21771788 23291592 25098452 29186683 29227477 9564042 details
M3K5_HUMANZN622_HUMANIntAct21771788 details
M3K5_HUMANMP2K3_HUMANBioGRID, DIP, IntAct16709866 19805025 21771788 28205554 31980649 details
M3K5_HUMANCANB1_HUMANHPRD, MINT16648474 details
M3K5_HUMANTULP3_HUMANBioGRID, IntAct23414517 details
M3K5_HUMANDAB2P_HUMANBioGRID, HPRD, UniProt12813029 15310755 17389591 19903888 24985705 details
M3K5_HUMANCIB1_HUMANBioGRID, DIP19805025 details
M3K5_HUMANCRYA2_HUMANIntAct32814053 details
M3K5_HUMANDYHC1_HUMANIntAct32814053 details
M3K5_HUMANDYN2_HUMANIntAct32814053 details
M3K5_HUMANIF2G_HUMANIntAct32814053 details
M3K5_HUMANGRN_HUMANIntAct32814053 details
M3K5_HUMANHSP72_HUMANIntAct32814053 details
M3K5_HUMANHSPB1_HUMANIntAct32814053 details
M3K5_HUMANVPS29_HUMANIntAct32814053 details
M3K5_HUMANIF2B_HUMANIntAct32814053 details
M3K5_HUMANPRPS1_HUMANIntAct32814053 details
M3K5_HUMANKLK6_HUMANIntAct32814053 details
M3K5_HUMANLRP8_HUMANIntAct32814053 details
M3K5_HUMANKIF1B_HUMANIntAct32814053 details
M3K5_HUMANHTRA2_HUMANIntAct32814053 details
M3K5_HUMANGDAP1_HUMANIntAct32814053 details
M3K5_HUMANHD_HUMANIntAct32814053 details
M3K5_HUMANGA45B_HUMANBioGRID, HPRD14743220 details
M3K5_HUMANPDCD6_HUMANBioGRID, HPRD12372597 details
M3K5_HUMANMPIP1_HUMANBioGRID, HPRD11416155 details
M3K5_HUMANMP2K6_HUMANBioGRID, HPRD11689443 12820963 15866172 16142216 20213747 25098452 details
M3K5_HUMANHS71A_HUMANBioGRID, HPRD12391142 details
M3K5_HUMANHS71B_HUMANBioGRID, HPRD12391142 details
M3K5_HUMANRAF1_HUMANBioGRID, HPRD11427728 28205554 details
M3K5_HUMANJIP3_HUMANBioGRID, HPRD12189133 15258908 details
M3K5_HUMANPPP5_HUMANBioGRID, HPRD11689443 details
M3K5_HUMANM3K7_HUMANBioGRID, HPRD10921914 22167179 details
M3K5_HUMANUSP9X_HUMANBioGRID20005844 details
M3K5_HUMANNEDD4_HUMANBioGRID19953087 details
M3K5_HUMANTNAP3_HUMANBioGRID20448643 29227477 details
M3K5_HUMANNED4L_HUMANBioGRID19953087 details
M3K5_HUMANMP2K4_HUMANBioGRID15258908 15299005 15310755 16142216 17541429 details
M3K5_HUMANJAK2_HUMANBioGRID19287004 details
M3K5_HUMANPTN11_HUMANBioGRID19287004 details
M3K5_HUMANMBP_HUMANBioGRID19293155 details
M3K5_HUMANGEMI5_HUMANBioGRID17541429 details
M3K5_HUMANSIAH1_HUMANBioGRID25391652 details
M3K5_HUMANTPD54_HUMANBioGRID14761963 details
M3K5_HUMANLATS2_HUMANBioGRID28205554 30496488 details
M3K5_HUMANAURKA_HUMANBioGRID28205554 details
M3K5_HUMANCCND2_HUMANBioGRID28205554 details
M3K5_HUMANCDK4_HUMANBioGRID28205554 details
M3K5_HUMANCDK6_HUMANBioGRID28205554 details
M3K5_HUMANCDN2A_HUMANBioGRID28205554 details
M3K5_HUMANARF_HUMANBioGRID28205554 details
M3K5_HUMANFZR1_HUMANBioGRID28205554 details
M3K5_HUMANGLIS2_HUMANBioGRID28205554 details
M3K5_HUMANFGFR4_HUMANBioGRID28205554 details
M3K5_HUMANSTK11_HUMANBioGRID28205554 details
M3K5_HUMANTEAD2_HUMANBioGRID28205554 details
M3K5_HUMANTERT_HUMANBioGRID28205554 details
M3K5_HUMANMERL_HUMANBioGRID28205554 details
M3K5_HUMANSUMO1_HUMANBioGRID16142216 details
M3K5_HUMANUBC9_HUMANBioGRID16142216 details
M3K5_HUMANDAXX_HUMANBioGRID, IntAct, MINT11003656 11495919 15258908 15983381 19789334 25241761 27488634 9743501 details
M3K5_HUMANA4_HUMANBioGRID, IntAct16049941 17719230 25241761 details
M3K5_HUMANGSTP1_HUMANIntAct16636664 details
M3K5_HUMANMP2K7_HUMANBioGRID, HPRD, MINT11959862 17110930 details
M3K5_HUMANTNR6_HUMANBioGRID, IntAct11495919 25241761 details
M3K5_HUMAN1433G_HUMANBioGRID, IntAct, MINT19935702 24985705 28514442 details
M3K5_HUMANMCRS1_HUMANBioGRID, MINT22609355 details
M3K5_HUMANHS90B_HUMANIntAct22939624 details
M3K5_HUMANERN1_HUMANBioGRID, HPRD, IntAct12050113 25241761 25797626 details
M3K5_HUMANPGAM5_HUMANDIP19590015 details
M3K5_HUMANGSTM1_HUMANBioGRID, HPRD, IntAct11278289 12077134 28284893 details
M3K5_HUMANKMT2A_HUMANBioGRID14607843 details
M3K5_HUMANTRAF1_HUMANBioGRID32445435 9774977 details
M3K5_HUMANTRAF3_HUMANBioGRID32445435 9774977 details
M3K5_HUMANTRAF5_HUMANBioGRID, HPRD10523862 32445435 9774977 details
M3K5_HUMANTRAF6_HUMANBioGRID, HPRD10523862 10921914 17724081 31077413 32445435 9774977 details
M3K5_HUMANSYQ_HUMANBioGRID, HPRD11096076 details
M3K5_HUMANDUS19_HUMANBioGRID, HPRD11959862 details
M3K5_HUMANCDN1A_HUMANBioGRID, HPRD12820963 details
M3K5_HUMANRBCC1_HUMANBioGRID17015619 details
M3K5_HUMANE2AK2_HUMANBioGRID, HPRD12473108 details
M3K5_HUMANGLRX1_HUMANBioGRID, HPRD12244106 details
M3K5_HUMANGNA12_HUMANBioGRID17595347 details
M3K5_HUMANGNA13_HUMANBioGRID17595347 details
M3K5_HUMANCHIP_HUMANBioGRID16038411 17595347 20349136 details
M3K5_HUMANALK_HUMANBioGRID14968112 details
M3K5_HUMANSOCS3_HUMANBioGRID16407264 details
M3K5_HUMANHSP74_HUMANBioGRID20349136 details
M3K5_HUMANPRS7_HUMANBioGRID20843792 details
M3K5_HUMANPRS4_HUMANBioGRID20843792 details
M3K5_HUMANPRS6B_HUMANBioGRID20843792 details
M3K5_HUMANPRS6A_HUMANBioGRID20843792 details
M3K5_HUMANPRS8_HUMANBioGRID20843792 details
M3K5_HUMANPARK7_HUMANBioGRID19293155 20213747 details
M3K5_HUMANDYR1A_HUMANBioGRID22110360 details
M3K5_HUMANP85A_HUMANBioGRID19903888 details
M3K5_HUMANTHIOM_HUMANBioGRID23291592 details
M3K5_HUMANG3P_HUMANBioGRID25391652 details
M3K5_HUMANABC3G_HUMANBioGRID25901786 details
M3K5_HUMANFBW1B_HUMANBioGRID30031111 details
M3K5_HUMANFBW1A_HUMANBioGRID30031111 details
M3K5_HUMANCFLAR_HUMANBioGRID29227477 details
M3K5_HUMANAIFM1_HUMANBioGRID29227477 details
M3K5_HUMANAAKG1_HUMANBioGRID29227477 details
M3K5_HUMANTOLIP_HUMANBioGRID31077413 details
M3K5_HUMANTRAF4_HUMANBioGRID32445435 details
M3K5_HUMANTRAF7_HUMANBioGRID32445435 details
M3K5_HUMANTPD53_HUMANHPRD14761963 details
M3K5_HUMANM3K3_HUMANHPRD12912994 details
M3K5_HUMANM3K2_HUMANHPRD12912994 details
M3K5_HUMANTNNT2_HUMANHPRD12819028 details
M3K5_HUMANIGF1R_HUMANHPRD12556535 details