Entity Details

Primary name SMAD7_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO15105
EntryNameSMAD7_HUMAN
FullNameMothers against decapentaplegic homolog 7
TaxID9606
Evidenceevidence at protein level
Length426
SequenceStatuscomplete
DateCreated2001-05-04
DateModified2021-06-02

Ontological Relatives

GenesSMAD7

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000785 chromatin
GO:0001650 fibrillar center
GO:0001657 ureteric bud development
GO:0002725 negative regulation of T cell cytokine production
GO:0003677 DNA binding
GO:0005518 collagen binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0008013 beta-catenin binding
GO:0009653 anatomical structure morphogenesis
GO:0010717 regulation of epithelial to mesenchymal transition
GO:0010719 negative regulation of epithelial to mesenchymal transition
GO:0010801 negative regulation of peptidyl-threonine phosphorylation
GO:0010944 negative regulation of transcription by competitive promoter binding
GO:0016579 protein deubiquitination
GO:0017015 regulation of transforming growth factor beta receptor signaling pathway
GO:0022409 positive regulation of cell-cell adhesion
GO:0030154 cell differentiation
GO:0030279 negative regulation of ossification
GO:0030336 negative regulation of cell migration
GO:0030509 BMP signaling pathway
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway
GO:0030514 negative regulation of BMP signaling pathway
GO:0031397 negative regulation of protein ubiquitination
GO:0031398 positive regulation of protein ubiquitination
GO:0031625 ubiquitin protein ligase binding
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032925 regulation of activin receptor signaling pathway
GO:0032991 protein-containing complex
GO:0033137 negative regulation of peptidyl-serine phosphorylation
GO:0034333 adherens junction assembly
GO:0034616 response to laminar fluid shear stress
GO:0034629 cellular protein-containing complex localization
GO:0034713 type I transforming growth factor beta receptor binding
GO:0043433 negative regulation of DNA-binding transcription factor activity
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046872 metal ion binding
GO:0048185 activin binding
GO:0048844 artery morphogenesis
GO:0050821 protein stabilization
GO:0051444 negative regulation of ubiquitin-protein transferase activity
GO:0055010 ventricular cardiac muscle tissue morphogenesis
GO:0055117 regulation of cardiac muscle contraction
GO:0060373 regulation of ventricular cardiac muscle cell membrane depolarization
GO:0060389 pathway-restricted SMAD protein phosphorylation
GO:0060394 negative regulation of pathway-restricted SMAD protein phosphorylation
GO:0060395 SMAD protein signal transduction
GO:0060412 ventricular septum morphogenesis
GO:0070411 I-SMAD binding
GO:0071144 heteromeric SMAD protein complex
GO:0071560 cellular response to transforming growth factor beta stimulus
GO:0140416 transcription regulator inhibitor activity
GO:1902731 negative regulation of chondrocyte proliferation
GO:1903043 positive regulation of chondrocyte hypertrophy
GO:1990830 cellular response to leukemia inhibitory factor
GO:2000317 negative regulation of T-helper 17 type immune response
GO:2000320 negative regulation of T-helper 17 cell differentiation

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR001132 SMAD domain, Dwarfin-typeDomainDomain
IPR003619 MAD homology 1, Dwarfin-typeDomainDomain
IPR008984 SMAD/FHA domain superfamilyFamilyHomologous superfamily
IPR013019 MAD homology, MH1DomainDomain
IPR013790 DwarfinFamilyFamily
IPR017855 SMAD-like domain superfamilyFamilyHomologous superfamily
IPR036578 SMAD MH1 domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

99 interactions

InteractorPartnerSourcesPublicationsLink
SMAD7_HUMANSMUF2_HUMANBioGRID, DIP, HPRD, MINT11163210 14722617 15221015 15231748 16061177 16641086 17719543 18448069 20937913 22624557 22773947 22921829 23973329 26435193 26679521 27292644 28292929 29235476 32283253 details
SMAD7_HUMANPIAS1_HUMANBioGRID, HPRD, MINT15231748 details
SMAD7_HUMANPIAS4_HUMANBioGRID, HPRD, MINT12815042 15231748 details
SMAD7_HUMANXRCC6_HUMANBioGRID, HPRD, MINT15231748 details
SMAD7_HUMANKDM2A_HUMANBioGRID, HPRD, MINT15231748 details
SMAD7_HUMANHEYL_HUMANBioGRID, HPRD, MINT15231748 details
SMAD7_HUMANCXXC5_HUMANBioGRID, HPRD, MINT15231748 details
SMAD7_HUMANSOX7_HUMANBioGRID, HPRD, MINT15231748 details
SMAD7_HUMANZN107_HUMANBioGRID, HPRD, MINT15231748 details
SMAD7_HUMANTTF2_HUMANBioGRID, HPRD, MINT15231748 details
SMAD7_HUMANMYOD1_HUMANBioGRID, HPRD, MINT15231748 details
SMAD7_HUMANSOX5_HUMANBioGRID, HPRD, MINT15231748 details
SMAD7_HUMANASH1L_HUMANBioGRID, HPRD, MINT15231748 details
SMAD7_HUMANZBT11_HUMANBioGRID, HPRD, MINT15231748 details
SMAD7_HUMANSOX13_HUMANBioGRID, HPRD, MINT15231748 details
SMAD7_HUMANMRTFB_HUMANBioGRID, MINT15231748 details
SMAD7_HUMANTTF1_HUMANBioGRID, HPRD, MINT15231748 details
SMAD7_HUMANCSN5_HUMANBioGRID, IntAct14993265 details
SMAD7_HUMANWWP2_HUMANBioGRID, I2D21258410 22773947 31546607 details
SMAD7_HUMANSIR1_HUMANBioGRID, UniProt17098745 details
SMAD7_HUMANFKB1A_HUMANbhf-ucl, BioGRID16720724 details
SMAD7_HUMANYAP1_HUMANBioGRID, DIP, HPRD, MINT12118366 22921829 25283809 details
SMAD7_HUMANEP300_HUMANBioGRID, HPRD, IntAct12408818 25303530 details
SMAD7_HUMANSMAD4_HUMANBioGRID, IntAct15128733 15817471 17438144 19032343 26555259 details
SMAD7_HUMANSMUF1_HUMANBioGRID, DIP, HPRD11278251 12151385 12519765 14722617 15221015 16720724 20937913 22152476 22773947 22921829 23959799 24700460 27292644 details
SMAD7_HUMANNED4L_HUMANBioGRID, DIP22773947 22921829 details
SMAD7_HUMANTGFR1_HUMANBioGRID, HPRD10757800 11163210 12151385 14657019 14722617 15148321 15359284 15946939 16027725 17314099 19758997 20663871 21791611 22624557 23027871 25149540 31746425 9215638 9335507 details
SMAD7_HUMANRN111_HUMANBioGRID, HPRD14657019 23530056 27292644 details
SMAD7_HUMANDVL1_HUMANBioGRID, HPRD12650946 details
SMAD7_HUMANERBIN_HUMANBioGRID, HPRD12650946 details
SMAD7_HUMANSTABP_HUMANBioGRID, HPRD11483516 details
SMAD7_HUMANSMAD6_HUMANBioGRID, HPRD26555259 9256479 details
SMAD7_HUMANUCHL5_HUMANBioGRID16027725 details
SMAD7_HUMANHDAC1_HUMANBioGRID15831498 15831516 details
SMAD7_HUMANSMAD2_HUMANBioGRID17438144 26555259 details
SMAD7_HUMANZEB1_HUMANBioGRID20514018 details
SMAD7_HUMANUB2L3_HUMANBioGRID16061177 details
SMAD7_HUMANTGFI1_HUMANBioGRID18762808 details
SMAD7_HUMANPR15A_HUMANBioGRID14718519 details
SMAD7_HUMANCBL_HUMANBioGRID26055326 details
SMAD7_HUMANPARD3_HUMANBioGRID, HPRD12650946 details
SMAD7_HUMANAXIN2_HUMANBioGRID24584437 27292644 details
SMAD7_HUMANSMAD3_HUMANBioGRID26555259 details
SMAD7_HUMANSETD7_HUMANBioGRID27292644 details
SMAD7_HUMANOTUD1_HUMANBioGRID29235476 details
SMAD7_HUMANRNF12_HUMANBioGRID29235476 details
SMAD7_HUMANZBT44_HUMANHPRD15231748 details
SMAD7_HUMANMBD1_HUMANHPRD15231748 details
SMAD7_HUMANAXIN1_HUMANBioGRID, HPRD, MINT16601693 18593713 details
SMAD7_HUMANACV1B_HUMANbhf-ucl, BioGRID, HPRD12023024 16720724 20663871 details
SMAD7_HUMANHDAC3_HUMANBioGRID, IntAct15831498 15831516 19032343 details
SMAD7_HUMANRN165_HUMANDIP23610558 details
SMAD7_HUMANBMR1A_HUMANBioGRID15148321 20663871 details
SMAD7_HUMANCTNB1_HUMANBioGRID, HPRD15684397 18593713 details
SMAD7_HUMANLEF1_HUMANBioGRID15684397 15750622 details
SMAD7_HUMANMK14_HUMANBioGRID, HPRD12589052 17172861 details
SMAD7_HUMANMP2K3_HUMANBioGRID12589052 details
SMAD7_HUMANMP2K6_HUMANBioGRID, HPRD12589052 details
SMAD7_HUMANM3K7_HUMANBioGRID, HPRD12589052 details
SMAD7_HUMANTAB1_HUMANBioGRID, HPRD11737269 12589052 details
SMAD7_HUMANTGFR2_HUMANBioGRID, HPRD11163210 25149540 9335507 details
SMAD7_HUMANAKT1_HUMANBioGRID, HPRD16362038 details
SMAD7_HUMANSTRAP_HUMANBioGRID, HPRD10757800 17314099 details
SMAD7_HUMANKAT2B_HUMANBioGRID16285943 details
SMAD7_HUMANITCH_HUMANBioGRID15946939 22773947 28400336 details
SMAD7_HUMANHDAC2_HUMANBioGRID15831498 15831516 details
SMAD7_HUMANHDAC5_HUMANBioGRID15831498 15831516 details
SMAD7_HUMANHDAC6_HUMANBioGRID15831498 15831516 details
SMAD7_HUMANNEDD4_HUMANBioGRID15496141 22773947 details
SMAD7_HUMANSRF_HUMANBioGRID16690609 details
SMAD7_HUMANWWP1_HUMANBioGRID15221015 15359284 22773947 details
SMAD7_HUMANT22D1_HUMANBioGRID21791611 details
SMAD7_HUMANUBP11_HUMANBioGRID22773947 24850914 details
SMAD7_HUMANUBP15_HUMANBioGRID22344298 30980801 details
SMAD7_HUMANTAB2_HUMANBioGRID17384642 details
SMAD7_HUMANTAB3_HUMANBioGRID17384642 details
SMAD7_HUMANTOLIP_HUMANBioGRID23027871 details
SMAD7_HUMANP53_HUMANBioGRID17172861 details
SMAD7_HUMANATM_HUMANBioGRID17172861 details
SMAD7_HUMANBAMBI_HUMANBioGRID19758997 details
SMAD7_HUMANCADH1_HUMANBioGRID18593713 details
SMAD7_HUMANBMPR2_HUMANBioGRID20663871 details
SMAD7_HUMANACVR1_HUMANBioGRID20663871 details
SMAD7_HUMANAVR2B_HUMANBioGRID20663871 details
SMAD7_HUMANUBE2O_HUMANBioGRID23455153 details
SMAD7_HUMANMYC_HUMANBioGRID24259667 details
SMAD7_HUMANSKP2_HUMANBioGRID24259667 details
SMAD7_HUMANTF7L2_HUMANBioGRID15684397 details
SMAD7_HUMANNR4A1_HUMANBioGRID24584437 details
SMAD7_HUMANSMAD1_HUMANBioGRID26555259 details
SMAD7_HUMANSMAD9_HUMANBioGRID26555259 details
SMAD7_HUMANCYLD_HUMANBioGRID30315770 details
SMAD7_HUMANTBR1_HUMANBioGRID30980801 details
SMAD7_HUMANTRI37_HUMANBioGRID32916597 details
SMAD7_HUMANSMAD7_HUMANHPRD12589052 details
SMAD7_HUMANHAT1_HUMANHPRD12408818 details
SMAD7_HUMANSTALP_HUMANHPRD14728725 details
SMAD7_HUMANBMR1B_HUMANHPRD15761153 details
SMAD7_HUMANSASH3_HUMANHPRD15761153 details