Entity Details

Primary name ARC1B_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO15143
EntryNameARC1B_HUMAN
FullNameActin-related protein 2/3 complex subunit 1B
TaxID9606
Evidenceevidence at protein level
Length372
SequenceStatuscomplete
DateCreated1998-07-15
DateModified2021-06-02

Ontological Relatives

GenesARPC1B

GO terms

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GOName
GO:0003779 actin binding
GO:0005200 structural constituent of cytoskeleton
GO:0005634 nucleus
GO:0005829 cytosol
GO:0005885 Arp2/3 protein complex
GO:0005925 focal adhesion
GO:0015629 actin cytoskeleton
GO:0032355 response to estradiol
GO:0034314 Arp2/3 complex-mediated actin nucleation
GO:0036284 tubulobulbar complex
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0043627 response to estrogen
GO:0044877 protein-containing complex binding
GO:0048013 ephrin receptor signaling pathway
GO:0070062 extracellular exosome

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR001680 WD40 repeatRepeatRepeat
IPR015943 WD40/YVTN repeat-like-containing domain superfamilyFamilyHomologous superfamily
IPR017383 Actin-related protein 2/3 complex subunit 1FamilyFamily
IPR030141 Actin-related protein 2/3 complex subunit 1BFamilyFamily
IPR036322 WD40-repeat-containing domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
617718 OMIMPlatelet abnormalities with eosinophilia and immune-mediated inflammatory disease (PLTEID)An autosomal recessive disorder characterized by platelet abnormalities, vasculitis, eosinophilia, and predisposition to inflammatory diseases. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB08235 N-[2-(2-methyl-1H-indol-3-yl)ethyl]thiophene-2-carboxamideDrugbanksmall molecule
DB08236 (2S)-2-(3-bromophenyl)-3-(5-chloro-2-hydroxyphenyl)-1,3-thiazolidin-4-oneDrugbanksmall molecule