Entity Details

Primary name SRBS1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9BX66
EntryNameSRBS1_HUMAN
FullNameSorbin and SH3 domain-containing protein 1
TaxID9606
Evidenceevidence at protein level
Length1292
SequenceStatuscomplete
DateCreated2004-08-31
DateModified2021-06-02

Ontological Relatives

GenesSORBS1

GO terms

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GOName
GO:0001725 stress fiber
GO:0003779 actin binding
GO:0005158 insulin receptor binding
GO:0005634 nucleus
GO:0005813 centrosome
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005912 adherens junction
GO:0005915 zonula adherens
GO:0005925 focal adhesion
GO:0006936 muscle contraction
GO:0007160 cell-matrix adhesion
GO:0008092 cytoskeletal protein binding
GO:0008286 insulin receptor signaling pathway
GO:0016363 nuclear matrix
GO:0030055 cell-substrate junction
GO:0030159 signaling receptor complex adaptor activity
GO:0032869 cellular response to insulin stimulus
GO:0043149 stress fiber assembly
GO:0045121 membrane raft
GO:0045725 positive regulation of glycogen biosynthetic process
GO:0046326 positive regulation of glucose import
GO:0046628 positive regulation of insulin receptor signaling pathway
GO:0046889 positive regulation of lipid biosynthetic process
GO:0048041 focal adhesion assembly
GO:1903078 positive regulation of protein localization to plasma membrane

Subcellular Location

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Subcellular Location
Cell junction
Cell membrane
Cytoplasm
Nucleus
Nucleus matrix

Domains

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DomainNameCategoryType
IPR001452 SH3 domainDomainDomain
IPR003127 SoHo domainDomainDomain
IPR035606 c-Cbl associated protein, SH3 domainDomainDomain
IPR035610 c-Cbl associated protein, SH3 domain 1DomainDomain
IPR035611 c-Cbl associated protein, SH3 domain 2DomainDomain
IPR036028 SH3-like domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

39 interactions

InteractorPartnerSourcesPublicationsLink
SRBS1_HUMANSEM6A_HUMANBioGRID, HPRD, IntAct12421765 details
SRBS1_HUMANABL1_HUMANBioGRID, HPRD, IntAct11374898 19891780 details
SRBS1_HUMANPAK2_HUMANHPRD, MINT16374509 details
SRBS1_HUMANADA15_HUMANHPRD, MINT16374509 details
SRBS1_HUMANSHIP2_HUMANBioGRID, HPRD, IntAct12504111 details
SRBS1_HUMANM4K3_HUMANBioGRID, IntAct20936779 details
SRBS1_HUMANRL4_HUMANBioGRID, IntAct21988832 details
SRBS1_HUMANP3_HUMANBioGRID, IntAct21988832 details
SRBS1_HUMANPILRA_HUMANBioGRID, IntAct21988832 details
SRBS1_HUMANCDK6_HUMANBioGRID, IntAct22094256 details
SRBS1_HUMANABI1_HUMANBioGRID, IntAct23414517 details
SRBS1_HUMANATX7_HUMANMINT23892081 details
SRBS1_HUMANHD_HUMANIntAct17500595 details
SRBS1_HUMANRT4I1_HUMANBioGRID, IntAct32296183 details
SRBS1_HUMANKHDR1_HUMANBioGRID, IntAct22745667 31413325 details
SRBS1_HUMANINSM1_HUMANBioGRID, HPRD12079283 details
SRBS1_HUMANCBL_HUMANBioGRID, HPRD11001060 12504111 15128873 17548467 details
SRBS1_HUMANFLOT1_HUMANBioGRID, HPRD11001060 11481476 15128873 15939299 17548467 details
SRBS1_HUMANAFAD_HUMANBioGRID10085297 34079125 details
SRBS1_HUMANVINC_HUMANBioGRID, HPRD10085297 12765336 17082770 34079125 details
SRBS1_HUMANSRC_HUMANBioGRID19891780 details
SRBS1_HUMANFRS2_HUMANBioGRID22235335 details
SRBS1_HUMANTEN1_HUMANBioGRID15777793 details
SRBS1_HUMANPRGR_HUMANHPRD12650714 details
SRBS1_HUMANINSR_HUMANBioGRID, HPRD, IntAct11374898 details
SRBS1_HUMANDYN2_HUMANMINT19116150 details
SRBS1_HUMANMYC_HUMANIntAct20195357 details
SRBS1_HUMANSMAD2_HUMANIntAct20195357 details
SRBS1_HUMANCASS4_HUMANIntAct31413325 details
SRBS1_HUMANCASP8_HUMANBioGRID12765336 details
SRBS1_HUMANNTRK1_HUMANBioGRID17548467 details
SRBS1_HUMANSH2B2_HUMANBioGRID, HPRD11997497 15031295 17548467 details
SRBS1_HUMANSOS1_HUMANBioGRID17548467 details
SRBS1_HUMANEFNB1_HUMANBioGRID, HPRD11557983 details
SRBS1_HUMANNCK2_HUMANBioGRID11557983 details
SRBS1_HUMANLZTS2_HUMANBioGRID29395067 details
SRBS1_HUMANGRRE1_HUMANBioGRID29395067 details
SRBS1_HUMANPAXI_HUMANBioGRID, HPRD17082770 34079125 details
SRBS1_HUMANACTS_HUMANHPRD17082770 details