Entity Details

Primary name KPCD2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9BZL6
EntryNameKPCD2_HUMAN
FullNameSerine/threonine-protein kinase D2
TaxID9606
Evidenceevidence at protein level
Length878
SequenceStatuscomplete
DateCreated2002-03-27
DateModified2021-06-02

Ontological Relatives

GenesPRKD2

GO terms

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GOName
GO:0001525 angiogenesis
GO:0001938 positive regulation of endothelial cell proliferation
GO:0002250 adaptive immune response
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004698 calcium-dependent protein kinase C activity
GO:0005080 protein kinase C binding
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006468 protein phosphorylation
GO:0007155 cell adhesion
GO:0008219 cell death
GO:0010595 positive regulation of endothelial cell migration
GO:0018105 peptidyl-serine phosphorylation
GO:0018107 peptidyl-threonine phosphorylation
GO:0030148 sphingolipid biosynthetic process
GO:0030949 positive regulation of vascular endothelial growth factor receptor signaling pathway
GO:0032743 positive regulation of interleukin-2 production
GO:0032757 positive regulation of interleukin-8 production
GO:0032793 positive regulation of CREB transcription factor activity
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0035556 intracellular signal transduction
GO:0035924 cellular response to vascular endothelial growth factor stimulus
GO:0038033 positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway
GO:0043536 positive regulation of blood vessel endothelial cell migration
GO:0045743 positive regulation of fibroblast growth factor receptor signaling pathway
GO:0045766 positive regulation of angiogenesis
GO:0045785 positive regulation of cell adhesion
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046777 protein autophosphorylation
GO:0046872 metal ion binding
GO:0048010 vascular endothelial growth factor receptor signaling pathway
GO:0050852 T cell receptor signaling pathway
GO:0050862 positive regulation of T cell receptor signaling pathway
GO:0051091 positive regulation of DNA-binding transcription factor activity
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0061154 endothelial tube morphogenesis
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0089700 protein kinase D signaling
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:1901727 positive regulation of histone deacetylase activity
GO:1902533 positive regulation of intracellular signal transduction
GO:2000573 positive regulation of DNA biosynthetic process
GO:2001028 positive regulation of endothelial cell chemotaxis

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasm
Golgi apparatus
Nucleus

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR001849 Pleckstrin homology domainDomainDomain
IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR011993 PH-like domain superfamilyFamilyHomologous superfamily
IPR015727 Protein kinase C mu-relatedFamilyFamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR020454 Diacylglycerol/phorbol-ester bindingDomainDomain

Diseases

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Interactions

29 interactions

InteractorPartnerSourcesPublicationsLink
KPCD2_HUMANPTN3_HUMANBioGRID, MINT15231748 28675297 details
KPCD2_HUMANMTF2_HUMANBioGRID, MINT15231748 details
KPCD2_HUMANCSKP_HUMANBioGRID, MINT15231748 details
KPCD2_HUMANPDLI7_HUMANBioGRID, MINT15231748 details
KPCD2_HUMANGRIP1_HUMANBioGRID, MINT15231748 details
KPCD2_HUMANRXRA_HUMANBioGRID, MINT15231748 details
KPCD2_HUMANDYST_HUMANBioGRID, MINT15231748 details
KPCD2_HUMANGORS1_HUMANBioGRID, MINT15231748 details
KPCD2_HUMANRARB_HUMANBioGRID, MINT15231748 details
KPCD2_HUMANGLRX3_HUMANBioGRID, MINT15231748 details
KPCD2_HUMANRRBP1_HUMANBioGRID, MINT15231748 details
KPCD2_HUMANRU17_HUMANBioGRID, MINT15231748 details
KPCD2_HUMANHEY1_HUMANBioGRID, MINT15231748 details
KPCD2_HUMANPSG3_HUMANBioGRID, MINT15231748 details
KPCD2_HUMANHDAC7_HUMANBioGRID, HPRD, MINT15623513 17962809 details
KPCD2_HUMANKC1A_HUMANMINT17962809 details
KPCD2_HUMANPFD1_HUMANBioGRID, MINT21900206 details
KPCD2_HUMANARFP1_HUMANMINT23695357 details
KPCD2_HUMANINAR1_HUMANBioGRID21173164 details
KPCD2_HUMANXPO1_HUMANBioGRID, MINT17962809 26673895 details
KPCD2_HUMAN1433F_HUMANIntAct, MINT17962809 28514442 details
KPCD2_HUMANHS90B_HUMANIntAct22939624 details
KPCD2_HUMANSYT2_HUMANMINT22909819 details
KPCD2_HUMANMYH9_HUMANBioGRID, MINT22909819 30652415 details
KPCD2_HUMANHDAC5_HUMANBioGRID21081666 details
KPCD2_HUMANTBG1_HUMANBioGRID30018032 details
KPCD2_HUMANKPCD2_HUMANBioGRID, HPRD11062248 30652415 details
KPCD2_HUMANELAV1_HUMANBioGRID30652415 details
KPCD2_HUMANTGON2_HUMANHPRD14743217 details