Entity Details

Primary name FOXP3_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9BZS1
EntryNameFOXP3_HUMAN
FullNameForkhead box protein P3
TaxID9606
Evidenceevidence at protein level
Length431
SequenceStatuscomplete
DateCreated2001-06-20
DateModified2021-06-02

Ontological Relatives

GenesFOXP3

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000785 chromatin
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:0001782 B cell homeostasis
GO:0001818 negative regulation of cytokine production
GO:0002262 myeloid cell homeostasis
GO:0002362 CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment
GO:0002456 T cell mediated immunity
GO:0002513 tolerance induction to self antigen
GO:0002667 regulation of T cell anergy
GO:0002669 positive regulation of T cell anergy
GO:0002677 negative regulation of chronic inflammatory response
GO:0002725 negative regulation of T cell cytokine production
GO:0002851 positive regulation of peripheral T cell tolerance induction
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0003714 transcription corepressor activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0006338 chromatin remodeling
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription by RNA polymerase II
GO:0008285 negative regulation of cell population proliferation
GO:0009314 response to radiation
GO:0009615 response to virus
GO:0010467 gene expression
GO:0014045 establishment of endothelial blood-brain barrier
GO:0030111 regulation of Wnt signaling pathway
GO:0031064 negative regulation of histone deacetylation
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0032496 response to lipopolysaccharide
GO:0032689 negative regulation of interferon-gamma production
GO:0032693 negative regulation of interleukin-10 production
GO:0032700 negative regulation of interleukin-17 production
GO:0032703 negative regulation of interleukin-2 production
GO:0032713 negative regulation of interleukin-4 production
GO:0032714 negative regulation of interleukin-5 production
GO:0032715 negative regulation of interleukin-6 production
GO:0032720 negative regulation of tumor necrosis factor production
GO:0032753 positive regulation of interleukin-4 production
GO:0032792 negative regulation of CREB transcription factor activity
GO:0032831 positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation
GO:0032914 positive regulation of transforming growth factor beta1 production
GO:0032991 protein-containing complex
GO:0033092 positive regulation of immature T cell proliferation in thymus
GO:0035035 histone acetyltransferase binding
GO:0035066 positive regulation of histone acetylation
GO:0035067 negative regulation of histone acetylation
GO:0042110 T cell activation
GO:0042130 negative regulation of T cell proliferation
GO:0042803 protein homodimerization activity
GO:0042826 histone deacetylase binding
GO:0043029 T cell homeostasis
GO:0043433 negative regulation of DNA-binding transcription factor activity
GO:0043565 sequence-specific DNA binding
GO:0045589 regulation of regulatory T cell differentiation
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046007 negative regulation of activated T cell proliferation
GO:0046872 metal ion binding
GO:0048294 negative regulation of isotype switching to IgE isotypes
GO:0048302 regulation of isotype switching to IgG isotypes
GO:0050687 negative regulation of defense response to virus
GO:0050777 negative regulation of immune response
GO:0050852 T cell receptor signaling pathway
GO:0051059 NF-kappaB binding
GO:0051525 NFAT protein binding
GO:1901355 response to rapamycin
GO:1990837 sequence-specific double-stranded DNA binding
GO:2000320 negative regulation of T-helper 17 cell differentiation

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR001766 Fork head domainDomainDomain
IPR013087 Zinc finger C2H2-typeDomainDomain
IPR030456 Fork head domain conserved site 2SiteConserved site
IPR032354 FOXP, coiled-coil domainDomainDomain
IPR036388 Winged helix-like DNA-binding domain superfamilyFamilyHomologous superfamily
IPR036390 Winged helix DNA-binding domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
304790 OMIMImmunodeficiency polyendocrinopathy, enteropathy, X-linked syndrome (IPEX)Characterized by neonatal onset insulin-dependent diabetes mellitus, infections, secretory diarrhea, thrombocytopenia, anemia and eczema. It is usually lethal in infancy. The disease is caused by variants affecting the gene represented in this entry.

Interactions

40 interactions

InteractorPartnerSourcesPublicationsLink
FOXP3_HUMANPR20C_HUMANBioGRID, IntAct25416956 25910212 29892012 32296183 details
FOXP3_HUMANRBPMS_HUMANBioGRID, IntAct25416956 25910212 29892012 31515488 details
FOXP3_HUMANPIM1_HUMANIntAct25096571 details
FOXP3_HUMANCHIP_HUMANBioGRID, IntAct23973223 33209884 details
FOXP3_HUMANRUNX1_HUMANBioGRID, DIP, HPRD17377532 details
FOXP3_HUMANRORA_HUMANIntAct18354202 details
FOXP3_HUMANPR20D_HUMANBioGRID, IntAct25416956 25910212 29892012 32296183 details
FOXP3_HUMANFOSB_HUMANBioGRID, IntAct32296183 details
FOXP3_HUMANKRA81_HUMANBioGRID, IntAct32296183 details
FOXP3_HUMANKRA33_HUMANBioGRID, IntAct32296183 details
FOXP3_HUMANKRA62_HUMANBioGRID, IntAct32296183 details
FOXP3_HUMANPR20E_HUMANBioGRID, IntAct25416956 25910212 29892012 31515488 32296183 details
FOXP3_HUMANIKZF4_HUMANBioGRID19696312 details
FOXP3_HUMANKAT8_HUMANBioGRID22152480 details
FOXP3_HUMANPR20B_HUMANBioGRID25416956 25910212 29892012 32296183 details
FOXP3_HUMANPR20A_HUMANBioGRID25416956 25910212 29892012 32296183 details
FOXP3_HUMANSIVA_HUMANBioGRID21955384 details
FOXP3_HUMANEP300_HUMANBioGRID16652169 19996091 details
FOXP3_HUMANNLK_HUMANBioGRID30917315 details
FOXP3_HUMANMDM2_HUMANBioGRID32636834 details
FOXP3_HUMANIKZF3_HUMANBioGRID, InnateDB20676092 details
FOXP3_HUMANHDAC2_HUMANBioGRID, MINT19276356 25609649 details
FOXP3_HUMANPP1A_HUMANIntAct23396208 details
FOXP3_HUMANREL_HUMANBioGRID, IntAct20064449 21490927 details
FOXP3_HUMANHDAC1_HUMANBioGRID, IntAct21974802 24944246 details
FOXP3_HUMANNFAC2_HUMANBioGRID, HPRD, IntAct15790681 16517728 19564342 details
FOXP3_HUMANRORG_HUMANDIP18368049 details
FOXP3_HUMANTF65_HUMANBioGRID, IntAct15790681 25712342 details
FOXP3_HUMANZFP90_HUMANIntAct23543754 details
FOXP3_HUMANKAT5_HUMANBioGRID, DIP17360565 19996091 details
FOXP3_HUMANHDAC7_HUMANBioGRID, DIP17360565 details
FOXP3_HUMANHDAC9_HUMANBioGRID, DIP17360565 details
FOXP3_HUMANUBP44_HUMANBioGRID, MINT32644293 details
FOXP3_HUMANHDAC4_HUMANBioGRID19276356 details
FOXP3_HUMANNFAC1_HUMANBioGRID15790681 21490927 details
FOXP3_HUMANH15_HUMANBioGRID21654845 details
FOXP3_HUMANGATA3_HUMANBioGRID23395819 details
FOXP3_HUMANSIR1_HUMANBioGRID19996091 details
FOXP3_HUMANUBP7_HUMANBioGRID30917315 details
FOXP3_HUMANNFAT5_HUMANHPRD15790681 details