Entity Details

Primary name WN10A_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9GZT5
EntryNameWN10A_HUMAN
FullNameProtein Wnt-10a
TaxID9606
Evidenceevidence at protein level
Length417
SequenceStatuscomplete
DateCreated2001-06-20
DateModified2021-06-02

Ontological Relatives

GenesWNT10A

GO terms

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GOName
GO:0001942 hair follicle development
GO:0005109 frizzled binding
GO:0005125 cytokine activity
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0010628 positive regulation of gene expression
GO:0014033 neural crest cell differentiation
GO:0016055 Wnt signaling pathway
GO:0030182 neuron differentiation
GO:0031069 hair follicle morphogenesis
GO:0042476 odontogenesis
GO:0042487 regulation of odontogenesis of dentin-containing tooth
GO:0043586 tongue development
GO:0043588 skin development
GO:0045165 cell fate commitment
GO:0048018 receptor ligand activity
GO:0048730 epidermis morphogenesis
GO:0048733 sebaceous gland development
GO:0060070 canonical Wnt signaling pathway
GO:0071560 cellular response to transforming growth factor beta stimulus

Subcellular Location

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Subcellular Location
Secreted

Domains

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DomainNameCategoryType
IPR005817 WntFamilyFamily
IPR013302 Wnt-10 proteinFamilyFamily
IPR018161 Wnt protein, conserved siteSiteConserved site
IPR043158 Wnt, C-terminal domainFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
224750 OMIMSchopf-Schulz-Passarge syndrome (SSPS)A rare ectodermal dysplasia, characterized chiefly by cysts of the eyelid margins, palmoplantar keratoderma, hypodontia, hypotrichosis and nail dystrophy. Multiple eyelid apocrine hidrocystomas are the hallmark of this condition, although they usually appear in adulthood. The concomitant presence of eccrine syringofibroadenoma in most patients and of other adnexal skin tumors in some affected subjects indicates that Schopf-Schulz-Passarge syndrome is a genodermatosis with skin appendage neoplasms. The disease is caused by variants affecting the gene represented in this entry.
150400 OMIMTooth agenesis, selective, 4 (STHAG4)A form of selective tooth agenesis, a common anomaly characterized by the congenital absence of one or more teeth. Selective tooth agenesis without associated systemic disorders has sometimes been divided into 2 types: oligodontia, defined as agenesis of 6 or more permanent teeth, and hypodontia, defined as agenesis of less than 6 teeth. The number in both cases does not include absence of third molars (wisdom teeth). In STHAG4, the upper lateral incisors are absent or peg-shaped. Some STHAG4 patients manifest mild features of ectodermal dysplasia, including sparse hair, sparse eyebrows, short eyelashes, abnormalities of the nails, sweating anomalies and dry skin. STHAG4 inheritance is autosomal dominant or autosomal recessive. The disease is caused by variants affecting the gene represented in this entry.
257980 OMIMOdonto-onycho-dermal dysplasia (OODD)A rare autosomal recessive ectodermal dysplasia characterized by dry hair, severe hypodontia, smooth tongue with marked reduction of fungiform and filiform papillae, onychodysplasia, keratoderma and hyperhidrosis of palms and soles, and hyperkeratosis of the skin. The disease is caused by variants affecting the gene represented in this entry.

Interactions

1 interaction

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WN10A_HUMANAFAM_HUMANUniProt26902720 details