Entity Details

Primary name HMGB3_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO15347
EntryNameHMGB3_HUMAN
FullNameHigh mobility group protein B3
TaxID9606
Evidenceevidence at protein level
Length200
SequenceStatuscomplete
DateCreated2002-03-27
DateModified2021-06-02

Ontological Relatives

GenesHMGB3

GO terms

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GOName
GO:0000400 four-way junction DNA binding
GO:0003690 double-stranded DNA binding
GO:0003723 RNA binding
GO:0005634 nucleus
GO:0005694 chromosome
GO:0005737 cytoplasm
GO:0006310 DNA recombination
GO:0006357 regulation of transcription by RNA polymerase II
GO:0007275 multicellular organism development
GO:0008301 DNA binding, bending
GO:0032392 DNA geometric change
GO:0045087 innate immune response
GO:0045578 negative regulation of B cell differentiation
GO:0045638 negative regulation of myeloid cell differentiation

Subcellular Location

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Subcellular Location
Chromosome
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR009071 High mobility group box domainDomainDomain
IPR017967 HMG box A DNA-binding domain, conserved siteSiteConserved site
IPR031077 High mobility group protein HMGB3FamilyFamily
IPR036910 High mobility group box domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
300915 OMIMMicrophthalmia, syndromic, 13 (MCOPS13)A form of microphthalmia, a disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues (anophthalmia). In many cases, microphthalmia/anophthalmia occurs in association with syndromes that include non-ocular abnormalities. MCOPS13 patients exhibit colobomatous microphthalmia with microcephaly, short stature, and psychomotor retardation. The disease is caused by variants affecting the gene represented in this entry.

Interactions

7 interactions