Entity Details

Primary name CDT1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9H211
EntryNameCDT1_HUMAN
FullNameDNA replication factor Cdt1
TaxID9606
Evidenceevidence at protein level
Length546
SequenceStatuscomplete
DateCreated2004-12-07
DateModified2021-06-02

Ontological Relatives

GenesCDT1

GO terms

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GOName
GO:0000076 DNA replication checkpoint signaling
GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle
GO:0000278 mitotic cell cycle
GO:0000776 kinetochore
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005829 cytosol
GO:0006270 DNA replication initiation
GO:0007059 chromosome segregation
GO:0016604 nuclear body
GO:0030174 regulation of DNA-dependent DNA replication initiation
GO:0031334 positive regulation of protein-containing complex assembly
GO:0033044 regulation of chromosome organization
GO:0033262 regulation of nuclear cell cycle DNA replication
GO:0035563 positive regulation of chromatin binding
GO:0036388 pre-replicative complex assembly
GO:0045740 positive regulation of DNA replication
GO:0051301 cell division
GO:0051315 attachment of mitotic spindle microtubules to kinetochore
GO:0051383 kinetochore organization
GO:0070182 DNA polymerase binding
GO:0071163 DNA replication preinitiation complex assembly
GO:0072708 response to sorbitol
GO:1902426 deactivation of mitotic spindle assembly checkpoint
GO:1902595 regulation of DNA replication origin binding
GO:1905341 negative regulation of protein localization to kinetochore
GO:1905342 positive regulation of protein localization to kinetochore
GO:2000105 positive regulation of DNA-dependent DNA replication

Subcellular Location

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Subcellular Location
Chromosome
Nucleus

Domains

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DomainNameCategoryType
IPR014939 CDT1 Geminin-binding domain-likeDomainDomain
IPR032054 DNA replication factor Cdt1, C-terminalDomainDomain
IPR036390 Winged helix DNA-binding domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
613804 OMIMMeier-Gorlin syndrome 4 (MGORS4)A syndrome characterized by bilateral microtia, aplasia/hypoplasia of the patellae, and severe intrauterine and postnatal growth retardation with short stature and poor weight gain. Additional clinical findings include anomalies of cranial sutures, microcephaly, apparently low-set and simple ears, microstomia, full lips, highly arched or cleft palate, micrognathia, genitourinary tract anomalies, and various skeletal anomalies. While almost all cases have primordial dwarfism with substantial prenatal and postnatal growth retardation, not all cases have microcephaly, and microtia and absent/hypoplastic patella are absent in some. Despite the presence of microcephaly, intellect is usually normal. The disease is caused by variants affecting the gene represented in this entry.

Interactions

51 interactions

InteractorPartnerSourcesPublicationsLink
CDT1_HUMANGEMI_HUMANBioGRID, DIP, HPRD, IntAct, MINT, UniProt11125146 14578910 14993212 15138268 15232106 15257290 15855168 16482215 17261582 17318181 18162579 18184650 19906994 20980834 21543332 22581055 26496610 27107012 28514442 30018425 31160578 details
CDT1_HUMANORC1_HUMANBioGRID, HPRD, IntAct15232106 details
CDT1_HUMANCDC5L_HUMANBioGRID, HPRD, IntAct15232106 details
CDT1_HUMANCDC6_HUMANBioGRID, HPRD, IntAct14672932 15232106 18162579 25990725 details
CDT1_HUMANORC2_HUMANBioGRID, HPRD, IntAct15232106 details
CDT1_HUMANSKP2_HUMANBioGRID, HPRD, IntAct12840033 14993212 15004027 15855168 18162579 26496610 31160578 details
CDT1_HUMANCDK2_HUMANBioGRID, HPRD, IntAct14993212 15004027 15855168 23455922 26496610 31160578 details
CDT1_HUMANCCNA2_HUMANBioGRID, HPRD, IntAct14993212 18184650 26186194 26496610 28514442 31160578 details
CDT1_HUMANCDK1_HUMANBioGRID, HPRD, IntAct14993212 26186194 28514442 31160578 details
CDT1_HUMANPCNA_HUMANBioGRID, HPRD, MINT16362051 16407242 16407252 16482215 16861906 18162579 21930785 24423875 26272819 30018425 30301766 30623174 details
CDT1_HUMANMCM6_HUMANBioGRID, HPRD, IntAct, UniProt12192004 18162579 18184650 20202939 21099365 22140117 26496610 details
CDT1_HUMANNDC80_HUMANDIP22581055 details
CDT1_HUMANCDC23_HUMANBioGRID18162579 details
CDT1_HUMANSMCA5_HUMANBioGRID18162579 21937426 details
CDT1_HUMANBAZ1B_HUMANBioGRID18162579 details
CDT1_HUMANMCM4_HUMANBioGRID18162579 details
CDT1_HUMANGRWD1_HUMANBioGRID18162579 25990725 details
CDT1_HUMANNPM_HUMANBioGRID18162579 details
CDT1_HUMANTOP1_HUMANBioGRID18162579 details
CDT1_HUMANAPC7_HUMANBioGRID18162579 details
CDT1_HUMANTOP2A_HUMANBioGRID18162579 details
CDT1_HUMANCDC20_HUMANBioGRID18162579 details
CDT1_HUMANFZR1_HUMANBioGRID18162579 details
CDT1_HUMANHDA11_HUMANBioGRID19276081 20980834 details
CDT1_HUMANKAT2B_HUMANBioGRID19276081 details
CDT1_HUMANEP300_HUMANBioGRID19276081 details
CDT1_HUMANKAT7_HUMANBioGRID18832067 20980834 details
CDT1_HUMANDDB1_HUMANBioGRID15448697 22451935 details
CDT1_HUMANFOXO3_HUMANBioGRID22451935 details
CDT1_HUMANCCNB1_HUMANBioGRID14993212 details
CDT1_HUMANDTL_HUMANBioGRID21930785 24906324 26272819 30623174 details
CDT1_HUMANFBX31_HUMANBioGRID24828503 details
CDT1_HUMANMK14_HUMANBioGRID21930785 details
CDT1_HUMANMCM2_HUMANBioGRID21930785 details
CDT1_HUMANCCNA1_HUMANBioGRID, IntAct14993212 15004027 15138268 31160578 details
CDT1_HUMANCUL1_HUMANBioGRID12840033 30018425 details
CDT1_HUMANAPC5_HUMANBioGRID18162579 details
CDT1_HUMANIMA1_HUMANBioGRID18162579 details
CDT1_HUMANIMB1_HUMANBioGRID18162579 details
CDT1_HUMANDDB2_HUMANBioGRID15448697 details
CDT1_HUMANCUL4A_HUMANBioGRID14578910 15448697 17079684 details
CDT1_HUMANCCNE1_HUMANBioGRID15004027 details
CDT1_HUMANCDK4_HUMANBioGRID15004027 details
CDT1_HUMANCUL4B_HUMANBioGRID14578910 details
CDT1_HUMANCSN5_HUMANBioGRID17079684 details
CDT1_HUMANMK09_HUMANBioGRID21930785 details
CDT1_HUMANFAF1_HUMANBioGRID26842564 details
CDT1_HUMANUBP37_HUMANBioGRID27296872 details
CDT1_HUMANMCM7_HUMANBioGRID25990725 details
CDT1_HUMANCDT1_HUMANBioGRID, HPRD14993212 31160578 details
CDT1_HUMANUBB_HUMANHPRD16407252 details