Entity Details

Primary name TARA_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9H2D6
EntryNameTARA_HUMAN
FullNameTRIO and F-actin-binding protein
TaxID9606
Evidenceevidence at protein level
Length2365
SequenceStatuscomplete
DateCreated2002-05-02
DateModified2021-06-02

Ontological Relatives

GenesTRIOBP

GO terms

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GOName
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005815 microtubule organizing center
GO:0005925 focal adhesion
GO:0007015 actin filament organization
GO:0007049 cell cycle
GO:0007605 sensory perception of sound
GO:0015629 actin cytoskeleton
GO:0030047 actin modification
GO:0030496 midbody
GO:0031267 small GTPase binding
GO:0031625 ubiquitin protein ligase binding
GO:0045159 myosin II binding
GO:0051015 actin filament binding
GO:0051016 barbed-end actin filament capping
GO:0051301 cell division
GO:0060088 auditory receptor cell stereocilium organization
GO:0120044 stereocilium base
GO:1900026 positive regulation of substrate adhesion-dependent cell spreading

Subcellular Location

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Subcellular Location
Cytoplasm
Midbody
Nucleus

Domains

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DomainNameCategoryType
IPR001849 Pleckstrin homology domainDomainDomain
IPR011993 PH-like domain superfamilyFamilyHomologous superfamily
IPR039597 Myosin phosphatase-RhoA interacting protein, PH domainDomainDomain

Diseases

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Disease IDSourceNameDescription
609823 OMIMDeafness, autosomal recessive, 28 (DFNB28)A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. The disease is caused by variants affecting the gene represented in this entry.