Entity Details

Primary name SMOC2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9H3U7
EntryNameSMOC2_HUMAN
FullNameSPARC-related modular calcium-binding protein 2
TaxID9606
Evidenceevidence at protein level
Length446
SequenceStatuscomplete
DateCreated2003-10-31
DateModified2021-06-02

Ontological Relatives

GenesSMOC2

GO terms

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GOName
GO:0005509 calcium ion binding
GO:0005604 basement membrane
GO:0005615 extracellular space
GO:0008201 heparin binding
GO:0010595 positive regulation of endothelial cell migration
GO:0030198 extracellular matrix organization
GO:0035470 positive regulation of vascular wound healing
GO:0045743 positive regulation of fibroblast growth factor receptor signaling pathway
GO:0045766 positive regulation of angiogenesis
GO:0045931 positive regulation of mitotic cell cycle
GO:0050840 extracellular matrix binding
GO:0071944 cell periphery
GO:1900748 positive regulation of vascular endothelial growth factor signaling pathway
GO:2000573 positive regulation of DNA biosynthetic process
GO:2001028 positive regulation of endothelial cell chemotaxis

Subcellular Location

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Subcellular Location
Secreted

Domains

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DomainNameCategoryType
IPR000716 Thyroglobulin type-1DomainDomain
IPR002048 EF-hand domainDomainDomain
IPR002350 Kazal domainDomainDomain
IPR011992 EF-hand domain pairFamilyHomologous superfamily
IPR018247 EF-Hand 1, calcium-binding siteSiteBinding site
IPR019577 SPARC/Testican, calcium-binding domainDomainDomain
IPR036058 Kazal domain superfamilyFamilyHomologous superfamily
IPR036857 Thyroglobulin type-1 superfamilyFamilyHomologous superfamily
IPR037640 SMOC-2, extracellular calcium-binding domainDomainDomain

Diseases

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Disease IDSourceNameDescription
125400 OMIMDentin dysplasia 1 (DTDP1)A dental defect in which both primary and secondary dentitions are affected. The clinical crowns of both permanent and deciduous teeth are of normal shape, form and color in most cases, although they may be slightly opalescent and blue or brown. Teeth may be very mobile and exfoliate spontaneously because of inadequate root formation. On radiographs, the roots are short and may be more pointed than normal. Pulp chambers are usually absent except for a chevron-shaped remnant in the crown. Root canals are usually absent. The disease is caused by variants affecting the gene represented in this entry.

Interactions

4 interactions