Entity Details

Primary name TLE6_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9H808
EntryNameTLE6_HUMAN
FullNameTransducin-like enhancer protein 6
TaxID9606
Evidenceevidence at protein level
Length572
SequenceStatuscomplete
DateCreated2005-04-26
DateModified2021-06-02

Ontological Relatives

GenesTLE6

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0003714 transcription corepressor activity
GO:0005634 nucleus
GO:0005667 transcription regulator complex
GO:0005737 cytoplasm
GO:0005938 cell cortex
GO:0007015 actin filament organization
GO:0032991 protein-containing complex
GO:0040019 positive regulation of embryonic development
GO:0051293 establishment of spindle localization
GO:0051302 regulation of cell division
GO:0051643 endoplasmic reticulum localization
GO:0051646 mitochondrion localization
GO:0060136 embryonic process involved in female pregnancy
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0106333 subcortical maternal complex

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR001680 WD40 repeatRepeatRepeat
IPR009146 Groucho/transducin-like enhancerFamilyFamily
IPR015943 WD40/YVTN repeat-like-containing domain superfamilyFamilyHomologous superfamily
IPR036322 WD40-repeat-containing domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
616814 OMIMPreimplantation embryonic lethality 1 (PREMBL1)A rare cause of female primary infertility. In affected women, ovulation proceeds normally and the retrieved oocytes appear normal, but zygote formation and division are severely impaired. Inheritance is autosomal recessive. The disease is caused by variants affecting the gene represented in this entry.