Entity Details

Primary name UD18_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9HAW9
EntryNameUD18_HUMAN
FullNameUDP-glucuronosyltransferase 1A8
TaxID9606
Evidenceevidence at protein level
Length530
SequenceStatuscomplete
DateCreated2003-04-11
DateModified2021-06-02

Ontological Relatives

GenesUGT1A8

GO terms

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GOName
GO:0001972 retinoic acid binding
GO:0004857 enzyme inhibitor activity
GO:0005496 steroid binding
GO:0005504 fatty acid binding
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0006631 fatty acid metabolic process
GO:0008144 drug binding
GO:0008202 steroid metabolic process
GO:0009804 coumarin metabolic process
GO:0015020 glucuronosyltransferase activity
GO:0016021 integral component of membrane
GO:0017144 drug metabolic process
GO:0019899 enzyme binding
GO:0042573 retinoic acid metabolic process
GO:0042803 protein homodimerization activity
GO:0045922 negative regulation of fatty acid metabolic process
GO:0045939 negative regulation of steroid metabolic process
GO:0046982 protein heterodimerization activity
GO:0051552 flavone metabolic process
GO:0052695 cellular glucuronidation
GO:0052696 flavonoid glucuronidation
GO:0052697 xenobiotic glucuronidation
GO:1904224 negative regulation of glucuronosyltransferase activity
GO:2001030 negative regulation of cellular glucuronidation

Subcellular Location

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Subcellular Location
Endoplasmic reticulum membrane

Domains

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DomainNameCategoryType
IPR002213 UDP-glucuronosyl/UDP-glucosyltransferaseFamilyFamily
IPR035595 UDP-glycosyltransferase family, conserved siteDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB00197 TroglitazoneDrugbanksmall molecule
DB00295 MorphineDrugbanksmall molecule
DB00313 Valproic acidDrugbanksmall molecule
DB00481 RaloxifeneDrugbanksmall molecule
DB00503 RitonavirDrugbanksmall molecule
DB00555 LamotrigineDrugbanksmall molecule
DB00688 Mycophenolate mofetilDrugbanksmall molecule
DB00714 ApomorphineDrugbanksmall molecule
DB00783 EstradiolDrugbanksmall molecule
DB00788 NaproxenDrugbanksmall molecule
DB00794 PrimidoneDrugbanksmall molecule
DB00818 PropofolDrugbanksmall molecule
DB00861 DiflunisalDrugbanksmall molecule
DB00983 FormoterolDrugbanksmall molecule
DB06230 NalmefeneDrugbanksmall molecule
DB06401 BazedoxifeneDrugbanksmall molecule
DB09038 EmpagliflozinDrugbanksmall molecule
DB09079 NintedanibDrugbanksmall molecule
DB11633 IsavuconazoleDrugbanksmall molecule
DB11796 FostemsavirDrugbanksmall molecule
DB14635 Curcumin sulfateDrugbanksmall molecule