Entity Details

Primary name TF7L2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9NQB0
EntryNameTF7L2_HUMAN
FullNameTranscription factor 7-like 2
TaxID9606
Evidenceevidence at protein level
Length619
SequenceStatuscomplete
DateCreated2003-03-25
DateModified2021-06-02

Ontological Relatives

GenesTCF7L2

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000785 chromatin
GO:0000976 transcription cis-regulatory region binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001568 blood vessel development
GO:0003700 DNA-binding transcription factor activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0006357 regulation of transcription by RNA polymerase II
GO:0007223 Wnt signaling pathway, calcium modulating pathway
GO:0008013 beta-catenin binding
GO:0008134 transcription factor binding
GO:0009749 response to glucose
GO:0010909 positive regulation of heparan sulfate proteoglycan biosynthetic process
GO:0016605 PML body
GO:0019901 protein kinase binding
GO:0031016 pancreas development
GO:0032024 positive regulation of insulin secretion
GO:0032092 positive regulation of protein binding
GO:0032350 regulation of hormone metabolic process
GO:0032993 protein-DNA complex
GO:0042593 glucose homeostasis
GO:0043433 negative regulation of DNA-binding transcription factor activity
GO:0043565 sequence-specific DNA binding
GO:0043570 maintenance of DNA repeat elements
GO:0044334 canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition
GO:0045295 gamma-catenin binding
GO:0045444 fat cell differentiation
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046827 positive regulation of protein export from nucleus
GO:0048625 myoblast fate commitment
GO:0048660 regulation of smooth muscle cell proliferation
GO:0050679 positive regulation of epithelial cell proliferation
GO:0051897 positive regulation of protein kinase B signaling
GO:0060070 canonical Wnt signaling pathway
GO:0060260 regulation of transcription initiation from RNA polymerase II promoter
GO:0070016 armadillo repeat domain binding
GO:0070369 beta-catenin-TCF7L2 complex
GO:0071664 catenin-TCF7L2 complex
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:1904837 beta-catenin-TCF complex assembly
GO:1990907 beta-catenin-TCF complex
GO:2000675 negative regulation of type B pancreatic cell apoptotic process
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR009071 High mobility group box domainDomainDomain
IPR013558 CTNNB1 binding, N-teminalDomainDomain
IPR024940 Transcription factor TCF/LEFFamilyFamily
IPR027397 Catenin binding domain superfamilyFamilyHomologous superfamily
IPR036910 High mobility group box domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
125853 OMIMDiabetes mellitus, non-insulin-dependent (NIDDM)A multifactorial disorder of glucose homeostasis caused by a lack of sensitivity to the body's own insulin. Affected individuals usually have an obese body habitus and manifestations of a metabolic syndrome characterized by diabetes, insulin resistance, hypertension and hypertriglyceridemia. The disease results in long-term complications that affect the eyes, kidneys, nerves, and blood vessels. Disease susceptibility is associated with variants affecting the gene represented in this entry.

Interactions

69 interactions

InteractorPartnerSourcesPublicationsLink
TF7L2_HUMANCTNB1_HUMANBioGRID, DIP, IntAct, MINT, Molecular Connections11713475 11713476 16230076 16442529 16569639 16630820 16724116 17050667 17283121 17914096 18772112 19202075 19304756 19443654 19816403 20126258 21670201 22014570 22056988 22155184 22304967 26350900 27684187 27902311 29540185 30833792 30918250 34079125 details
TF7L2_HUMANDAXX_HUMANBioGRID, IntAct16569639 19563778 details
TF7L2_HUMANHIC1_HUMANBioGRID, MINT16724116 details
TF7L2_HUMANTNIK_HUMANMINT19816403 details
TF7L2_HUMANFBLN1_HUMANBioGRID, IntAct21988832 details
TF7L2_HUMANPSA3_HUMANBioGRID, IntAct21988832 details
TF7L2_HUMANUBC9_HUMANBioGRID, IntAct21988832 23395904 details
TF7L2_HUMANRBPMS_HUMANBioGRID, IntAct27107012 details
TF7L2_HUMANKCNE4_HUMANBioGRID, IntAct27107012 details
TF7L2_HUMANCRTP1_HUMANBioGRID, IntAct32296183 details
TF7L2_HUMANTRAF1_HUMANBioGRID, IntAct32296183 details
TF7L2_HUMANTLE5_HUMANBioGRID, IntAct32296183 details
TF7L2_HUMANPR20D_HUMANBioGRID, IntAct32296183 details
TF7L2_HUMANPLAK_HUMANBioGRID, IntAct11711551 32296183 details
TF7L2_HUMANGOGA2_HUMANIntAct32296183 details
TF7L2_HUMANSMUG1_HUMANBioGRID, IntAct32296183 details
TF7L2_HUMANPKHB1_HUMANIntAct32296183 details
TF7L2_HUMANUFSP1_HUMANBioGRID, IntAct32296183 details
TF7L2_HUMANINT11_HUMANBioGRID, IntAct32296183 details
TF7L2_HUMANKRA62_HUMANBioGRID, IntAct32296183 details
TF7L2_HUMANCS054_HUMANBioGRID, IntAct32296183 details
TF7L2_HUMANAAKB2_HUMANBioGRID, IntAct32296183 details
TF7L2_HUMANMSX2_HUMANBioGRID, IntAct32296183 details
TF7L2_HUMANKR197_HUMANBioGRID, IntAct32296183 details
TF7L2_HUMANKRA71_HUMANBioGRID, IntAct32296183 details
TF7L2_HUMANKRA61_HUMANBioGRID, IntAct32296183 details
TF7L2_HUMANCRX_HUMANBioGRID, IntAct32296183 details
TF7L2_HUMANKR195_HUMANBioGRID, IntAct32296183 details
TF7L2_HUMANCNFN_HUMANBioGRID, IntAct32296183 details
TF7L2_HUMANBPIA1_HUMANBioGRID, IntAct32296183 details
TF7L2_HUMANF168B_HUMANBioGRID, IntAct32296183 details
TF7L2_HUMANKR212_HUMANBioGRID, IntAct32296183 details
TF7L2_HUMANDAZP2_HUMANBioGRID19304756 details
TF7L2_HUMANCTBP1_HUMANBioGRID12711682 26350900 details
TF7L2_HUMANMD2L2_HUMANBioGRID19443654 details
TF7L2_HUMANKAISO_HUMANBioGRID21670201 details
TF7L2_HUMANMEN1_HUMANBioGRID19074834 details
TF7L2_HUMANUBP4_HUMANBioGRID20141612 details
TF7L2_HUMANANDR_HUMANBioGRID12799378 details
TF7L2_HUMANRN138_HUMANBioGRID16714285 details
TF7L2_HUMANKMT5A_HUMANBioGRID21282610 details
TF7L2_HUMANTLE3_HUMANBioGRID22304967 details
TF7L2_HUMANXIAP_HUMANBioGRID22304967 details
TF7L2_HUMANCCNG2_HUMANBioGRID27107012 details
TF7L2_HUMANTSC1_HUMANBioGRID32296183 details
TF7L2_HUMANZNF34_HUMANBioGRID32296183 details
TF7L2_HUMANPR20E_HUMANBioGRID32296183 details
TF7L2_HUMANPR20C_HUMANBioGRID32296183 details
TF7L2_HUMANPR20B_HUMANBioGRID32296183 details
TF7L2_HUMANPR20A_HUMANBioGRID32296183 details
TF7L2_HUMANXRCC6_HUMANBioGRID, IntAct17283121 27684187 30833792 details
TF7L2_HUMANRUNX3_HUMANIntAct18772112 details
TF7L2_HUMANJERKY_HUMANMINT21399610 details
TF7L2_HUMANFOXM1_HUMANIntAct22014570 details
TF7L2_HUMANLEF1_HUMANBioGRID, IntAct22014570 24748645 details
TF7L2_HUMANNLK_HUMANBioGRID12556497 details
TF7L2_HUMANPSN1_HUMANBioGRID11504726 details
TF7L2_HUMANPML_HUMANBioGRID22155184 details
TF7L2_HUMANHBP1_HUMANBioGRID11500377 details
TF7L2_HUMANFUS_HUMANBioGRID16230076 details
TF7L2_HUMANCDC73_HUMANBioGRID16630820 details
TF7L2_HUMANEP300_HUMANBioGRID17050667 details
TF7L2_HUMANSMAD7_HUMANBioGRID15684397 details
TF7L2_HUMANRNF43_HUMANBioGRID26350900 32103169 details
TF7L2_HUMANUBR5_HUMANBioGRID28689657 details
TF7L2_HUMANFOXA2_HUMANBioGRID22951069 details
TF7L2_HUMANHNF4A_HUMANBioGRID22951069 details
TF7L2_HUMANGATA3_HUMANBioGRID22951069 details
TF7L2_HUMANALG13_HUMANBioGRID29395067 details