Entity Details

Primary name DAZ3_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9NR90
EntryNameDAZ3_HUMAN
FullNameDeleted in azoospermia protein 3
TaxID9606
Evidenceevidence at protein level
Length486
SequenceStatuscomplete
DateCreated2004-03-01
DateModified2021-06-02

Ontological Relatives

GenesDAZ3

GO terms

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GOName
GO:0003730 mRNA 3'-UTR binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0007275 multicellular organism development
GO:0007283 spermatogenesis
GO:0008494 translation activator activity
GO:0030154 cell differentiation
GO:0032991 protein-containing complex
GO:0045948 positive regulation of translational initiation
GO:0070935 3'-UTR-mediated mRNA stabilization

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000504 RNA recognition motif domainDomainDomain
IPR012677 Nucleotide-binding alpha-beta plait domain superfamilyFamilyHomologous superfamily
IPR034778 Deleted in azoospermia protein 1-4FamilyFamily
IPR035979 RNA-binding domain superfamilyFamilyHomologous superfamily
IPR037366 BOULE/DAZ familyFamilyFamily
IPR037551 DAZ, RNA recognition motif, vertebratesDomainDomain
IPR043628 DAZ domainDomainDomain

Diseases

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Disease IDSourceNameDescription
415000 OMIMSpermatogenic failure Y-linked 2 (SPGFY2)A disorder resulting in the absence (azoospermia) or reduction (oligozoospermia) of sperm in the semen, leading to male infertility. The disease may be caused by variants affecting the gene represented in this entry. AZFc deletions in the Yq11.23 region including the DAZ genes are the most common known genetic cause of human male infertility.