Entity Details

Primary name PLPL3_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9NST1
EntryNamePLPL3_HUMAN
FullName1-acylglycerol-3-phosphate O-acyltransferase PNPLA3
TaxID9606
Evidenceevidence at protein level
Length481
SequenceStatuscomplete
DateCreated2003-07-03
DateModified2021-06-02

Ontological Relatives

GenesPNPLA3

GO terms

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GOName
GO:0001676 long-chain fatty acid metabolic process
GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity
GO:0004623 phospholipase A2 activity
GO:0004806 triglyceride lipase activity
GO:0005737 cytoplasm
GO:0005789 endoplasmic reticulum membrane
GO:0005811 lipid droplet
GO:0006650 glycerophospholipid metabolic process
GO:0006654 phosphatidic acid biosynthetic process
GO:0009744 response to sucrose
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0019432 triglyceride biosynthetic process
GO:0019433 triglyceride catabolic process
GO:0032869 cellular response to insulin stimulus
GO:0034389 lipid droplet organization
GO:0035727 lysophosphatidic acid binding
GO:0036042 long-chain fatty acyl-CoA binding
GO:0036153 triglyceride acyl-chain remodeling
GO:0036155 acylglycerol acyl-chain remodeling
GO:0042171 lysophosphatidic acid acyltransferase activity
GO:0050872 white fat cell differentiation
GO:0051264 mono-olein transacylation activity
GO:0051265 diolein transacylation activity
GO:0055088 lipid homeostasis
GO:1905243 cellular response to 3,3',5-triiodo-L-thyronine

Subcellular Location

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Subcellular Location
Lipid droplet
Membrane

Domains

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DomainNameCategoryType
IPR002641 Patatin-like phospholipase domainDomainDomain
IPR016035 Acyl transferase/acyl hydrolase/lysophospholipaseFamilyHomologous superfamily
IPR033562 Patatin-like phospholipase domain-containing proteinFamilyFamily
IPR039185 1-acylglycerol-3-phosphate O-acyltransferase PNPLA3FamilyFamily

Diseases

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Disease IDSourceNameDescription
613282 OMIMNon-alcoholic fatty liver disease 1 (NAFLD1)A condition characterized by accumulation of triglycerides in the liver. It is associated with adverse metabolic consequences, including insulin resistance and dyslipidemia. In a subset of individuals, hepatic steatosis promotes an inflammatory response in the liver, referred to as steatohepatitis, which can progress to cirrhosis and liver cancer. NAFLD is the most common form of liver disease in Western countries. Disease susceptibility is associated with variants affecting the gene represented in this entry.

Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
PLPL3_HUMANAKT2_HUMANBioGRID, IntAct21988832 details
PLPL3_HUMANSNX27_HUMANBioGRID, IntAct21988832 details