Entity Details

Primary name SPIT2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO43291
EntryNameSPIT2_HUMAN
FullNameKunitz-type protease inhibitor 2
TaxID9606
Evidenceevidence at protein level
Length252
SequenceStatuscomplete
DateCreated2001-02-21
DateModified2021-06-02

Ontological Relatives

GenesSPINT2

GO terms

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GOName
GO:0001843 neural tube closure
GO:0004866 endopeptidase inhibitor activity
GO:0004867 serine-type endopeptidase inhibitor activity
GO:0005576 extracellular region
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0007163 establishment or maintenance of cell polarity
GO:0016021 integral component of membrane
GO:0022408 negative regulation of cell-cell adhesion
GO:0060672 epithelial cell morphogenesis involved in placental branching
GO:0071711 basement membrane organization
GO:0071773 cellular response to BMP stimulus
GO:2000146 negative regulation of cell motility
GO:2000178 negative regulation of neural precursor cell proliferation

Subcellular Location

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Subcellular Location
Membrane

Domains

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DomainNameCategoryType
IPR002223 Pancreatic trypsin inhibitor Kunitz domainDomainDomain
IPR020901 Proteinase inhibitor I2, Kunitz, conserved siteSiteConserved site
IPR036880 Pancreatic trypsin inhibitor Kunitz domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
270420 OMIMDiarrhea 3, secretory sodium, congenital, with or without other congenital anomalies (DIAR3)A disease characterized by life-threatening secretory diarrhea, severe metabolic acidosis and hyponatremia. Hyponatremia is secondary to extraordinarily high fecal sodium loss, with low or normal excretion of urinary sodium, in the absence of infectious, autoimmune and endocrine causes. The disease is caused by variants affecting the gene represented in this entry.