Entity Details

Primary name MED17_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9NVC6
EntryNameMED17_HUMAN
FullNameMediator of RNA polymerase II transcription subunit 17
TaxID9606
Evidenceevidence at protein level
Length651
SequenceStatuscomplete
DateCreated2003-02-28
DateModified2021-06-02

Ontological Relatives

GenesMED17

GO terms

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GOName
GO:0003712 transcription coregulator activity
GO:0003713 transcription coactivator activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005667 transcription regulator complex
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0016020 membrane
GO:0016592 mediator complex
GO:0030374 nuclear receptor coactivator activity
GO:0042809 vitamin D receptor binding
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046966 thyroid hormone receptor binding
GO:0060260 regulation of transcription initiation from RNA polymerase II promoter
GO:0060261 positive regulation of transcription initiation from RNA polymerase II promoter
GO:0070847 core mediator complex

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR019313 Mediator complex, subunit Med17FamilyFamily

Diseases

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Disease IDSourceNameDescription
613668 OMIMMicrocephaly, postnatal progressive, with seizures and brain atrophy (MCPHSBA)A disorder characterized by postnatal progressive microcephaly and severe developmental retardation associated with cerebral and cerebellar atrophy. Infants manifest swallowing difficulties leading to failure to thrive, jitteriness, poor visual fixation, truncal arching, seizures. There is no acquisition of developmental milestones and patients suffer from marked spasticity and profound retardation. Progressive microcephaly becomes evident few months after birth. The disease is caused by variants affecting the gene represented in this entry.

Interactions

43 interactions

InteractorPartnerSourcesPublicationsLink
MED17_HUMANMED19_HUMANBioGRID, HPRD, IntAct12584197 14576168 14638676 15175163 21729782 24981860 26186194 26344197 28514442 details
MED17_HUMANMED29_HUMANBioGRID, IntAct14576168 14638676 15175163 15989967 24981860 26344197 details
MED17_HUMANESR1_HUMANBioGRID, IntAct11867769 21182203 details
MED17_HUMANESR2_HUMANBioGRID, IntAct11867769 21182203 29509190 details
MED17_HUMANMED18_HUMANBioGRID, IntAct, MINT15989967 20133760 24882805 24981860 26344197 28514442 details
MED17_HUMANMED28_HUMANBioGRID, IntAct, MINT15175163 15989967 20133760 22939629 24882805 24981860 details
MED17_HUMANPRGC1_HUMANBioGRID14636573 details
MED17_HUMANSMCA4_HUMANBioGRID12154023 22668559 details
MED17_HUMANP53_HUMANBioGRID, HPRD10198638 details
MED17_HUMANHNF4A_HUMANBioGRID12101254 details
MED17_HUMANSRBP1_HUMANBioGRID11834832 16799563 details
MED17_HUMANCTDP1_HUMANBioGRID16239144 details
MED17_HUMANBCL6_HUMANBioGRID22668559 details
MED17_HUMANSUZ12_HUMANBioGRID22668559 details
MED17_HUMANHEMGN_HUMANBioGRID24740910 details
MED17_HUMANMED10_HUMANBioGRID, DIP, IntAct10882111 12149480 12584197 14576168 14638676 15175163 15989967 17404243 24882805 24981860 26344197 details
MED17_HUMANCDK19_HUMANBioGRID, IntAct15175163 23602568 23749998 24981860 26186194 28514442 details
MED17_HUMANMED22_HUMANBioGRID, HPRD, IntAct, MINT12584197 24882805 24981860 26344197 details
MED17_HUMANTHA_HUMANBioGRID, IntAct14576168 8710870 details
MED17_HUMANKAT2A_HUMANBioGRID, MINT17967894 18418385 details
MED17_HUMANCDK8_HUMANBioGRID, DIP, IntAct10198638 10882111 11867769 20098423 23602568 23749998 24981860 26186194 26496610 28514442 29568061 details
MED17_HUMANMED6_HUMANBioGRID, IntAct24882805 24981860 26344197 details
MED17_HUMANMED27_HUMANBioGRID, IntAct, MINT24882805 24981860 26344197 details
MED17_HUMANMED12_HUMANBioGRID, IntAct20133760 24981860 26344197 26496610 details
MED17_HUMANMED1_HUMANBioGRID, DIP, IntAct15989967 17967894 18391015 20098423 20133760 24981860 26344197 28514442 details
MED17_HUMANMED8_HUMANBioGRID, HPRD, MINT14576168 24981860 26344197 details
MED17_HUMANMED30_HUMANBioGRID, HPRD, MINT12584197 15989967 24981860 details
MED17_HUMANBRCA1_HUMANBioGRID11504724 12154023 details
MED17_HUMANBARD1_HUMANBioGRID12154023 details
MED17_HUMANBRD4_HUMANBioGRID16109376 32416067 details
MED17_HUMANPARP1_HUMANBioGRID16204234 details
MED17_HUMANTRRAP_HUMANBioGRID18418385 details
MED17_HUMANST65G_HUMANBioGRID17967894 details
MED17_HUMANSUPT3_HUMANBioGRID17967894 details
MED17_HUMANZC3HD_HUMANBioGRID20133760 details
MED17_HUMANTRIP4_HUMANBioGRID20133760 details
MED17_HUMANSTN1_HUMANBioGRID20133760 details
MED17_HUMANQKI_HUMANBioGRID20133760 details
MED17_HUMANMED25_HUMANBioGRID14657022 details
MED17_HUMANMED15_HUMANBioGRID14657022 24981860 26344197 details
MED17_HUMANMED14_HUMANBioGRID22939629 24981860 26344197 9989412 details
MED17_HUMANFBXW7_HUMANBioGRID23322298 25720964 details
MED17_HUMANUBP49_HUMANHPRD14576168 details