Entity Details
| Primary name |
PNPO_HUMAN |
| Entity type |
UniProt |
| Source |
Source Link |
Details
| Accession | Q9NVS9 |
| EntryName | PNPO_HUMAN |
| FullName | Pyridoxine-5'-phosphate oxidase |
| TaxID | 9606 |
| Evidence | evidence at protein level |
| Length | 261 |
| SequenceStatus | complete |
| DateCreated | 2003-09-26 |
| DateModified | 2021-06-02 |
Subcellular Location
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Domains
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| Domain | Name | Category | Type |
| IPR000659 | Pyridoxamine 5'-phosphate oxidase | Family | Family |
| IPR011576 | Pyridoxamine 5'-phosphate oxidase, putative | Domain | Domain |
| IPR012349 | FMN-binding split barrel | Family | Homologous superfamily |
| IPR019576 | Pyridoxine 5'-phosphate oxidase, dimerisation, C-terminal | Domain | Domain |
| IPR019740 | Pyridoxamine 5'-phosphate oxidase, conserved site | Site | Conserved site |
Diseases
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| Disease ID | Source | Name | Description |
| 610090 | OMIM | Pyridoxine-5'-phosphate oxidase deficiency (PNPOD) | The main feature of neonatal epileptic encephalopathy is the onset within hours of birth of a severe seizure disorder that does not respond to anticonvulsant drugs and can be fatal. Seizures can cease with the administration of PLP, being resistant to treatment with pyridoxine,. The disease is caused by variants affecting the gene represented in this entry. |
Drugs
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| Drug | Name | Source | Type |
| DB00114 | Pyridoxal phosphate | Drugbank | small molecule |
| DB02209 | Pyridoxine phosphate | Drugbank | small molecule |
| DB03247 | Flavin mononucleotide | Drugbank | small molecule |
| DB03345 | Mercaptoethanol | Drugbank | small molecule |
Interactions
5 interactions