Entity Details

Primary name THG1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9NWX6
EntryNameTHG1_HUMAN
FullNameProbable tRNA(His) guanylyltransferase
TaxID9606
Evidenceevidence at protein level
Length298
SequenceStatuscomplete
DateCreated2007-05-01
DateModified2021-06-02

Ontological Relatives

GenesTHG1L

GO terms

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GOName
GO:0000049 tRNA binding
GO:0000287 magnesium ion binding
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005524 ATP binding
GO:0005525 GTP binding
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0005829 cytosol
GO:0006400 tRNA modification
GO:0006979 response to oxidative stress
GO:0008033 tRNA processing
GO:0008053 mitochondrial fusion
GO:0008193 tRNA guanylyltransferase activity
GO:0016779 nucleotidyltransferase activity
GO:0042802 identical protein binding
GO:0051289 protein homotetramerization
GO:1990046 stress-induced mitochondrial fusion
GO:1990234 transferase complex

Subcellular Location

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Subcellular Location
Cytoplasm
Mitochondrion outer membrane

Domains

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DomainNameCategoryType
IPR007537 tRNAHis guanylyltransferase Thg1FamilyFamily
IPR024956 tRNAHis guanylyltransferase catalytic domainDomainDomain
IPR025845 Thg1 C-terminal domainDomainDomain
IPR038469 tRNAHis guanylyltransferase Thg1 superfamilyFamilyHomologous superfamily

Diseases

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Interactions

8 interactions