Entity Details

Primary name RIPK2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO43353
EntryNameRIPK2_HUMAN
FullNameReceptor-interacting serine/threonine-protein kinase 2
TaxID9606
Evidenceevidence at protein level
Length540
SequenceStatuscomplete
DateCreated2002-05-02
DateModified2021-06-02

Ontological Relatives

GenesRIPK2

GO terms

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GOName
GO:0000187 obsolete activation of MAPK activity
GO:0001961 positive regulation of cytokine-mediated signaling pathway
GO:0002250 adaptive immune response
GO:0002827 positive regulation of T-helper 1 type immune response
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004706 JUN kinase kinase kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004715 non-membrane spanning protein tyrosine kinase activity
GO:0005102 signaling receptor binding
GO:0005524 ATP binding
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0006915 apoptotic process
GO:0006954 inflammatory response
GO:0007165 signal transduction
GO:0007249 I-kappaB kinase/NF-kappaB signaling
GO:0007254 JNK cascade
GO:0007257 obsolete activation of JUN kinase activity
GO:0010800 positive regulation of peptidyl-threonine phosphorylation
GO:0010942 positive regulation of cell death
GO:0030274 LIM domain binding
GO:0031398 positive regulation of protein ubiquitination
GO:0031663 lipopolysaccharide-mediated signaling pathway
GO:0031982 vesicle
GO:0032092 positive regulation of protein binding
GO:0032722 positive regulation of chemokine production
GO:0032727 positive regulation of interferon-alpha production
GO:0032728 positive regulation of interferon-beta production
GO:0032729 positive regulation of interferon-gamma production
GO:0032731 positive regulation of interleukin-1 beta production
GO:0032735 positive regulation of interleukin-12 production
GO:0032743 positive regulation of interleukin-2 production
GO:0032755 positive regulation of interleukin-6 production
GO:0032760 positive regulation of tumor necrosis factor production
GO:0032991 protein-containing complex
GO:0033091 positive regulation of immature T cell proliferation
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0034134 toll-like receptor 2 signaling pathway
GO:0034142 toll-like receptor 4 signaling pathway
GO:0042098 T cell proliferation
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0043065 positive regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043330 response to exogenous dsRNA
GO:0045087 innate immune response
GO:0045627 positive regulation of T-helper 1 cell differentiation
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046330 positive regulation of JNK cascade
GO:0046641 positive regulation of alpha-beta T cell proliferation
GO:0050700 CARD domain binding
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050830 defense response to Gram-positive bacterium
GO:0050852 T cell receptor signaling pathway
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0070423 nucleotide-binding oligomerization domain containing signaling pathway
GO:0070427 nucleotide-binding oligomerization domain containing 1 signaling pathway
GO:0070431 nucleotide-binding oligomerization domain containing 2 signaling pathway
GO:0070498 interleukin-1-mediated signaling pathway
GO:0070671 response to interleukin-12
GO:0070673 response to interleukin-18
GO:0071223 cellular response to lipoteichoic acid
GO:0071224 cellular response to peptidoglycan
GO:0071225 cellular response to muramyl dipeptide
GO:0089720 caspase binding
GO:0097202 activation of cysteine-type endopeptidase activity
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:1904417 positive regulation of xenophagy

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domainDomainDomain
IPR001315 CARD domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR011029 Death-like domain superfamilyFamilyHomologous superfamily
IPR017322 Receptor-interacting serine/threonine-protein kinase 2FamilyFamily
IPR042149 RIP2, CARD domainDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB12010 FostamatinibDrugbanksmall molecule

Interactions

80 interactions

InteractorPartnerSourcesPublicationsLink
RIPK2_HUMANNOD1_HUMANBioGRID, HPRD, IntAct, MINT, UniProt10224040 10329646 12459189 16517750 17054981 23300079 29997244 details
RIPK2_HUMANNOD2_HUMANBioGRID, HPRD, IntAct, MINT11087742 15620648 19592251 21097508 21123652 21931826 22607974 22829933 26670046 27545878 27812135 details
RIPK2_HUMANRIPK2_HUMANBioGRID, IntAct14743216 21123652 25416956 27045108 32296183 details
RIPK2_HUMANUBC9_HUMANBioGRID, HPRD, IntAct16189514 details
RIPK2_HUMANBIRC2_HUMANBioGRID, HPRD, IntAct19464198 21931591 30026309 9642260 9705938 details
RIPK2_HUMANXIAP_HUMANBioGRID, DIP, IntAct19667203 21931591 22607974 22815893 23818254 25416956 29452636 30026309 31515488 details
RIPK2_HUMANBIRC3_HUMANBioGRID, IntAct19464198 21931591 9705938 details
RIPK2_HUMANMAVS_HUMANBioGRID, IntAct21903422 details
RIPK2_HUMANKDM3A_HUMANBioGRID, MINT23455924 details
RIPK2_HUMANANM2_HUMANBioGRID, MINT23455924 details
RIPK2_HUMANTRAF3_HUMANBioGRID, I2D23333941 details
RIPK2_HUMANLRRK2_HUMANBioGRID20949042 details
RIPK2_HUMANIKKA_HUMANBioGRID22547678 details
RIPK2_HUMANPELI3_HUMANBioGRID23892723 details
RIPK2_HUMANZNRF4_HUMANBioGRID28656966 details
RIPK2_HUMANNEMO_HUMANBioGRID, HPRD, MINT10880512 18079694 details
RIPK2_HUMANTRAF1_HUMANBioGRID, HPRD, MINT9705938 details
RIPK2_HUMANCASP1_HUMANBioGRID, HPRD, MINT9705938 details
RIPK2_HUMANTRAF2_HUMANBioGRID, HPRD, IntAct, MINT21903422 9705938 details
RIPK2_HUMANHS71L_HUMANIntAct14743216 details
RIPK2_HUMANHSP7C_HUMANIntAct14743216 details
RIPK2_HUMANHSP72_HUMANIntAct14743216 details
RIPK2_HUMANHSP76_HUMANIntAct14743216 details
RIPK2_HUMANMYH10_HUMANIntAct14743216 details
RIPK2_HUMANACTG_HUMANIntAct14743216 details
RIPK2_HUMANECHB_HUMANIntAct14743216 details
RIPK2_HUMANGEMI4_HUMANIntAct14743216 details
RIPK2_HUMANTBB2B_HUMANIntAct14743216 details
RIPK2_HUMANCALM2_HUMANIntAct14743216 details
RIPK2_HUMANTBB5_HUMANIntAct14743216 details
RIPK2_HUMANTBB4A_HUMANIntAct14743216 details
RIPK2_HUMANMYH9_HUMANIntAct14743216 details
RIPK2_HUMANENOA_HUMANIntAct14743216 details
RIPK2_HUMANVIME_HUMANBioGRID, IntAct14743216 34079125 details
RIPK2_HUMANHS90A_HUMANIntAct14743216 details
RIPK2_HUMANG3P_HUMANIntAct14743216 details
RIPK2_HUMANTBA3C_HUMANIntAct14743216 details
RIPK2_HUMANTBA3D_HUMANIntAct14743216 details
RIPK2_HUMANMYO1D_HUMANIntAct14743216 details
RIPK2_HUMANATPD_HUMANIntAct17353931 details
RIPK2_HUMANECHM_HUMANIntAct17353931 details
RIPK2_HUMANGXLT1_HUMANIntAct17353931 details
RIPK2_HUMANPIMT_HUMANIntAct17353931 details
RIPK2_HUMANFABP5_HUMANIntAct17353931 details
RIPK2_HUMANKIF14_HUMANIntAct17353931 details
RIPK2_HUMANSODM_HUMANIntAct17353931 details
RIPK2_HUMANRL36_HUMANIntAct17353931 details
RIPK2_HUMANPSB5_HUMANIntAct17353931 details
RIPK2_HUMANPSA7_HUMANIntAct17353931 details
RIPK2_HUMANEZRI_HUMANIntAct17353931 details
RIPK2_HUMANPSA6_HUMANIntAct17353931 details
RIPK2_HUMANROA3_HUMANIntAct17353931 details
RIPK2_HUMANNFAC2_HUMANIntAct17353931 details
RIPK2_HUMANCARD6_HUMANBioGRID, DIP, HPRD12775719 16418290 details
RIPK2_HUMANCFLAR_HUMANBioGRID, HPRD9575181 details
RIPK2_HUMANTRAF5_HUMANBioGRID, HPRD9642260 details
RIPK2_HUMANTRAF6_HUMANBioGRID, HPRD18329614 21097508 9642260 details
RIPK2_HUMANTNR1A_HUMANBioGRID, HPRD9642260 details
RIPK2_HUMANTNR5_HUMANBioGRID, HPRD9642260 details
RIPK2_HUMANM3K7_HUMANBioGRID17348859 17947236 17965022 18079694 details
RIPK2_HUMANTAB1_HUMANBioGRID18079694 details
RIPK2_HUMANTAB2_HUMANBioGRID18079694 details
RIPK2_HUMANNAT16_HUMANBioGRID22607974 details
RIPK2_HUMANRIPK1_HUMANBioGRID22607974 details
RIPK2_HUMANRNF31_HUMANBioGRID22607974 details
RIPK2_HUMANCASPC_HUMANBioGRID18329614 details
RIPK2_HUMANM3K4_HUMANBioGRID21097508 details
RIPK2_HUMANTRAF4_HUMANBioGRID21097508 details
RIPK2_HUMANUBC_HUMANBioGRID23437331 details
RIPK2_HUMANCAR16_HUMANBioGRID, HPRD11432859 11536016 details
RIPK2_HUMANIRF4_HUMANBioGRID24670424 details
RIPK2_HUMANTNR16_HUMANBioGRID, HPRD11487608 16498402 details
RIPK2_HUMANA16L1_HUMANBioGRID32909611 details
RIPK2_HUMANTLR2_HUMANBioGRID, HPRD11894098 32909611 details
RIPK2_HUMANCASP8_HUMANHPRD9575181 details
RIPK2_HUMANSMAD4_HUMANHPRD15761153 details
RIPK2_HUMANSMUF1_HUMANHPRD15761153 details
RIPK2_HUMANIRAK1_HUMANHPRD15691841 details
RIPK2_HUMANTLR4_HUMANHPRD15691841 details
RIPK2_HUMANBCL10_HUMANHPRD14638696 details