Entity Details

Primary name IRPL1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9NZN1
EntryNameIRPL1_HUMAN
FullNameInterleukin-1 receptor accessory protein-like 1
TaxID9606
Evidenceevidence at protein level
Length696
SequenceStatuscomplete
DateCreated2003-08-22
DateModified2021-06-02

Ontological Relatives

GenesIL1RAPL1

GO terms

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GOName
GO:0005102 signaling receptor binding
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
GO:0007165 signal transduction
GO:0009986 cell surface
GO:0010975 regulation of neuron projection development
GO:0016021 integral component of membrane
GO:0030182 neuron differentiation
GO:0030424 axon
GO:0030425 dendrite
GO:0045211 postsynaptic membrane
GO:0045920 negative regulation of exocytosis
GO:0050135 NAD(P)+ nucleosidase activity
GO:0050775 positive regulation of dendrite morphogenesis
GO:0051965 positive regulation of synapse assembly
GO:0061809 NAD+ nucleotidase, cyclic ADP-ribose generating
GO:0071345 cellular response to cytokine stimulus
GO:0097105 presynaptic membrane assembly
GO:0098978 glutamatergic synapse
GO:0099175 regulation of postsynapse organization
GO:0099545 trans-synaptic signaling by trans-synaptic complex
GO:1905606 regulation of presynapse assembly

Subcellular Location

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Subcellular Location
Cell membrane
Cell projection
Cytoplasm

Domains

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DomainNameCategoryType
IPR000157 Toll/interleukin-1 receptor homology (TIR) domainDomainDomain
IPR003598 Immunoglobulin subtype 2DomainDomain
IPR003599 Immunoglobulin subtypeDomainDomain
IPR007110 Immunoglobulin-like domainDomainDomain
IPR013151 ImmunoglobulinDomainDomain
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR015621 Interleukin-1 receptor familyFamilyFamily
IPR035897 Toll/interleukin-1 receptor homology (TIR) domain superfamilyFamilyHomologous superfamily
IPR036179 Immunoglobulin-like domain superfamilyFamilyHomologous superfamily
IPR041416 IL-1Ra-like, immunoglobulin domainDomainDomain

Diseases

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Disease IDSourceNameDescription
300143 OMIMMental retardation, X-linked 21 (MRX21)A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. Intellectual deficiency is the only primary symptom of non-syndromic X-linked mental retardation, while syndromic mental retardation presents with associated physical, neurological and/or psychiatric manifestations. The disease is caused by variants affecting the gene represented in this entry.

Interactions

3 interactions

InteractorPartnerSourcesPublicationsLink
IRPL1_HUMANNCS1_HUMANBioGRID, HPRD12783849 details
IRPL1_HUMANRHG22_HUMANBioGRID21926414 details
IRPL1_HUMANPTPRD_HUMANBioGRID21926414 details