Entity Details

Primary name MBD5_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9P267
EntryNameMBD5_HUMAN
FullNameMethyl-CpG-binding domain protein 5
TaxID9606
Evidenceevidence at protein level
Length1494
SequenceStatuscomplete
DateCreated2004-07-19
DateModified2021-06-02

Ontological Relatives

GenesMBD5

GO terms

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GOName
GO:0003682 chromatin binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005694 chromosome
GO:0007399 nervous system development
GO:0010369 chromocenter
GO:0016579 protein deubiquitination
GO:0030496 midbody
GO:0040014 regulation of multicellular organism growth
GO:0042593 glucose homeostasis
GO:0050795 regulation of behavior
GO:0060399 positive regulation of growth hormone receptor signaling pathway
GO:0070062 extracellular exosome

Subcellular Location

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Subcellular Location
Chromosome
Nucleus

Domains

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DomainNameCategoryType
IPR000313 PWWP domainDomainDomain
IPR001739 Methyl-CpG DNA bindingDomainDomain
IPR016177 DNA-binding domain superfamilyFamilyHomologous superfamily
IPR037385 Methyl-CpG-binding domain protein 5/6FamilyFamily

Diseases

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Disease IDSourceNameDescription
156200 OMIMMental retardation, autosomal dominant 1 (MRD1)A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. The disease is caused by variants affecting the gene represented in this entry.

Interactions

6 interactions