Entity Details
| Primary name |
IKBL1_HUMAN |
| Entity type |
UniProt |
| Source |
Source Link |
Details
| Accession | Q9UBC1 |
| EntryName | IKBL1_HUMAN |
| FullName | NF-kappa-B inhibitor-like protein 1 |
| TaxID | 9606 |
| Evidence | evidence at protein level |
| Length | 381 |
| SequenceStatus | complete |
| DateCreated | 2004-03-01 |
| DateModified | 2021-06-02 |
GO terms
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| GO | Name |
| GO:0005634 | nucleus |
| GO:0005654 | nucleoplasm |
| GO:0005829 | cytosol |
| GO:0007249 | I-kappaB kinase/NF-kappaB signaling |
| GO:0031665 | negative regulation of lipopolysaccharide-mediated signaling pathway |
| GO:0032088 | negative regulation of NF-kappaB transcription factor activity |
| GO:0032720 | negative regulation of tumor necrosis factor production |
| GO:0034122 | negative regulation of toll-like receptor signaling pathway |
| GO:0071222 | cellular response to lipopolysaccharide |
Subcellular Location
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| Subcellular Location |
| Nucleus |
Domains
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| Domain | Name | Category | Type |
| IPR020683 | Ankyrin repeat-containing domain | Domain | Domain |
| IPR036770 | Ankyrin repeat-containing domain superfamily | Family | Homologous superfamily |
| IPR038753 | NF-kappa-B inhibitor-like protein 1 | Family | Family |
Diseases
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| Disease ID | Source | Name | Description |
| 180300 | OMIM | Rheumatoid arthritis (RA) | An inflammatory disease with autoimmune features and a complex genetic component. It primarily affects the joints and is characterized by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. Disease susceptibility is associated with variants affecting the gene represented in this entry. |
Interactions
7 interactions