Entity Details

Primary name CRNN_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9UBG3
EntryNameCRNN_HUMAN
FullNameCornulin
TaxID9606
Evidenceevidence at protein level
Length495
SequenceStatuscomplete
DateCreated2007-10-02
DateModified2021-06-02

Ontological Relatives

GenesCRNN

GO terms

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GOName
GO:0005509 calcium ion binding
GO:0005737 cytoplasm
GO:0009408 response to heat
GO:0010468 regulation of gene expression
GO:0010838 positive regulation of keratinocyte proliferation
GO:0014066 regulation of phosphatidylinositol 3-kinase signaling
GO:0016020 membrane
GO:0046914 transition metal ion binding
GO:0048306 calcium-dependent protein binding
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0070062 extracellular exosome
GO:0071345 cellular response to cytokine stimulus
GO:0098609 cell-cell adhesion
GO:1902808 positive regulation of cell cycle G1/S phase transition

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR002048 EF-hand domainDomainDomain
IPR011992 EF-hand domain pairFamilyHomologous superfamily
IPR013787 S100/CaBP-9k-type, calcium binding, subdomainDomainDomain
IPR018247 EF-Hand 1, calcium-binding siteSiteBinding site
IPR026792 CornulinFamilyFamily
IPR034325 S-100DomainDomain

Diseases

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Disease IDSourceNameDescription
133239 OMIMEsophageal cancer (ESCR)A malignancy of the esophagus. The most common types are esophageal squamous cell carcinoma and adenocarcinoma. Cancer of the esophagus remains a devastating disease because it is usually not detected until it has progressed to an advanced incurable stage. Disease susceptibility is associated with variants affecting the gene represented in this entry.