Entity Details

Primary name P2RX2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9UBL9
EntryNameP2RX2_HUMAN
FullNameP2X purinoceptor 2
TaxID9606
Evidenceevidence at protein level
Length471
SequenceStatuscomplete
DateCreated2001-01-24
DateModified2021-06-02

Ontological Relatives

GenesP2RX2

GO terms

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GOName
GO:0001614 purinergic nucleotide receptor activity
GO:0001666 response to hypoxia
GO:0002931 response to ischemia
GO:0003029 detection of hypoxic conditions in blood by carotid body chemoreceptor signaling
GO:0004931 extracellularly ATP-gated cation channel activity
GO:0005524 ATP binding
GO:0005639 integral component of nuclear inner membrane
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0007274 neuromuscular synaptic transmission
GO:0007528 neuromuscular junction development
GO:0007596 blood coagulation
GO:0007605 sensory perception of sound
GO:0009743 response to carbohydrate
GO:0010524 positive regulation of calcium ion transport into cytosol
GO:0014832 urinary bladder smooth muscle contraction
GO:0015276 ligand-gated ion channel activity
GO:0016324 apical plasma membrane
GO:0030432 peristalsis
GO:0033198 response to ATP
GO:0042802 identical protein binding
GO:0043025 neuronal cell body
GO:0043235 receptor complex
GO:0048266 behavioral response to pain
GO:0048741 skeletal muscle fiber development
GO:0050850 positive regulation of calcium-mediated signaling
GO:0050909 sensory perception of taste
GO:0098794 postsynapse

Subcellular Location

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Subcellular Location
Cell membrane

Domains

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DomainNameCategoryType
IPR001429 P2X purinoreceptorFamilyFamily
IPR003045 P2X2 purinoceptorFamilyFamily
IPR027309 P2X purinoreceptor extracellular domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
608224 OMIMDeafness, autosomal dominant, 41 (DFNA41)A form of non-syndromic deafness characterized by onset of progressive sensorineural hearing loss usually in the second decade. The hearing loss is severe and ultimately affects all frequencies. Exposure to noise exacerbates the hearing loss, particularly at high frequencies. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB01069 PromethazineDrugbanksmall molecule