Entity Details

Primary name CATF_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9UBX1
EntryNameCATF_HUMAN
FullNameCathepsin F
TaxID9606
Evidenceevidence at protein level
Length484
SequenceStatuscomplete
DateCreated2001-01-24
DateModified2021-06-02

Ontological Relatives

GenesCTSF

GO terms

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GOName
GO:0004197 cysteine-type endopeptidase activity
GO:0005615 extracellular space
GO:0005764 lysosome
GO:0006508 proteolysis
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0043202 lysosomal lumen
GO:0051603 proteolysis involved in cellular protein catabolic process
GO:0062023 collagen-containing extracellular matrix
GO:0070062 extracellular exosome
GO:1903561 extracellular vesicle

Subcellular Location

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Subcellular Location
Lysosome

Domains

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DomainNameCategoryType
IPR000169 Cysteine peptidase, cysteine active siteSiteActive site
IPR000668 Peptidase C1A, papain C-terminalDomainDomain
IPR013201 Cathepsin propeptide inhibitor domain (I29)DomainDomain
IPR025660 Cysteine peptidase, histidine active siteSiteActive site
IPR038765 Papain-like cysteine peptidase superfamilyFamilyHomologous superfamily
IPR039417 Papain-like cysteine endopeptidaseDomainDomain

Diseases

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Disease IDSourceNameDescription
615362 OMIMCeroid lipofuscinosis, neuronal, 13 (CLN13)A form of neuronal ceroid lipofuscinosis characterized by adult onset of progressive cognitive decline and motor dysfunction leading to dementia and often early death. Some patients develop seizures. Neuronal ceroid lipofuscinoses are progressive neurodegenerative, lysosomal storage diseases characterized by intracellular accumulation of autofluorescent liposomal material. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB01810 [1-(1-Methyl-4,5-Dioxo-Pent-2-Enylcarbamoyl)-2-Phenyl-Ethyl]-Carbamic Acid Benzyl EsterDrugbanksmall molecule
DB01871 [1-(1-Benzyl-3-Hydroxy-2-Oxo-Propylcarbamoyl)-2-Phenyl-Ethyl]-Carbamic Acid Benzyl EsterDrugbanksmall molecule
DB02243 4-Morpholin-4-Yl-Piperidine-1-Carboxylic Acid [1-(3-Benzenesulfonyl-1-Propyl-Allylcarbamoyl)-2-Phenylethyl]-AmideDrugbanksmall molecule
DB03536 Benzyl N-[(2S)-5-(diaminomethylamino)-1-[[(2S)-4-fluoro-3-oxobutan-2-yl]amino]-1-oxopentan-2-yl]carbamateDrugbanksmall molecule
DB03573 WRR-99Drugbanksmall molecule
DB03691 WRR-112Drugbanksmall molecule
DB07913 HOMOPHENYLALANINYLMETHANEDrugbanksmall molecule
DB08775 Benzoyl-tyrosine-alanine-fluoro-methyl ketoneDrugbanksmall molecule

Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
CATF_HUMANTRI55_HUMANBioGRID31391242 details
CATF_HUMANHG2A_HUMANHPRD10748235 details