Entity Details

Primary name KCNQ3_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO43525
EntryNameKCNQ3_HUMAN
FullNamePotassium voltage-gated channel subfamily KQT member 3
TaxID9606
Evidenceevidence at protein level
Length872
SequenceStatuscomplete
DateCreated1999-07-15
DateModified2021-06-02

Ontological Relatives

GenesKCNQ3

GO terms

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GOName
GO:0005249 voltage-gated potassium channel activity
GO:0005251 delayed rectifier potassium channel activity
GO:0005516 calmodulin binding
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0007268 chemical synaptic transmission
GO:0008076 voltage-gated potassium channel complex
GO:0009986 cell surface
GO:0016021 integral component of membrane
GO:0033268 node of Ranvier
GO:0034765 regulation of ion transmembrane transport
GO:0043194 axon initial segment
GO:0045202 synapse
GO:0060081 membrane hyperpolarization
GO:0071805 potassium ion transmembrane transport

Subcellular Location

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Subcellular Location
Cell membrane

Domains

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DomainNameCategoryType
IPR003937 Potassium channel, voltage dependent, KCNQFamilyFamily
IPR003948 Potassium channel, voltage dependent, KCNQ3FamilyFamily
IPR005821 Ion transport domainDomainDomain
IPR013821 Potassium channel, voltage dependent, KCNQ, C-terminalDomainDomain
IPR020969 Ankyrin-G binding siteSiteBinding site
IPR028325 Voltage-gated potassium channelFamilyFamily

Diseases

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Disease IDSourceNameDescription
121201 OMIMSeizures, benign familial neonatal 2 (BFNS2)A disorder characterized by clusters of seizures occurring in the first days of life. Most patients have spontaneous remission by 12 months of age and show normal psychomotor development. The disorder is distinguished from benign familial infantile seizures by an earlier age at onset. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB00228 EnfluraneDrugbanksmall molecule
DB00321 AmitriptylineDrugbanksmall molecule
DB00586 DiclofenacDrugbanksmall molecule
DB00939 Meclofenamic acidDrugbanksmall molecule
DB00996 GabapentinDrugbanksmall molecule
DB01069 PromethazineDrugbanksmall molecule
DB01110 MiconazoleDrugbanksmall molecule
DB04953 EzogabineDrugbanksmall molecule
DB06089 ICA-105665Drugbanksmall molecule