Entity Details

Primary name SEC63_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9UGP8
EntryNameSEC63_HUMAN
FullNameTranslocation protein SEC63 homolog
TaxID9606
Evidenceevidence at protein level
Length760
SequenceStatuscomplete
DateCreated2001-10-18
DateModified2021-06-02

Ontological Relatives

GenesSEC63

GO terms

Show/Hide Table
GOName
GO:0001889 liver development
GO:0003723 RNA binding
GO:0005783 endoplasmic reticulum
GO:0006612 protein targeting to membrane
GO:0006614 SRP-dependent cotranslational protein targeting to membrane
GO:0006620 posttranslational protein targeting to endoplasmic reticulum membrane
GO:0006807 nitrogen compound metabolic process
GO:0008320 protein transmembrane transporter activity
GO:0010259 multicellular organism aging
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0031204 posttranslational protein targeting to membrane, translocation
GO:0031207 Sec62/Sec63 complex
GO:0038023 signaling receptor activity

Subcellular Location

Show/Hide Table
Subcellular Location
Endoplasmic reticulum membrane

Domains

Show/Hide Table
DomainNameCategoryType
IPR001623 DnaJ domainDomainDomain
IPR004179 Sec63 domainDomainDomain
IPR014756 Immunoglobulin E-setFamilyHomologous superfamily
IPR027137 Translocation protein Sec63FamilyFamily
IPR035892 C2 domain superfamilyFamilyHomologous superfamily
IPR036869 Chaperone J-domain superfamilyFamilyHomologous superfamily

Diseases

Show/Hide Table
Disease IDSourceNameDescription
617004 OMIMPolycystic liver disease 2 with or without kidney cysts (PCLD2)An autosomal dominant hepatobiliary disease characterized by overgrowth of biliary epithelium and supportive connective tissue, resulting in multiple liver cysts. A subset of patients may develop kidney cysts that usually do not result in clinically significant renal disease. The disease is caused by variants affecting the gene represented in this entry.